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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Russian Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-2106</issn><issn publication-format="electronic">2412-9100</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">38247</article-id><article-id pub-id-type="doi">10.17816/rmj38247</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The prevention of development of syndrome of hyperstimulation of ovary in program of extra-corporeal fertilization</article-title><trans-title-group xml:lang="ru"><trans-title>Предупреждение развития синдрома гиперстимуляции яичников в программе экстракорпорального оплодотворения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Scherbakova</surname><given-names>Liya N.</given-names></name><name xml:lang="ru"><surname>Щербакова</surname><given-names>Лия Ниязовна</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, PhD, assistant professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, ассистент кафедры акушерства и гинекологии факультета фундаментальной медицины</p></bio><email>liya@post.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ivanova</surname><given-names>N. V</given-names></name><name xml:lang="ru"><surname>Иванова</surname><given-names>Н. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bugerenko</surname><given-names>A. E</given-names></name><name xml:lang="ru"><surname>Бугеренко</surname><given-names>А. Е</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Panina</surname><given-names>O. B</given-names></name><name xml:lang="ru"><surname>Панина</surname><given-names>О. Б</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">The M.V. Lomonosov Moscow state university</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВПО "Московский государственный университет им. М.В. Ломоносова"</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2015</year></pub-date><volume>21</volume><issue>1</issue><issue-title xml:lang="en">VOL 21, NO1 (2015)</issue-title><issue-title xml:lang="ru">ТОМ 21, №1 (2015)</issue-title><fpage>28</fpage><lpage>31</lpage><history><date date-type="received" iso-8601-date="2020-07-21"><day>21</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО "Эко-Вектор"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://medjrf.com/0869-2106/article/view/38247">https://medjrf.com/0869-2106/article/view/38247</self-uri><abstract xml:lang="en"><p>The article presents results of comparative analysis of procedure of extra-corporeal fertilization in female patients with early (before embryo transfer) and late (after embryo transfer) syndrome of hyper-stimulation of ovary. The common risk factors for early and late syndrome of extra-corporeal fertilization (age less than 32 years, body mass index less than 24.5 kg/m2, syndrome of poly-cystic ovary) and specific risk factors for early form (male sterility, application of agonists of gonadotropin -releasing hormone) and late form (onset of multiple pregnancy) of syndrome of extra-corporeal fertilization are established. The techniques of prevention of early and late syndrome of extra-corporeal fertilization are presented.</p></abstract><trans-abstract xml:lang="ru"><p>Проведен сравнительный анализ процедуры экстракорпорального оплодотворения (ЭКО) у пациенток с ранним (до переноса эмбриона) и поздним (после переноса эмбриона) синдромом гиперстимуляции яичников (СГЯ). Определены общие факторы риска для раннего и позднего СГЯ (возраст &lt; 32 лет, индекс массы тела (ИМТ) &lt; 24,5 кг/м 2, синдром поликистозных яичников (СПКЯ)) и специфические факторы риска для ранней формы (мужское бесплодие, использование агонистов ГнРГ) и поздней формы СГЯ (наступление многоплодной беременности). Приведены методы профилактики раннего и позднего СГЯ.</p></trans-abstract><kwd-group xml:lang="en"><kwd>syndrome of extra-corporeal fertilization</kwd><kwd>risk factor</kwd><kwd>agonists of gonadotropin-releasing hormone</kwd><kwd>prevention</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>синдром гиперстимуляции яичников</kwd><kwd>факторы риска</kwd><kwd>агонисты гонадотропин-рилизинг-гормона</kwd><kwd>профилактика</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Линде В.А., Добровольский М.С., Иванов А.В. Синдром гиперстимуляции яичников. 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