Russian MedicineRussian MedicineРоссийский медицинский журнал0869-21062412-9100Eco-Vector10889610.17816/0869-2106-2021-27-6-589-600ReviewsНаучные обзорыReview ArticleGhrelin as a promising biological marker in cardiovascular diseaseГрелин — перспективный биологический маркер при сердечно-сосудистых заболеванияхhttps://orcid.org/0000-0001-5416-85792749-6427AlievaAmina M.АлиеваАмина Магомедовна
Russian Federation

MD, Cand. Sci. (Med.), assistant professor

к.м.н., доцент

amisha_alieva@mail.ruhttps://orcid.org/0000-0002-7877-4407PinchukTatyana V.ПинчукТатьяна Витальевна
Russian Federation

MD, Cand. Sci. (Med.), assistant professor

к.м.н., доцент

doktor2000@inbox.ruhttps://orcid.org/0000-0003-0886-62903054-8884BaikovaIrina E.БайковаИрина Евгеньевна
Russian Federation

MD, Cand. Sci. (Med.), assistant professor

к.м.н., доцент

1498553@mail.ruhttps://orcid.org/0000-0003-3000-0987ShnakhovaLidia M.ШнаховаЛидия Мухамедовна
Russian Federation
Shnakhova_I_m@staff.sechenov.ruhttps://orcid.org/0000-0003-1111-63781636-7627VoronkovaKira V.ВоронковаКира Владимировна
Russian Federation

MD, Dr. Sci. (Med.), professor

д.м.н., профессор

kiravoronkova@yandex.ruhttps://orcid.org/0000-0003-1613-37162855-2867ValievRamiz K.ВалиевРамиз Камраддинович
Russian Federation

MD, Cand. Sci. (Med.)

к.м.н.

Radiosurgery@bk.ruhttps://orcid.org/0000-0001-9601-1174RakhaevAlik M.РахаевАлик Магомедович
Russian Federation

MD, Dr. Sci. (Med.), professor

д.м.н., профессор

alikrahaev@yandex.ruArakelyanRoza A.АракелянРоза Арамовна
Russian Federation
Elmira.sharm@yandex.ruhttps://orcid.org/0000-0002-8949-4523KalovaMarina R.КаловаМарина Ризуановна
Russian Federation
marina717717@mail.ruhttps://orcid.org/0000-0003-1699-0881NikitinIgor G.НикитинИгорь Геннадиевич
Russian Federation

MD, Dr. Sci. (Med.), professor

д.м.н., профессор

igor.nikitin.64@mail.ruPirogov Russian National Research Medical UniversityРоссийский национальный исследовательский медицинский университет им. Н.И. ПироговаI.M. Sechenov First Moscow State Medical UniversityПервый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)A.S. Loginov Moscow Clinical Scientific and Practical CenterМосковский клинический научно-практический центр им. А.С. ЛогиноваKh.M. Berbekov Kabardino-Balkarian State UniversityКабардино-Балкарский государственный университет им. Х.М. Бербекова190720222765896002106202222062022Copyright ©; 2022, Alieva A.M., Pinchuk T.V., Baikova I.E., Shnakhova L.M., Voronkova K.V., Valiev R.K., Rakhaev A.M., Arakelyan R.A., Kalova M.R., Nikitin I.G.Copyright ©; 2022, Алиева А.М., Пинчук Т.В., Байкова И.Е., Шнахова Л.М., Воронкова К.В., Валиев Р.К., Рахаев А.М., Аракелян Р.А., Калова М.Р., Никитин И.Г.2022Alieva A.M., Pinchuk T.V., Baikova I.E., Shnakhova L.M., Voronkova K.V., Valiev R.K., Rakhaev A.M., Arakelyan R.A., Kalova M.R., Nikitin I.G.Алиева А.М., Пинчук Т.В., Байкова И.Е., Шнахова Л.М., Воронкова К.В., Валиев Р.К., Рахаев А.М., Аракелян Р.А., Калова М.Р., Никитин И.Г.https://creativecommons.org/licenses/by-nc-nd/4.0/https://medjrf.com/0869-2106/article/view/108896

This review highlights the current literature data on the peptide hormone ghrelin. Ghrelin is a 28-amino-acid peptide, which is the only known peptide hormone modified with fatty acids. Ghrelin is a natural receptor ligand that stimulates the secretion of growth hormones. In addition to the stomach, ghrelin is expressed in many organs such as the duodenum, jejunum, ileum, colon, lungs, heart, pancreas, kidneys, testicles, pituitary gland, and hypothalamus. The main biological functions of this peptide include growth hormone secretion, appetite stimulation, modulation of gastric acid secretion and motility, and an increase in endocrine and exocrine pancreatic secretions. Reference intervals for ghrelin are 8.502–16.6 pg/mL. The studies analyzed have shown a strong relationship between ghrelin and cardiovascular system function. Studies have also described the cardioprotective effects of ghrelin. However, the molecular mechanisms underlying the effects of ghrelin on the heart are not fully understood. A further deeper understanding of the role of ghrelin and future clinical studies are necessary to determine the diagnostic, prognostic, and possibly therapeutic significance of this biomarker.

В представленном обзоре освещены современные литературные данные о пептидном гормоне грелине. Грелин — это пептид, состоящий из 28 аминокислот, единственный известный пептидный гормон, модифицированный жирными кислотами. Грелин является естественным лигандом рецептора, стимулирующего секрецию гормона роста. Помимо желудка, грелин экспрессируется во многих органах, таких как двенадцатиперстная кишка, тощая кишка, подвздошная кишка, толстая кишка, легкие, сердце, поджелудочная железа, почки, яички, гипофиз и гипоталамус. Основные биологические функции данного пептида включают секрецию гормона роста, стимуляцию аппетита, модуляцию секреции и моторики желудочного сока, а также повышение эндокринной и экзокринной секреций поджелудочной железы. Референсные интервалы грелина составляют 8,502–16,6 пг/мл. Проанализированные исследования показали сильную связь между грелином и сердечно-сосудистой системой. Также опубликованы данные, описывающие кардиопротекторные эффекты грелина. Однако молекулярные механизмы, лежащие в основе воздействия грелина на сердце, до конца не ясны. Необходимо дальнейшее более глубинное понимание роли грелина, а также будущие клинические исследования для определения диагностической, прогностической и возможно терапевтической значимости данного биомаркера.

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