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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Russian Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-2106</issn><issn publication-format="electronic">2412-9100</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">38300</article-id><article-id pub-id-type="doi">10.17816/rmj38300</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The restless legs' syndrome</article-title><trans-title-group xml:lang="ru"><trans-title>Синдром беспокойных ног</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kopishinskaya</surname><given-names>Svetlana V.</given-names></name><name xml:lang="ru"><surname>Копишинская</surname><given-names>Светлана Васильевна</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, PhD</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент кафедры неврологии, психиатрии и наркологии</p></bio><email>kopishinskaya@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gustov</surname><given-names>A. V</given-names></name><name xml:lang="ru"><surname>Густов</surname><given-names>А. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Radyuk</surname><given-names>M. A</given-names></name><name xml:lang="ru"><surname>Радюк</surname><given-names>М. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">The Nizhniy Novgorod state medical academy of Minzdrav of Russia</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО "Нижегородская государственная медицинская академия" Минздрава РФ</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">The Volgograd state medical university of Minzdrav of Russia</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО "Волгоградский государственный медицинский университет" Минздрава РФ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2015</year></pub-date><volume>21</volume><issue>4</issue><issue-title xml:lang="en">VOL 21, NO4 (2015)</issue-title><issue-title xml:lang="ru">ТОМ 21, №4 (2015)</issue-title><fpage>53</fpage><lpage>56</lpage><history><date date-type="received" iso-8601-date="2020-07-21"><day>21</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО "Эко-Вектор"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://medjrf.com/0869-2106/article/view/38300">https://medjrf.com/0869-2106/article/view/38300</self-uri><abstract xml:lang="en"><p>The restless legs' syndrome or Willis-Ekbom disease is a wide-spread sensory-motor illness characterized by imperative wish to move legs and accompanied by dysesthesia. Until recently, restless legs' syndrome considered as a rare disease in view of poor recognizability of symptoms. The undiagnosed and untreated restless legs syndrome results in serious disorder of sleep. The physiopathology of restless legs syndrome is multi-factorial i.e. dysfunction of dopamine-ergic system, decreasing of iron in central nervous system, genetic susceptibility, disturbance of level of such neurotransmitters as hypocretins and endorphins, immune dysfunction, inflammation. The manifestations of restless legs' syndrome are sensory sensations and periodic movements in extremities during sleep of mode of flexion. The article presents main and additional criteria of restless legs' syndrome as well as associated signs of restless legs syndrome. The transdermal plaster rotigotine and pregabalin is a leader in pharmaceutical therapy.</p></abstract><trans-abstract xml:lang="ru"><p>Синдром беспокойных ног (СБН) или болезнь Виллиса-Экбома - это распространенное сенсорно-моторное заболевание, характеризующееся императивным желанием двигать ногами и сопровождающееся дизестезией. До недавнего времени СБН считался редким заболеванием ввиду плохой узнаваемости симптомов. Недиагностированный и нелеченый СБН приводит к серьезному нарушению сна. Патофизиология СБН мультифакториальна: дисфункция дофаминергической системы, снижение железа в ЦНС, генетическая предрасположенность, нарушение уровня таких нейротрансмиттеров, как гипокретины и эндорфины, иммунная дисфункция, воспаление. СБН бывает первичным и вторичным. Проявлениями СБН являются сенсорные ощущения и периодические движения в конечностях во время сна по типу сгибания. В статье приведены основные и дополнительные критерии СБН, а также ассоциированные признаки СБН. В медикаментозной терапии лидерами являются трансдермальный пластырь ротиготин и прегабалин.</p></trans-abstract><kwd-group xml:lang="en"><kwd>restless legs' syndrome</kwd><kwd>Willis-Ekbom disease</kwd><kwd>periodic movements</kwd><kwd>extremities</kwd><kwd>sleep</kwd><kwd>rotigotine</kwd><kwd>pregabalin</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>синдром беспокойных ног</kwd><kwd>болезнь Виллиса-Экбома</kwd><kwd>периодические движения в конечностях во время сна</kwd><kwd>ротиготин</kwd><kwd>прегабалин</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Nagandla K., De S. Restless legs syndrome: pathophysiology and modern management. Postgrad. Med. J. 2013; 89: 402-10.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Allen R.P. Screening for sleep disorders: recognising the features and presentations of restless legs syndrome. J. Clin. 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