Russian MedicineRussian Medicine0869-21062412-9100Eco-Vector6501310.17816/0869-2106-2020-26-6-359-363Research ArticleExperiences of testing immunoglobulins to the SARS-CoV-2 virus in outpatient practiceMinushkinaLarisa O.<p>MD, PhD, DSc, Professor</p>minushkina@mail.ruhttps://orcid.org/0000-0002-4203-3586GrigorievaElena V.<p>MD, PhD</p>gev0160@mail.ruMukharevaAynagyul D.amukh@mail.ruKuleshovaSvetlana V.svkul@mail.ruhttps://orcid.org/0000-0002-6743-9574Central State Medical Academy of the Department of Presidential AffairsPolyclinic No. 2 of the Department of Presidential Affairs151220202663593630904202109042021Copyright © 2020, Eco-Vector2020<p><strong><em>The study aimed</em></strong><strong> to analyze the results of testing the presence of immunoglobulins of severe acute respiratory syndrome coronavirus 2 infection in outpatient clinical practice. The data of all tests of immunoglobulins <em>G </em>and <em>M </em>performed in the laboratory of Polyclinic No. 2 of the Administrative Department of the President of the Russian Federation from June 5 to October 2, 2020, were analyzed. In total, the studies were conducted in 784 applicants (319 [40.7%] men and 465 [59.3%] women), with the average age of 48.4614.044 years (18 to 89 years). Of patients, 317 were clinically diagnosed with a new coronavirus infection, 64 were examined as having contacted the infected, 83 had bronchopulmonary diseases, and 320 were healthy individuals. A positive test result for the presence of IgG antibodies was obtained in 87.7% of patients with a new coronavirus infection. Of cases, 96.3% had a typical X-ray presentation of viral pneumonia that was confirmed by the polymerase chain reaction method, and also, 5% of cases in the healthy group. The data obtained enabled us to establish high sensitivity of the test systems used.</strong></p>immunoglobulinsSARS-CoV-2coronavirus infectionIgMIgGиммуноглобулиныSARS-CoV-2коронавирусная инфекцияIgMIgG[Devyatkin AV, Devyatkin AA. A novel coronavirus infection – COVID-19. Origin, tropism, transmission, routes, lab diagnostics and specific care. Kremlevskaya meditsina. Klinicheskii vestnik. 2020;(2):5–13. (In Russ). doi: 10.26269/b9ve-xf49.][Kuvshinova IN, Nekrasov BG, Livitskaya NI, Molodykh SV, Rukavishnikov MYu. Sensitivity and specificity of VEKTOR-BEST JSC reagent kits for the detection of immunoglobulins of different classes in SARS-COV-2. Spravochnik zaveduyushchego KDL. 2020;(10):27–32. (In Russ).][Kuleshova SV, Grigorieva EV, Mukharaeva AD, Minushkina LO. Experience in determining antibodies to the SARS-COV-2 virus - the causative agent of a new coronavirus infection. Spravochnik zaveduyushchego KDL. 2020;(9):9–15. (In Russ).][Balakhonov SV, Dubrovina VI, Chesnokova MV, Voitkova VV, Pyatidesyatnikova AB, Bryukhova DD, et al. Studying humoral immune response at mild and asymptomatic COVID-19 forms. Acta biomedica scientifica. 2020;5(5):26–30. (In Russ). doi: 10.29413/ABS.2020-5.5.3][Li Z, Yi Y, Luo X, Xiong N, Liu Y, Li S, Sun R, et al. Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. J Med Virol. 2020:1518-1524. doi: 10.1002/jmv.25727.][Tré-Hardy M, Wilmet A, Beukinga I, Favresse J, Dogné JM, Douxfils J, Blairon L. Analytical and clinical validation of an ELISA for specific SARS-CoV-2 IgG, IgA and IgM antibodies. J Med Virol. 2020:803-811. doi: 10.1002/jmv.26303.][Kohmer N, Westhaus S, Rühl C, Ciesek S, Rabenau HF. Clinical performance of different SARS-CoV-2 IgG antibody tests. J Med Virol. 2020:2243-2247. doi: 10.1002/jmv.26145.][Popova AYu, Ezhlova EB, Mel’nikova AA, Bashketova NS, Fridman RK, Lyalina LV, et al. Herd immunity to SARS-CoV-2 among the population in Saint-Petersburg during the COVID-19 epidemic. Problemy osobo opasnykh infektsi. 2020;(3):124–130. (In Russ). doi: 10.21055/0370-1069-2020-3-124-130.][Popova AYu, Ezhlova EB, Mel’nikova AA, Istorik OA, Mosevich OS, Lyalina LV, et al. Assessment of the herd immunity to SARS-CoV-2 among the population of the Leningrad Region during the COVID-19 epidemic. Problemy osobo opasnykh infektsii. 2020;(3):114–123. (In Russ). doi: 10.21055/0370-1069-2020-3-114-123.]