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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Russian Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-2106</issn><issn publication-format="electronic">2412-9100</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">38348</article-id><article-id pub-id-type="doi">10.18821/0869-2106-2016-22-4-193-197</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The rationale application of donor material: original ten years experience, possible ways of development and literature data</article-title><trans-title-group xml:lang="ru"><trans-title>Рациональное использование донорского материала: собственный десятилетний опыт, возможные пути развития и данные литературы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Oganesyan</surname><given-names>Oganes G.</given-names></name><name xml:lang="ru"><surname>Оганесян</surname><given-names>Оганес Георгиевич</given-names></name></name-alternatives><bio xml:lang="en"><p>doctor of medical sciences, senior researcher of department of traumatology and reconstructive surgery</p></bio><bio xml:lang="ru"><p>доктор мед. наук, старший научный сотрудник отдела травматологии и реконструктивной хирургии ФГБУ «МНИИ ГБ им. Гельмгольца» Минздрава России</p></bio><email>oftalmolog@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yakovleva</surname><given-names>S. S</given-names></name><name xml:lang="ru"><surname>Яковлева</surname><given-names>С. С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kharlampidi</surname><given-names>M. P</given-names></name><name xml:lang="ru"><surname>Харлампиди</surname><given-names>М. П</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Grdikanyan</surname><given-names>A. A</given-names></name><name xml:lang="ru"><surname>Грдиканян</surname><given-names>А. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">The Helmholtz Moscow research institute of eyes diseases</institution></aff><aff><institution xml:lang="ru">ФГБУ «МНИИ ГБ им. Гельмгольца» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2016</year></pub-date><volume>22</volume><issue>4</issue><issue-title xml:lang="en">VOL 22, NO4 (2016)</issue-title><issue-title xml:lang="ru">ТОМ 22, №4 (2016)</issue-title><fpage>193</fpage><lpage>197</lpage><history><date date-type="received" iso-8601-date="2020-07-21"><day>21</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ООО "Эко-Вектор"</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://medjrf.com/0869-2106/article/view/38348">https://medjrf.com/0869-2106/article/view/38348</self-uri><abstract xml:lang="en"><p>Lately, layer-wise keratoplasty became the first operation of choice in case of pathology of cornea. In view of satisfying results of endothelial surgery similar operations are implemented at earlier stages that increases need in donor tissue. With increasing of life span of population, also increases number of patients in need of transplantation of cornea. The number of intact cadaver cornea decreases because of stable increase of surgical interventions on front segment of eye. The present article presents original ten years experience concerning optimization of application of donor tissue and indicate on possibilities of further increasing of number of applied keratoplasties. From 2009 to 2015 in the Helmholtz Moscow research institute of eyes diseases 652 transplantations of cornea were implemented in various modifications: straight-through keratoplasty, transplantation of Descemet's membrane with endothelium (DMEK), deep front layer-wise keratoplasty, endokeratoplasty (DSEK) with various modes of transplant formation and 23 frontal layer-wise keratoplasties. In transplantation were also used eyes of donors with radial keratotomy, after laser keratomileusis and with artificial intra-ocular lens. To implement 652 operations 528 cadaver eyes with average age 41 ± 32,5 years (varying from 21 to 87 years) were required. The number of transplantations increased approximately on 50% at potential up to 75%. The lamellar surgery permits using corneal donor tissue with altered frontal surface and to increase number of transplantations of cornea. The renunciation of application of corneal donor tissue with altered frontal surface is inexpedient.</p></abstract><trans-abstract xml:lang="ru"><p>В последние годы послойная кератопластика стала первой операцией выбора при селективной патологии роговицы. Ввиду удовлетворительных результатов эндотелиальной хирургии подобные операции выполняются на более ранних стадиях, что повышает потребность в донорской ткани. С увеличением продолжительности жизни населения количество пациентов, нуждающихся в пересадке роговицы, также возрастает, а количество интактных кадаверных роговиц уменьшается из-за стабильного увеличения хирургических вмешательств на переднем отрезке глаза. Цель данного материала - представить собственный десятилетний опыт оптимизации использования донорской ткани и указать на возможности по увеличению количества выполняемых кератопластик. За 7 лет (2009-2015 гг.) в нашем учреждении выполнены 652 трансплантации роговицы в различных модификациях: сквозная кератопластика, трансплантация десцеметовой мембраны с эндотелием (DMEK), глубокая передняя послойная кератопластика, эндокератопластика (DSEK) с различными способами формирования трансплантата и 23 передних послойных кератопластик. В трансплантации использованы также глаза доноров с радиальной кератотомией, после лазерного кератомилеза и с искусственной интраокулярной линзой. Для выполнения 652 операций понадобилось 528 кадаверных глаз со средним возрастом 41 ± 32,5 года (варьировал от 21 до 87 лет). Количество трансплантаций увеличилось приблизительно на 50% при потенциале до 75%. Ламеллярная хирургия позволяет использовать роговичную донорскую ткань с измененной передней поверхностью и увеличить количество трансплантаций роговицы. Отказ от применения роговичной донорской ткани с измененной передней поверхностью нецелесообразен.</p></trans-abstract><kwd-group xml:lang="en"><kwd>DSEK</kwd><kwd>DMEK</kwd><kwd>LASIK</kwd><kwd>donor</kwd><kwd>DSEK</kwd><kwd>DMEK</kwd><kwd>radial keratotomy</kwd><kwd>LASIK</kwd><kwd>endothelium keratoplasty</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>роговица</kwd><kwd>донор</kwd><kwd>радиальная кератотомия</kwd><kwd>эндотелиальная кератопластика</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Phillips P., Terry M., Shamie N., Chen E., Hoar K., Stoeger C. et al. Descemet’s stripping automated endothelial keratoplasty (DSAEK) using corneal donor tissue not acceptable for use in penetrating keratoplasty as a result of anterior stromal scars, pterygia, and previous corneal refractive surgical procedures. 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