Email this article Clinical and functional changes in patients with bronchial asthma using various nicotine and tobacco intakes
- Authors: Peredelskaya M.1, Nenasheva N.M.2, Yudin A.A.3,4, Burtsev A.N.5, Sebekina O.V.6, Belik O.А.6, Puturidi A.K.7
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Affiliations:
- The Founder of the Academy is the Russian Federation. The powers of the founder are exercised by the Ministry of Healthcare of the Russian Federation.
- Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuous Professional Education”, Ministry of Health of Russia
- The Russian National Research Medical University named after N.I. Pirogov
- City Clinical Hospital N 24
- SberBank Data Processing Specialist, Sberbank Model Risk Department, Center for Model Risks of Retail Business
- The Federal State Budgetary Educational Institution of Further Professional Education "Russian Medical Academy of Continuous Professional Education" of the Ministry of Healthcare of the Russian
- City Clinical Hospital No24
- Section: Original Research Articles
- Submitted: 15.12.2025
- Accepted: 12.02.2026
- Published: 12.02.2026
- URL: https://medjrf.com/0869-2106/article/view/698545
- DOI: https://doi.org/10.17816/medjrf698545
- ID: 698545
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Abstract
BACKGROUND: This study aims to address this knowledge gap through comprehensive assessment of clinical and functional changes in asthma patients using various nicotine consumption methods.
AIM: To evaluate the impact of different types of smoking devices (conventional cigarettes, ENDS, HTPs) on asthma course and control, lung function, quality of life, and inflammatory profile in patients aged 18–45 years.
METHODS: An open observational study was conducted at Moscow City Clinical Hospital No. 24. Inclusion criteria: age 18–45 years, asthma diagnosis duration ≥12 months. Exclusion criteria: acute respiratory viral infection, pregnancy, chronic obstructive pulmonary disease, other lung diseases. Primary endpoints: asthma control (ACT questionnaire), quality of life (AQLQ questionnaire), forced expiratory volume in 1 second (FEV₁), inflammatory biomarkers (blood eosinophils, eosinophil cationic protein (ECP), periostin, thymic stromal lymphopoietin (TSLP), interleukin-13 (IL-13)). Assessment methods included validated questionnaires, spirometry, fractional exhaled nitric oxide (FeNO) measurement, and laboratory blood analysis.
RESULTS: The study included 153 patients (149 men, 4 women), mean age 22.14±3.09 years. Among them, 59 were non-smokers and 94 were smokers, with 56.4% of smokers being multi-users of various smoking devices. Smoking patients had worse asthma control by 2.7 points on the ACT scale (p<0.001), FEV₁ lower by 4.5% (p<0.05), and quality of life by AQLQ questionnaire lower by 0.83 points (p<0.001) compared to non-smokers. A change in inflammatory phenotype was identified: ECP level was 18.3% lower (p<0.05), blood eosinophils 10.3% lower, neutrophil level 14.3% higher (p<0.01) in smokers. Elevated levels of periostin by 31.0% (p<0.05) and TSLP by 73.5% (p<0.05) were observed in smoking patients. Subgroup analysis by smoking device type (conventional cigarettes, ENDS, HTPs, their combinations) revealed no statistically significant differences (p>0.05).
CONCLUSION: All types of smoking devices have comparable negative effects on asthma control, lung function, and patients' quality of life, and lead to changes in inflammatory phenotype with reduced eosinophilic and enhanced neutrophilic components.
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About the authors
Marina Peredelskaya
The Founder of the Academy is the Russian Federation. The powers of the founder are exercised by the Ministry of Healthcare of the Russian Federation.
Author for correspondence.
Email: concy1984@gmail.com
ORCID iD: 0000-0003-2682-8108
SPIN-code: 3336-5507
Candidate of Medical Sciences, Associate Professor of the Department of Allergy and Immunology
Russian FederationNatalya M. Nenasheva
Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuous Professional Education”, Ministry of Health of Russia
Email: 1444031@gmail.com
ORCID iD: 0000-0002-3162-2510
SPIN-code: 3363-6170
Doctor of Medical Sciences, Professor, Head of the Department of Allergology and Immunology
Russian Federation, st. Barrikadnaya, 2/1, build. 1, Moscow, 125993Alexander A. Yudin
The Russian National Research Medical University named after N.I. Pirogov; City Clinical Hospital N 24
Email: youdine@gmail.com
ORCID iD: 0000-0003-3419-8521
SPIN-code: 8955-0169
MD, Cand. Sci. (Med.), Associate Professor
Russian Federation, Moscow; MoscowArtem N. Burtsev
SberBank Data Processing Specialist, Sberbank Model Risk Department, Center for Model Risks of Retail Business
Email: prometneus@gmail.com
ORCID iD: 0009-0004-8588-063X
Russian Federation, Moscow Vavilova 19
Oksana V. Sebekina
The Federal State Budgetary Educational Institution of Further Professional Education "Russian Medical Academy of Continuous Professional Education" of the Ministry of Healthcare of the Russian
Email: Sebekin1@mail.ru
ORCID iD: 0000-0002-3508-9602
SPIN-code: 2922-9398
кандидат медицинских наук
доцент
Russian Federation, Moscow Barricadnaya 2|1Olga А. Belik
The Federal State Budgetary Educational Institution of Further Professional Education "Russian Medical Academy of Continuous Professional Education" of the Ministry of Healthcare of the Russian
Email: olgabelik13@gmail.com
ORCID iD: 0009-0002-1865-5024
SPIN-code: 6790-9032
врач ординатор
Russian Federation, Moscow Barricadnaya 2\1Anna Kh Puturidi
City Clinical Hospital No24
Email: puturava@bk.ru
ORCID iD: 0009-0007-5532-3033
врач аллерголог
Russian Federation, Russia, Moscow, Piscovaya St., 10References
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