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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Russian Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-2106</issn><issn publication-format="electronic">2412-9100</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">38262</article-id><article-id pub-id-type="doi">10.17816/rmj38262</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The outcomes of pregnancy and delivery in women with mechanical prostheses of cardiac valves</article-title><trans-title-group xml:lang="ru"><trans-title>Исходы беременности и родов у женщин с механическими протезами клапанов сердца</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Adilova</surname><given-names>Leyla R.</given-names></name><name xml:lang="ru"><surname>Адилова</surname><given-names>Лейла Рауфовна</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры репродуктивной медицины и хирургии</p></bio><email>adilova-leila@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Adamian</surname><given-names>L. V</given-names></name><name xml:lang="ru"><surname>Адамян</surname><given-names>Л. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Liashko</surname><given-names>E. S</given-names></name><name xml:lang="ru"><surname>Ляшко</surname><given-names>Е. С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shifman</surname><given-names>E. M</given-names></name><name xml:lang="ru"><surname>Шифман</surname><given-names>Е. М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tulkina</surname><given-names>E. E</given-names></name><name xml:lang="ru"><surname>Тюлькина</surname><given-names>Е. Е</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Konisheva</surname><given-names>O. V</given-names></name><name xml:lang="ru"><surname>Конышева</surname><given-names>О. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">The A.E. Evdokimov Moscow state medical stomatological university</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО МГМСУ им. А.И. Евдокимова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">The M.F. Vladimirskii Moscow oblast research clinical institute</institution></aff><aff><institution xml:lang="ru">ГБУЗ МО МОНИКИ им. М.Ф. Владимирского</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">The peoples' friendship university of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВПО "Российский Университет Дружбы Народов"</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">The O.M. Filatov municipal clinical hospital № 15</institution></aff><aff><institution xml:lang="ru">ГБУЗ ГКБ № 15 им. О.М. Филатова</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2015</year></pub-date><volume>21</volume><issue>3</issue><issue-title xml:lang="en">VOL 21, NO3 (2015)</issue-title><issue-title xml:lang="ru">ТОМ 21, №3 (2015)</issue-title><fpage>30</fpage><lpage>35</lpage><history><date date-type="received" iso-8601-date="2020-07-21"><day>21</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО "Эко-Вектор"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://medjrf.com/0869-2106/article/view/38262">https://medjrf.com/0869-2106/article/view/38262</self-uri><abstract xml:lang="en"><p>The study was carried out to examine course of pregnancy and cardiologic, obstetrician and neonatal complications in women with mechanical prosthesises of cardiac valves. The prospective study included 16 pregnant women with mechanical prosthesises of cardiac valves. In the first trimester, the thrombosis of prosthesis valve was discovered in 2 pregnant women. The dysfunction of valve prosthesis in the form of thrombosis of prosthesis was discovered in 2 pregnant women in postnatal period. The para-prosthesis fistula was detected in2 pregnant women. The pregnancy proceeded with menace of miscarriage in 9 women out of 16. In one of these women pregnancy ended by premature delivery. In the rest of examined women pregnancy yielded to conservative therapy. The syndrome of growth inhibition was detected in 7 fetuses. The disorder of hemodynamics in fetoplacental system was established in 4 fetuses. The premature aging of placenta was diagnosed in 3 fetuses. The oligohydramnios was discovered in 8 fetuses and hydramnion was diagnosed in one fetus. The birth of alive children occurred in 16 out of 14 pregnancies. The antenatal fetal death occurred in 2 pregnancies. Among children born alive, 11 children were born at full-term period and three were born prematurely at 32, 35 and 36 weeks of gestation. The body mass-body height indicator of full-term children consisted from 44 to 63. In healthy condition 7 newborns were discharged out of hospital with mothers. In specialized children hospitals 7 newborns were transfered because of health condition. The course of pregnancy in women with mechanical prostheses of cardiac valves is related to high risk of complications of fetus and newborn.</p></abstract><trans-abstract xml:lang="ru"><p>Цель исследования - изучить течение беременности, кардиологические, акушерские и неонатологические осложнения у женщин с механическими протезами клапанов сердца. Материалы и методы: в проспективное исследование включены 16 беременных женщин с механическими протезами клапанов сердца. Результаты: у 2 беременных в I триместре был выявлен тромбоз протезированного клапана, у 2 пациенток выявлена дисфункция протеза клапана в виде тромбоза протеза в послеродовом периоде, еще у 2 беременных выявлена парапротезная фистула. В нашем исследовании у 9 женщин из 16 беременность протекала с угрозой прерывания, у 1 из них беременность завершилась преждевременными родами, у остальных поддалась консервативной терапии. Синдром задержки роста плода I-II степени выявлен у 7 плодов, нарушение гемодинамики в фетоплацентарной системе - у 4 плодов, преждевременное старение плаценты - у 3, маловодие обнаружено у 8 плодов, многоводие - у 1. Из 16 беременностей 14 завершились рождением живых детей, 2- антенатальной гибелью плода. Среди живорожденных 11 детей родились на доношенном сроке, 3 - преждевременно на 32, 35 и 36 нед гестации. Массоростовой показатель доношенных детей составил от 44 до 63. В удовлетворительном состоянии вместе с матерью выписаны домой 7 новорожденных, по состоянию здоровья в специализированные детские больницы переведены 7 новорожденных. Заключение: течение беременности у женщин с механическими протезами клапанов сердца связано с высоким риском осложнений со стороны сердечно-сосудистой системы матери, осложнениями со стороны плода и новорожденного.</p></trans-abstract><kwd-group xml:lang="en"><kwd>mechanical prostheses of cardiac valves</kwd><kwd>pregnancy</kwd><kwd>valve thrombosis</kwd><kwd>para-prosthesis fistula</kwd><kwd>anticoagulant therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>механические протезы клапанов сердца</kwd><kwd>беременность</kwd><kwd>тромбоз клапана</kwd><kwd>парапротезная фистула</kwd><kwd>антикоагулянтная терапия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Vause S., Clarke B. Heart disease in pregnancy. Br. J. Hosp. Med. 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