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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Russian Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-2106</issn><issn publication-format="electronic">2412-9100</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">38431</article-id><article-id pub-id-type="doi">10.18821/0869-2106-2018-24-3-120-123</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">THE HEMOFILTRATION AT INFUSION THERAPY OF SEVERE ACUTE PANCREATITIS</article-title><trans-title-group xml:lang="ru"><trans-title>ГЕМОФИЛЬТРАЦИЯ ПРИ ИНФУЗИОННОЙ ТЕРАПИИ ТЯЖЕЛОГО ОСТРОГО ПАНКРЕАТИТА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ganert</surname><given-names>Andrey N.</given-names></name><name xml:lang="ru"><surname>Ганерт</surname><given-names>Андрей Николаевич</given-names></name></name-alternatives><bio xml:lang="en"><p>candidate of medical sciences, associate professor of the Chair of Anesthesiology and Reanimation “The Yaroslavl State Medical University”, 150000, Yaroslavl, Russian Federation</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры анестезиологии и реаниматологии ФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России, 150000, Ярославль</p></bio><email>anest08@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kokorev</surname><given-names>E. V</given-names></name><name xml:lang="ru"><surname>Кокорев</surname><given-names>Е. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zhbannikov</surname><given-names>P. S</given-names></name><name xml:lang="ru"><surname>Жбанников</surname><given-names>П. С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zabusov</surname><given-names>A. V</given-names></name><name xml:lang="ru"><surname>Забусов</surname><given-names>А. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">“The Yaroslavl State Medical University” of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2018</year></pub-date><volume>24</volume><issue>3</issue><issue-title xml:lang="en">VOL 24, NO3 (2018)</issue-title><issue-title xml:lang="ru">ТОМ 24, №3 (2018)</issue-title><fpage>120</fpage><lpage>123</lpage><history><date date-type="received" iso-8601-date="2020-07-21"><day>21</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, ООО "Эко-Вектор"</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://medjrf.com/0869-2106/article/view/38431">https://medjrf.com/0869-2106/article/view/38431</self-uri><abstract xml:lang="en"><p>The 64 patients with severe acute pancreatitis at admission in hospital arterial hypertension, low venous saturation of oxygen (ScvO2), hyperlactemia, oligoanuria and hypercreatininemia were observed. This occurrence became an indication for infusion therapy to recover and optimize hemodynamics. After 6 hours of therapy, 30 patients were lacked increasing of diuresis related to infusion load and hypercreatininemia increased and also significantly increased positive fluid balance s compared to other patients. These 30 patients were additionally applied hemofiltration during 66 hours. The infusion therapy was characterized by difficulty of restoration and optimization of hemodynamic, large volumes of infusion mediums та frequent application of sympathomimetics. In patients without hemofiltration a significant increasing of cumulative fluid balance was added. The hemofiltration permitted to normalize diuresis, to prevent surplus cumulation of fluid and to support blood circulation at the optimal level.</p></abstract><trans-abstract xml:lang="ru"><p>У 62 пациентов с тяжёлым острым панкреатитом при поступлении отмечались артериальная гипотензия, низкая венозная сатурация кислорода (ScvO2), гиперлактатемия, олигоанурия, гиперкреатининемия, что явилось показанием к инфузионной терапии для восстановления и оптимизации гемодинамики. Через 6 ч терапии у 30 пациентов отсутствовало увеличение диуреза на инфузионную нагрузку, возрастала гиперкреатининемия, и значительно увеличивался положительный жидкостный баланс по сравнению с таковым у других пациентов. Этим 30 пациентам дополнительно проводилась гемофильтрация (ГФ) в течение 66 ч. Инфузионная терапия характеризовалась трудностью восстановления и оптимизации гемодинамики, большими объёмами инфузионных сред и частым использованием симпатомиметиков. У пациентов без ГФ это сопровождалось существенным возрастанием кумулятивного жидкостного баланса. ГФ позволила нормализовать диурез, предупредить избыточную кумуляцию жидкости и поддержать кровообращение на оптимальном уровне.</p></trans-abstract><kwd-group xml:lang="en"><kwd>severe acute pancreatitis</kwd><kwd>infusion therapy</kwd><kwd>fluid balance</kwd><kwd>hemofiltration</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>тяжелый острый панкреатит</kwd><kwd>инфузионная терапия</kwd><kwd>жидкостный баланс</kwd><kwd>гемофильтрация</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Banks P., Bollen T., Dervenis C., Gooszen H.G., Johnson C.D., Sarr M.G. et al. Classification of acute pancreatitis 2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013; 62(1): 102-11.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Zerem E. 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