<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Russian Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-2106</issn><issn publication-format="electronic">2412-9100</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">678539</article-id><article-id pub-id-type="doi">10.17816/medjrf678539</article-id><article-id pub-id-type="edn">ABHLYW</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original Research Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Effect of surgical correction of nasal cavity pathologic changes on obstructive sleep apnea syndrome severity in patients after laser-assisted uvulopalatoplasty</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние хирургической коррекции патологических изменений в полости носа у больных, перенёсших лазерную скульптурную увулопалатопластику, на уменьшение степени тяжести синдрома обструктивного апноэ сна</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5742-3459</contrib-id><contrib-id contrib-id-type="spin">9303-5321</contrib-id><name-alternatives><name xml:lang="en"><surname>Knyazkov</surname><given-names>Vladimir B.</given-names></name><name xml:lang="ru"><surname>Князьков</surname><given-names>Владимир Борисович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>v.b.knyazkov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-2382-2879</contrib-id><name-alternatives><name xml:lang="en"><surname>Zhigzhitov</surname><given-names>Bair A.</given-names></name><name xml:lang="ru"><surname>Жигжитов</surname><given-names>Баир Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>bair-108@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian University of Medicine</institution></aff><aff><institution xml:lang="ru">Российский университет медицины</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">National Medical Research Center for Rehabilitation and Balneology</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр реабилитации и курортологии</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-06-20" publication-format="electronic"><day>20</day><month>06</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-06-11" publication-format="electronic"><day>11</day><month>06</month><year>2025</year></pub-date><volume>31</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>218</fpage><lpage>226</lpage><history><date date-type="received" iso-8601-date="2025-04-14"><day>14</day><month>04</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-05-28"><day>28</day><month>05</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-07-11"/></permissions><self-uri xlink:href="https://medjrf.com/0869-2106/article/view/678539">https://medjrf.com/0869-2106/article/view/678539</self-uri><abstract xml:lang="en"><p><bold>Background:<italic> </italic></bold>Nasal obstruction plays an important role in the pathogenesis of rhonchopathy. Narrowing of the nasal cavity, in the presence of certain pathological changes in it, leads to increased resistance to the inspiratory airflow. However, surgical correction of these changes in patients with rhonchopathy and obstructive sleep apnea syndrome does not necessarily reduce pharyngeal obstruction, and the absence of improvement in obstructive sleep apnea syndrome severity following surgical relief of nasal obstruction indicates the ineffectiveness of the intervention.</p> <p><bold>Aim:<italic> </italic></bold>This study aimed to evaluate the effect of surgical correction of pathological changes in the nasal cavity on the reduction of obstructive sleep apnea syndrome severity in patients after laser-assisted uvulopalatoplasty (LAU).</p> <p><bold>Methods:<italic> </italic></bold>Active anterior rhinomanometry results were analyzed and correlated with data from computer-based pulse oximetry and polysomnography in 72 patients aged 37 to 75 years with rhonchopathy and obstructive sleep apnea syndrome who had undergone LAU and were followed for 5 years. The patients were divided into 3 groups: group 1 (<italic>n</italic> = 20) included individuals with uncomplicated snoring, normal nasal breathing, no nasal cavity pathology, and no comorbidities; group 2 (<italic>n</italic> = 26) included patients without comorbidities who, based on clinical indications, underwent preliminary correction of pathologic changes in the nasal cavity (septoplasty, turbinate reduction, or polypectomy), followed by LAU 2 to 6 months later; and group 3 (<italic>n</italic> = 26) included patients with nasal obstruction and comorbidities who, based on clinical indications, underwent combined single-stage surgery consisting of LAU and correction of pathologic changes in the nasal cavity.</p> <p><bold>Results:<italic> </italic></bold>The study showed that, despite the positive effect of surgeries to relieve nasal obstruction—confirmed by active anterior rhinomanometry—and subjective improvement in sleep quality and general well-being reported by the vast majority of operated patients in groups 2 and 3 (45 [86.5%]), a reduction in obstructive sleep apnea syndrome severity after LAU was objectively confirmed by computer-based pulse oximetry and polysomnography in only 18 of 52 patients (34.6%) with obstructive sleep apnea syndrome of varying severity.