Russian MedicineRussian Medicine0869-21062412-9100Eco-Vector3787610.17816/rmj37876Postmortem liver morphological characteristics in patients with chronic viral hepatitides with clinical signs of cirrhosisNovakK E-KarevV E-DunaevaNatal'ya Viktorovnanvch@mail.ruEsaulenkoE V-NovakK E-KarevV E-DunayevaN V-EsaulenkoE V-1504201117281121072020Copyright © 2011, Eco-Vector2011Autopsy protocols and the microscope slides of liver tissue were analyzed to compare its postmortem morphological characteristics in 94 patients with different nosological entities of chronic viral hepatitis with clinical signs of cirrhosis. According to the nosology of hepatitis, the patients were divided into 3 groups: 1) 38 patients with hepatitis B; 2) 32 patients with hepatitis C; 3) 24 patients with mixed hepatitis B + C. The patients with hepatitis B and C alone in the cirrhotic transformation stage were shown to have similar morphological changes in liver tissue at the moment of death. Patients with cirrhosis of mixed viral etiology die at a younger age and differ from those with mono virus cirrhosis in the higher incidence of circulatory disorders and their considerable degree. According to morphological findings, no completed cirrhotic liver transformation was observed in some patients with clinical signs of cirrhosis.chronic viral hepatitideshepatic cirrhosismorphologyхронические вирусные гепатитыцирроз печениморфология[Комарова Д. В., Цинзерлинг В. А. Морфологическая диагностика инфекционных поражений печени. - СПб., 1999.][Лобзин Ю. В., Жданов К. В., Волжанин В. М. Вирусные гепатиты. - СПб., 1999.][Непомнящих Д. Л., Айдагулова С. В., Непомнящих Г. И. Биопсия печени: патоморфогенез хронического гепатита и цирроза. - М., 2006.][Эсауленко Е. В. Клинико-морфологические аспекты хронических вирусных гепатитов: Автореф. дис. ... д-ра мед. наук. - СПб., 1998.][Acalovschi M., Buzas C., Radu C., Grigorescu M. // J. Viral Hepatit. - 2009. - Vol. 16, N 12. - P. 860-866.][Boccato S., Pistis R., Noventa F. et al. // J. Viral Hepatit. - 2006. - Vol. 13, N 5. - P. 297-302.][Cadranel J.-F., Lahmek P., Causse X. et al. // Aliment. Pharmacol. Ther. - 2007. - Vol. 26, N 4. - P. 565-576.][Cross T. J. S., Quaglia A., Hughes S. et al. // J. Viral Hepatit. - 2009. - Vol. 16, N 7. - P. 492-499.][Czaja A. J., Carpenter H. A. // Gastroenterology. - 1993. - Vol. 105, N 6. - P. 1824-1832.][Desmet V. J., Gerber M., Hoofnagle J. H. et al. // Hepatology. - 1994. - Vol. 19, N 6. - P. 1513-1520.][Fattovich G., Stroffolini T., Zagni I., Donato F. // Gastroenterology. - 2004. - Vol. 127, N 5, suppl. 1. - P. S35-S50.][Ghany M. G., Kleiner D. E., Alter H. et al. // Gastroenterology. - 2003. - Vol. 124, N 1. - P. 97-104.][Ginés P., Quintero E., Arroyo V. et al. // Hepatology. - 1987. - Vol. 7, N 1. - P. 122-128.][Knodell R. G., Ishak K. G., Black W. C. et al. // Hepatology. - 1981. - Vol. 1, N 5. - P. 431-435.][Marcellin P. // Liver Int. - 2009. - Vol. 29, N 1. - P. 1-8.][Mathurin P., Thibault V., Kadidja K. et al. // J. Viral Hepatit. - 2000. - Vol. 7. - P. 15-22.][Matos C., Perez R., Pacheco M. S. et al. // J. Gastroenterol. Hepatol. - 2006. - Vol. 21, N 8. - P. 1236-1239.][Park B. K., Park Y. N., Ahn S. H. et al. // J. Gastroenterol. Hepatol. - 2007. - Vol. 22, N 3. - P. 383-388.][Peng D., Han Y., Ding H., Wei L. // J. Gastroenterol. Hepatol. - 2008. - Vol. 23, N 7. - P. 1082-1088.][Poynard T., Ratziu V., Benmanov Y. et al. // Semin. Liver Dis. - 2000. - Vol. 20, N 1. - P. 47-55.][Shi J. P., Fan J. G., Wu R. et al. // Zhonghua Gan Zang Bing Za Zhi. - 2008. - Vol. 16, N 7. - P. 519-523.][Tsochatzis E., Papatheodoridis G. V., Manesis E. K. et al. // Dig. Liver Dis. - 2007. - Vol. 39, N 10. - P. 936-942.][Weissberg J. I., Andres L. L., Smith C. I. et al. // Ann. Intern. Med. - 1984. - Vol. 101. - P. 613-616.][Wolf D. Cirrhosis. http://emedicine.medscape.com/article/ 366426-overview (состояние на 03.05.10).][Zarski J. P., Bohn B., Bastie A. et al. // J. Hepatol. - 1998. - Vol. 28, N 1. - P. 27-33.]