Russian MedicineRussian MedicineРоссийский медицинский журнал0869-21062412-9100Eco-Vector10889710.17816/0869-2106-2021-27-6-561-569Clinical medicineКлиническая медицинаResearch ArticleBlood serum concentration of troponin in patients with COVID-19 of various severitiesКонцентрация тропонина в сыворотке крови у больных с COVID-19 различной тяжестиhttps://orcid.org/0000-0002-9176-1889KovtyukhIrina V.КовтюхИрина Владимировна
Russian Federation
ivkovtuh@mail.ruhttps://orcid.org/0000-0002-7846-1611GendlinGennady E.ГендлинГеннадий Ефимович
Russian Federation

MD, Dr. Sci.(Med.), Professor

д.м.н., профессор

rgmugt2@mail.ruhttps://orcid.org/0000-0003-1699-0881NikitinIgor G.НикитинИгорь Геннадьевич
Russian Federation

MD, Dr. Sci.(Med.), Professor

д.м.н., профессор

igor.nikitin.64@mail.ruhttps://orcid.org/0000-0001-5414-0250NikitinAleksey E.НикитинАлексей Эдуардович
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

glavvrach@ckb.ruhttps://orcid.org/0000-0003-4891-9959AleshenkoNatalya L.АлешенкоНаталья Леонидовна
Russian Federation
nl.aleshenko@gmail.comhttps://orcid.org/0000-0002-7356-7273RoginkoOlga A.РогинкоОльга Анатольевна
Russian Federation
3115028@mail.ruPetrovsky National Research Centre of SurgeryРоссийский научный центр хирургии имени академика Б.В. ПетровскогоN.I. Pirogov Russian National Research Medical UniversityРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова190720222765615692106202222062022Copyright ©; 2022, Kovtyukh I.V., Gendlin G.E., Nikitin I.G., Nikitin A.E., Aleshenko N.L., Roginko O.A.Copyright ©; 2022, Ковтюх И.В., Гендлин Г.Е., Никитин И.Г., Никитин А.Э., Алешенко Н.Л., Рогинко О.А.2022Kovtyukh I.V., Gendlin G.E., Nikitin I.G., Nikitin A.E., Aleshenko N.L., Roginko O.A.Ковтюх И.В., Гендлин Г.Е., Никитин И.Г., Никитин А.Э., Алешенко Н.Л., Рогинко О.А.https://creativecommons.org/licenses/by-nc-nd/4.0/https://medjrf.com/0869-2106/article/view/108897

BACKGROUND: The search for available predictors of hospital survival and mortality rates during the COVID-19 pandemic is an urgent problem.

AIM: The study aimed to determine the role of troponin in the immediate prognosis of patients with COVID-19.

MATERIALS AND METHODS: The study included 85 patients with a new coronavirus infection upon admission, who underwent a blood test for troponin. All patients underwent an echocardiographic study according to a standard protocol, and the effect of troponin levels on nosocomial survival and mortality rates, correlation of this indicator with the left ventricular ejection fraction, degree of pulmonary hypertension, laboratory parameters, and degree of respiratory failure determined by computed tomography of the lungs and oxygen saturation indicators were analyzed. Correlation analysis with autopsy parameters was performed.

RESULTS: A high level of troponin indicated the worst prognosis of patients during hospitalization. The laboratory marker level correlated significantly with the parameters of the left ventricular ejection fraction. Its highest level was determined in patients with type 1 myocardial infarction. Troponin was not correlated with the degree of respiratory failure, as well as the state of the myocardium in the autopsy material.

CONCLUSIONS: Determining the troponin levels as a routine laboratory marker can be recommended for stratifying the risk of myocardial damage in patients with COVID-19 during hospitalization.

Обоснование. Поиск доступных предикторов госпитальной выживаемости и летальности пациентов с COVID-19 является актуальной проблемой в условиях пандемии.

Цель. Определить роль тропонина в ближайшем прогнозе пациентов с COVID-19.

Материалы и методы. В исследовании включены 85 пациентов с новой коронавирусной инфекцией на момент госпитализации их в стационар, которым проведен анализ крови на тропонин. Всем пациентам проведено эхокардиографическое исследование по стандартному протоколу, анализ влияния уровня тропонина на госпитальную выживаемость и летальность, корреляция данного показателя с фракцией выброса левого желудочка, степенью легочной гипертензии, лабораторными показателями, степенью дыхательной недостаточности, определяемой по данным компьютерной томографии легких и показателями сатурации кислорода. Выполнена корреляция с показателями аутопсии.

Результаты. Высокий уровень тропонина определял наихудший прогноз пациентов в госпитальном периоде. Уровень лабораторного маркера достоверно коррелировал с показателями фракции выброса левого желудочка. Наиболее высокий его уровень определялся у пациентов с инфарктом миокарда 1 типа. Корреляции тропонина со степенью дыхательной недостаточности, а также состоянием миокарда при аутопсийном материале выявлено не было.

Заключение. Определение уровня тропонина как рутинного лабораторного маркера можно рекомендовать для стратификации риска повреждения миокарда пациентам с COVID-19 на госпитальном этапе.

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