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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Russian Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-2106</issn><issn publication-format="electronic">2412-9100</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">629544</article-id><article-id pub-id-type="doi">10.17816/medjrf629544</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original Research Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Facial nerve neuropathy during the COVID-19 pandemic: clinical features, acupuncture treatment approaches</article-title><trans-title-group xml:lang="ru"><trans-title>Невропатия лицевого нерва в период пандемии COVID-19: клинические особенности, рефлексотерапевтические подходы в лечении</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0350-3063</contrib-id><contrib-id contrib-id-type="researcherid">I-4820-2016</contrib-id><contrib-id contrib-id-type="spin">7128-6905</contrib-id><name-alternatives><name xml:lang="en"><surname>Andreeva</surname><given-names>Galina O.</given-names></name><name xml:lang="ru"><surname>Андреева</surname><given-names>Галина Олеговна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>д-р мед. наук</p></bio><email>galinandreev@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7314-7711</contrib-id><contrib-id contrib-id-type="scopus">7003327776</contrib-id><contrib-id contrib-id-type="researcherid">I-6024-2016</contrib-id><contrib-id contrib-id-type="spin">1155-9732</contrib-id><name-alternatives><name xml:lang="en"><surname>Odinak</surname><given-names>Miroslav M.</given-names></name><name xml:lang="ru"><surname>Одинак</surname><given-names>Мирослав Михайлович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), professor, corresponding member of the Russian Academy of Sciences</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, член-корреспондент РАН</p></bio><email>odinak@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2907-3129</contrib-id><contrib-id contrib-id-type="spin">5900-4225</contrib-id><name-alternatives><name xml:lang="en"><surname>Litvinenko</surname><given-names>Elena V.</given-names></name><name xml:lang="ru"><surname>Литвиненко</surname><given-names>Елена Валентиновна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>elenalitv@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3109-8795</contrib-id><contrib-id contrib-id-type="scopus">57203881632</contrib-id><contrib-id contrib-id-type="researcherid">I-4819-2016</contrib-id><contrib-id contrib-id-type="spin">7779-3569</contrib-id><name-alternatives><name xml:lang="en"><surname>Lobzin</surname><given-names>Vladimir Y.</given-names></name><name xml:lang="ru"><surname>Лобзин</surname><given-names>Владимир Юрьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>vladimirlobzin@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shishkina</surname><given-names>El'vira V.</given-names></name><name xml:lang="ru"><surname>Шишкина</surname><given-names>Эльвира Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>elllia@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Military Medical Academy named after S.M. Kirov</institution></aff><aff><institution xml:lang="ru">Военно-медицинская академия имени С.М. Кирова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">St Petersburg University</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский государственный университет</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">City Consultative and Diagnostic Center No. 1, Saint Peterburg</institution></aff><aff><institution xml:lang="ru">Городской консультативно-диагностический центр № 1, Санкт-Петербург</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-05-31" publication-format="electronic"><day>31</day><month>05</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-07-10" publication-format="electronic"><day>10</day><month>07</month><year>2024</year></pub-date><volume>30</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>218</fpage><lpage>227</lpage><history><date date-type="received" iso-8601-date="2024-03-28"><day>28</day><month>03</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-05-12"><day>12</day><month>05</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Эко-Вектор</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2027-07-10"/></permissions><self-uri xlink:href="https://medjrf.com/0869-2106/article/view/629544">https://medjrf.com/0869-2106/article/view/629544</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND</bold>: Facial nerve neuropathy (FNN) is a common mononeuropathy in the general stage of development of the peripheral nervous system. During the novel coronavirus disease (COVID-19) pandemic, the incidence of facial neuropathy increased from 1.3% in 2019 to 3.5% in 2020. Acute isolated neuropathy of the facial nerve may be the first and only manifestation of various infectious diseases, including COVID-19. Several experts showed that the mechanisms of facial neuropathy development after a coronavirus infection is associated with neuroinflammation.</p> <p>Accepted therapeutic algorithms do not always lead to the expected results. Acupuncture potentially plays a key role in the treatment of this disease. In several cases, its superiority over drug treatment for FNN has been noted. No Russian studies on the treatment of post-COVID FNN were found.