</p> <p><bold>Conclusion:<italic> </italic></bold>Surgical correction of pathologic changes of the nasal cavity reduces the severity of obstructive sleep apnea syndrome in patients who have undergone LAU in only 34.6% of cases.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование. </bold>Носовая обструкция играет важную роль в патогенезе ронхопатии. Сужение полости носа при наличии тех или иных патологических изменений в ней приводит к увеличению сопротивления вдыхаемому потоку воздуха. Однако хирургическая коррекция этих изменений у больных ронхопатией и синдромом обструктивного апноэ сна не обязательно ведёт к уменьшению глоточной обструкции, а отсутствие изменений выраженности синдрома обструктивного апноэ сна после оперативного устранения носовой обструкции показывает неэффективность хирургического лечения.</p> <p><bold>Цель. </bold>Оценить влияние хирургической коррекции патологических изменений в полости носа на уменьшение степени тяжести синдрома обструктивного апноэ сна у больных, перенёсших лазерную скульптурную увулопалатопластику (ЛСУПП).</p> <p><bold>Методы. </bold>Проведён анализ результатов передней активной риноманометрии и определена их корреляция с данными мониторинговой компьютерной пульсоксиметрии и полисомнографии у 72 больных ронхопатией и синдромом обструктивного апноэ сна в возрасте от 37 до 75 лет, перенёсших ЛСУПП, при наблюдении за ними в течение 5 лет. Сформированы 3 группы исследуемых пациентов: 1-я (<italic>n</italic>=20) с неосложнённым храпом, нормальным носовым дыханием, без патологии в полости носа и сопутствующей соматической патологии; 2-я (<italic>n</italic>=26) без сопутствующей соматической патологии, пациентам которой по показаниям на предварительном этапе устранены патологические изменения в полости носа с помощью септопластики, коррекции носовых раковин, полипотомии, а в промежутке от 2 до 6 мес. выполнена ЛСУПП; 3-я (<italic>n</italic>=26) с затруднённым носовым дыханием и сопутствующей соматической патологией, пациентам которой по показаниям выполнена сочетанная одномоментная операция: ЛСУПП + устранение патологических изменений в полости носа.</p> <p><bold>Результаты. </bold>Исследование показало, что, несмотря на положительный эффект проведённых оперативных вмешательств по устранению носовой обструкции, подтверждённый результатами передней активной риноманометрии, субъективное улучшение качества сна и общесоматического состояния 45 (86,5%) оперированных больных из 2-й и 3-й групп — уменьшение тяжести синдрома обструктивного апноэ сна после выполнения ЛСУПП — объективно подтверждается результатами мониторинговой компьютерной пульсоксиметрии и полисомнографии лишь у 18 (34,6%) из 52 больных с синдромом обструктивного апноэ сна различной степени тяжести.</p> <p><bold>Заключение. </bold>Хирургическая коррекция патологических изменений в полости носа уменьшает тяжесть синдрома обструктивного апноэ сна у больных, перенёсших ЛСУПП, лишь в 34,6% случаев.</p></trans-abstract><kwd-group xml:lang="en"><kwd>rhonchopathy</kwd><kwd>obstructive sleep apnea syndrome</kwd><kwd>soft palate</kwd><kwd>laser radiation</kwd><kwd>laser-assisted uvulopalatoplasty</kwd><kwd>total volumetric airflow</kwd><kwd>total resistance</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ронхопатия</kwd><kwd>синдром обструктивного апноэ сна</kwd><kwd>мягкое нёбо</kwd><kwd>лазерное излучение</kwd><kwd>лазерная скульптурная увулопалатопластика</kwd><kwd>суммарный объёмный поток</kwd><kwd>суммарное сопротивление</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Elizarova LN, Grinchuk VI. Influence of obstructive changes in the nasal cavity on the aerodynamics of respiration in patients ronhopatiey. Rossiiskaya otorinolaringologiya. 2013;(5):34–38. EDN: RTHXWB</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Lopatin AS, Buzunov RV, Smushko AM, et al. Snoring and obstructive sleep apnea syndrome. Russian Rhinology. 1998;(4):17–33. (In Russ.)</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Khasanov US, Sharipov SS. Ronchopathy: a modern view on the pathogenesis of the disease. Molodoj uchjonyj. 2016;(14):243–247. (In Russ.) EDN: WFMHAD</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Lofaso F, Coste A, d'Ortho M, et. al. Nasal obstruction as a risk factor for sleep apnea syndrome. Eur Respir J. 2000;16(4):639–643. doi: 10.1034/j.1399-3003.2000.16d12.x</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Marshall NS, Wong KK, Liu PY, et al. Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study. Sleep. 2008;31(8):1079–1085.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Chandra RK, Patadia MO, Raviv J. Diagnosis of nasal airway obstruction. Otolaryngol Clin North Am. 2009;42(2):207–225, vii. doi: 10.1016/j.otc.2009.01.004</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Ul'yanov YuP. Local causes and effects of snoring. Mezhdunarodnyj medicinskij zhurnal. 1999;(1-2):108–111. (In Russ.)