Russian MedicineRussian MedicineРоссийский медицинский журнал0869-21062412-9100Eco-Vector5960210.17816/0869-2106-2020-26-5-292-297Clinical medicineКлиническая медицинаResearch ArticleUric acid as a prognostic marker in elderly patients with an exacerbation of coronary artery diseaseМочевая кислота как прогностический маркер у больных пожилого возраста, перенесших обострение ишемической болезни сердцаhttps://orcid.org/0000-0001-8377-1350ZubovaEkaterina A.ЗубоваЕкатерина Андреевна
Russian Federation
zubova.katerinka@inbox.ruBrazhnikVictoria A.БражникВиктория Алексеевна
Russian Federation

MD, PhD

к.м.н.

vabrahznik@bk.ruMinushkinaLarisa O.МинушкинаЛариса Олеговна
Russian Federation

MD, PhD, DSc, Professor

д.м.н., профессор

minushkina@mail.ruhttps://orcid.org/0000-0002-8867-117XAverkovaAnastasia О.АверковаАнастасия Олеговна
Russian Federation

MD, PhD

к.м.н.

avek@mail.ruhttps://orcid.org/0000-0001-7065-2045ZateyshchikovDmitry A.ЗатейщиковДмитрий Александрович
Russian Federation

MD, PhD, DSc, Professor

д. м. н., профессор

dz@bk.ruCity Сlinical Hospital № 51ГБУЗ «Городская клиническая больница № 51 Департамента здравоохранения г. Москвы»Central State Medical AcademyФГБОУ ДПО «Центральная государственная медицинская академия» Управления делами Президента РФM.V. Lomonosov Moscow Sstate UuniversityФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»281020202652922972801202128012021Copyright ©; 2020, Eco-VectorCopyright ©; 2020, ООО "Эко-Вектор"2020Eco-VectorООО "Эко-Вектор"https://medjrf.com/0869-2106/article/view/59602

The search for causal factors that can influence the prognosis after an acute coronary syndrome in elderly patients is a critical task. This study aimed to assess the correlation between increased uric acid levels with the incidence of adverse outcomes in patients over 75 years of age with history of acute coronary syndrome. Medical Records of 343 patients over 75 years old with history of acute coronary syndrome were retrospectively reviewed. Clinical characteristics and laboratory data upon admission, whether deceased or survived, were also analyzed. When carrying out multivariate analysis, following factors independently associated with total mortality were analyzed: aortic stenosis, atrial fibrillation, hyperglycemia, and acute heart failure at the moment of the index event, hyperuricemia, and percutaneous coronary intervention at the time of hospitalization caused by the index event. Thus, an increase in the level of uric acid is an independent predictor of lethality in the senior age group patients.

Поиск факторов, способных оказать влияние на прогноз после перенесенного острого коронарного синдрома у пациентов пожилой группы, является актуальной задачей. Целью данного исследования стала оценка ассоциации повышения уровня мочевой кислоты с частотой неблагоприятных исходов у пациентов старше 75 лет, перенесших острый коронарный синдром. Проанализированы данные 343 пациентов c острым коронарным синдромом старше 75 лет. Проанализированы клинические характеристики и лабораторные данные при поступлении умерших и выживших больных. При проведении многофакторного анализа факторами, независимо ассоциированными с общей смертностью, оказались наличие у больных аортального стеноза, мерцательной аритмии, гипергликемии и острой сердечной недостаточности при индексном событии, гиперурикемия, чрескожное коронарное вмешательство при индексной госпитализации. Таким образом, повышение уровня мочевой кислоты является независимым предиктором смерти пациентов старшей возрастной группы.

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