</p> <p><bold>AIM</bold>: This study aimed to study the clinical features of the course of FNN after COVID-19, develop reflexology approaches to treatment, and compare the course of FNN between patients with a history of coronavirus infection and those without a history of COVID-19 infection.</p> <p><bold>MATERIALS AND METHODS</bold>: The study group (after COVID-19) consisted of 16 patients with FNN (13 men, 3 women). The comparison group included 21 patients with FNN without a history of COVID-19 (15 men, 6 women). For a comprehensive patient assessment, clinical, neurological, and electroneuromyographic examination data were used.</p> <p><bold>RESULTS</bold>: The treatment results of 16 patients with FNN that developed up to 12 weeks after suffering from COVID-19 were analyzed. The onset of the disease was accompanied by an arterial hypertension episode, which was observed for the first time in two patients. Nerve fiber damage was mixed and severe (&gt;52%). The dynamics of clinical and electrophysiological parameters in the study group (after COVID-19) were significantly slower compared to that of the group without a history of COVID.</p> <p><bold>CONCLUSION</bold>: FNN that develops after COVID-19 is characterized by severe nerve fibers damage and a long course. Reflexology is an effective and safe method as part of complex therapy.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование</bold>. Невропатия лицевого нерва (НЛН) — один из наиболее распространённых видов мононевропатий в общей структуре заболеваний периферической нервной системы. В период пандемии новой коронавирусной инфекции (COVID-19) частота заболеваемости НЛН возросла с 1,3% в 2019 году до 3,5% в течение 2020 года.</p> <p>Развитие острой изолированной НЛН может быть первым и единственным проявлением различных инфекционных заболеваний, в том числе и COVID-19. Большинство экспертов связывают механизмы развития НЛН после перенесённой коронавирусной инфекции с наличием нейровоспаления.</p> <p>Принятые терапевтические алгоритмы не всегда приводят к желаемому результату. Роль акупунктуры может быть ключевой в лечении данного заболевания. В ряде случаев отмечено её превосходство над медикаментозным лечением при НЛН. В русскоязычной литературе мы не обнаружили работ, посвящённых лечению постковидной НЛН.</p> <p><bold>Цель исследования</bold> — изучить клинические особенности течения НЛН после перенесённой COVID-19, выработать рефлексотерапевтические подходы в лечении, сравнить течение НЛН у пациентов с перенесённой коронавирусной инфекцией и без COVID-19 в анамнезе.</p> <p><bold>Материалы и методы</bold>. Группу исследования (после COVID-19) составили 16 больных с НЛН (13 мужчин и 3 женщины). В группу сравнения был включён 21 пациент с НЛН без COVID-19 в анамнезе (15 мужчин и 6 женщин). Для комплексной оценки больных использовали данные клинического, неврологического, электронейромиографического обследования.</p> <p><bold>Результаты</bold>. Проанализированы результаты лечения 16 больных с НЛН, развившейся в сроки до 12 нед после перенесённой коронавирусной инфекции. Дебют заболевания сопровождался эпизодом артериальной гипертензии, у двух пациентов отмечавшимся впервые. Поражение нервных волокон носило смешанный характер и имело выраженную степень (более 52%). Динамика клинических и электрофизиологических показателей в группе исследования (после COVID-19) была достоверно менее значимой по сравнению с группой без COVID-19 в анамнезе. Установлено, что применение общепринятых рефлексотерапевтических методик в лечении постковидной НЛН недостаточно эффективно. При этом включение в схему акупунктуры воздействия на группы точек для активации процессов саногенеза и методики многоигольчатого подкожного воздействия (по Г.О. Андреевой) для профилактики развития контрактур имело выраженный клинический эффект. Однако сроки восстановления функции лицевого нерва у пациентов после перенесённой коронавирусной инфекции были статистически значимо более длительными по сравнению с пациентами без COVID. Установлена необходимость повторных курсов рефлексотерапии.</p> <p><bold>Заключение</bold>. НЛН, развивающаяся после COVID-19, отличается выраженным поражением нервных волокон, длительным течением. Рефлексотерапия является эффективным и безопасным методом в составе комплексной терапии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>peripheral facial paralysis</kwd><kwd>COVID-19</kwd><kwd>post-COVID-19 syndrome</kwd><kwd>acupuncture</kwd><kwd>treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>невропатия лицевого нерва</kwd><kwd>COVID-19</kwd><kwd>постковидный синдром</kwd><kwd>рефлексотерапия</kwd><kwd>лечение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Zammit M, Markey A, Webb C. A rise in facial nerve palsies during the coronavirus disease 2019 pandemic. J Laryngol Otol. doi: 10.1017/S0022215120002121</mixed-citation><mixed-citation xml:lang="ru">Zammit M., Markey A., Webb C. A rise in facial nerve palsies during the coronavirus disease 2019 pandemic // J Laryngol Otol. 2020. Vol. 134. 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