</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Ilium P. Septal deviation in snoring patients evaluated by acustic rhinometry. In: Proceedings of the 15th Congress of European Rhinologic Society, 13th ISLAN. 1994; Copengagen. P. 125.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Hoffstein V, Cole P. The effect of unilateral and bilateral nasal obstruction on snoring and sleep apnea. Laryngoscope. 1992;102(10):1150–1152. doi: 10.1288/00005537-199210000-00009</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Miljeteig H, Savard P, Mateika S, et al. Snoring and nasal resistance during sleep. Laryngoscope. 1993;103(8):918–923. doi: 10.1288/00005537-199308000-00015</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Piché J, Gagnon NB. Snoring, apnea, and nasal resistance. J Otolaryngol. 1996;25(3):150–154.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Li HY, Lin Y, Chen NH, et al. Improvement in quality of life after nasal surgery alone for patients with obstructive sleep apnea and nasal obstruction. Arch Otolaryngol Head Neck Surg. 2008;134(4):429–433. doi: 10.1001/archotol.134.4.429</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Sériès F, Pierre SST, Carrier G. Effects of surgical correction of nasal obstruction in the treatment of obstructive sleep apnea. Am Rev Respir Dis. 1992;146(5 Pt 1):1261–1265. doi: 10.1164/ajrccm/146.5_Pt_1.1261</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Sufioğlu M, Ozmen OA, Kasapoglu UL, et al. The efficacy of nasal surgery in obstructive sleep apnea syndrome: a prospective clinical study. Eur Arch Otorhinolaryngol. 2012;269(2):487–494. doi: 10.1007/s00405-011-1682-z EDN: JIZKTI</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Metes A, Ohki M, Cole P, et al. Snoring, apnea and nasal resistance in men and women. J Otolaryngol. 1991;20(1):57–61.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Virkkula P, Bachour A, Hytönen M, et al. Snoring is not relieved by nasal surgery despite improvement in nasal resistance. Chest. 2006;129(1):81–87. doi: 10.1378/chest.129.1.81</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Reshetnikova OV, Evseeva VV, Reshetnikov SV. Anterior active rhinomanometry in differential diagnostics of chronic rhinitis. Russian Rhinology. 2013;21(4):9–13. EDN: TBFFPJ</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Lu Y, Li S, Jin H, et al. High nasal resistance may be a result rather than a cause of obstructive sleep apnea. Eur Arch Otorhinolaryngol. 2014;271(11):2999–3003. doi: 10.1007/s00405-014-3061-z</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Welinder R, Cardell LO, Uddman R, Malm L. Reduced nasal airway resistance following uvulopalatoplasty. Rhinology. 1997;35(1):16–18.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Knyazkov VB, Prazdnikov EN, Stakhanov ML, et al. Laser sculptural uvulopalatoplasty as a new method of surgical treatment of snoring and obstructive sleep apnea syndrome. Russian Journal of Operative Surgery and Clinical Anatomy. 2023;7(1):5–12. doi: 10.17116/operhirurg202370115 EDN: BFZTAE</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Knyazkov VB, Prazdnikov EN, Daikhes NA. Selection of patients with snoring and obstructive sleep apnea syndrome for laser sculptural uvulopalatoplasty. Russian Journal of Operative Surgery and Clinical Anatomy. 2023;7(2):19–25. doi: 10.17116/operhirurg2023702119 EDN: BEJUXX</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Knyazkov VB, Prazdnikov EN, Daikhes NA. Reasonability in performing laser sculptural uvulopalatoplasty in patients with ronchopathy and obstructive sleep apnea syndrome. Lazernaya medicina. 2023;27(4):26–34. doi: 10.37895/2071-8004-2023-27-4-26-34 EDN: KHQFPI</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Andriy Ye, Igor Z, Alina N, Oleg G. Оgobjective evaluation of nasal breathing based on rhinomanometric data. Eastern-European Journal of Enterprise Technologies. 2014;4(9):47–51. doi: 10.15587/1729-4061.2014.26281 EDN: QNGKOD</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Derzhavina LL, Kozlov VS, Shilenkova VV. Acoustic rhinometry and anterior active rhinomanometry in the study of the nasal cycle. Russian Rhinology. 2002;(1):4–10. (In Russ.)</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Ellis PD. Laser palatoplasty for snoring due to palatal flutter: a further report. Clin Otolaryngol Allied Sci. 1994;19(4):350–351. doi: 10.1111/j.1365-2273.1994.tb01245.x</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Remacle M, Betsch C, Lawson G, et al. A new technique for laser-assisted uvulopalatoplasty: decision-tree analysis and results. Laryngoscope. 1999;109(5):763–768. doi: 10.1097/000055-37-199905000-00015</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Tardov MV, Kunelskaya NL, Turovsky AB, et al. Influence of rhinosurgery on the course of obstructive apnea syndrome. I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):106–110. doi: 10.17816/PAVLOVJ20153106-110 EDN: ULZTPJ</mixed-citation></ref></ref-list></back></article>
