Russian MedicineRussian MedicineРоссийский медицинский журнал0869-21062412-9100Eco-Vector70136810.17816/medjrf701368ArticlesСтатьиUnknownHydrogel systems and organoid models in regenerative dentistryГидрогелевые системы и органоидные модели в регенеративной стоматологииhttps://orcid.org/0009-0004-6522-3691AmirovaElvina A.АмироваЭльвина Алифхановна
Russian Federation

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eleya.ami@yandex.ruhttps://orcid.org/0009-0006-4870-6274DanevichDaria I.ДаневичДарья Игоревна
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dasha.26danevich@gmail.comhttps://orcid.org/0009-0005-5386-9070KukarkhoevaMadina B.КукархоеваМадина Бахаудиновна
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medinaedisultanova@gmail.comhttps://orcid.org/0009-0009-4830-7267VasilyevaAnastasia P.ВасильеваАнастасия Петровна
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anastasya-vasileva0@mail.ruhttps://orcid.org/0009-0002-7738-4527AlievaMaryamАлиеваМарям
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maryam.alieva.a@mail.ruhttps://orcid.org/0009-0001-2582-372XPtachekNatalia A.ПтачекНаталья Алексеевна
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ptachek.n@yandex.ruhttps://orcid.org/0009-0007-7461-8216TorshinMaksim N.ТоршинМаксим Николаевич
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torin223@yandex.ruhttps://orcid.org/0009-0007-7663-2783ChakhoyanSamvel A.ЧахоянСамвел Аршалуйсович
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samwelchakhoyan@mail.ruPavlov First Saint Petersburg State Medical UniversityПервый Санкт-Петербургский государственный медицинский университет им. И.П. ПавловаSaint Petersburg Medical and Social InstituteСанкт-Петербургский медико-социальный институтVoronezh State Medical University named after N. N. BurdenkoВоронежский государственный медицинский университет имени Н.Н. БурденкоKuban State Medical UniversityКубанский государственный медицинский университет01042026130720263232983142101202616022026Copyright ©; 2026, Eco-VectorCopyright ©; 2026, Эко-Вектор2026Eco-VectorЭко-Векторhttps://eco-vector.com/for_authors.php#07https://medjrf.com/0869-2106/article/view/701368

A retraction notice for this article is published at https://doi.org/10.17816/medjrf714011

Regenerative dentistry is an actively developing field aimed at restoring the structure and function of dental and periodontal tissues through biologically based approaches. Among the most promising strategies, hydrogel-based systems and organoid models have attracted increasing attention due to their ability to recreate key features of the native extracellular microenvironment and support controlled cellular behavior. This review summarizes current advances in the design and application of hydrogel systems and organoid technologies in dental tissue engineering, with an emphasis on their biological rationale, functional properties, and translational potential. Hydrogels represent versatile biomaterials capable of mimicking the physical and biochemical characteristics of the extracellular matrix, thereby providing a supportive scaffold for cell survival, proliferation, and lineage-specific differentiation. Recent developments in functional, stimuli-responsive, and composite hydrogels have expanded their applicability in the regeneration of dental pulp, dentin, periodontal tissues, and alveolar bone. In parallel, organoid models derived from dental and oral stem cell populations offer three-dimensional systems that recapitulate key aspects of tissue morphogenesis, enabling advanced studies of development, disease modeling, and drug screening. The integration of hydrogel platforms with organoid technologies has opened new opportunities for creating physiologically relevant and customizable regenerative constructs. Despite significant progress, challenges related to mechanical stability, vascularization, standardization, and clinical translation remain. Addressing these limitations through interdisciplinary research and technological refinement is essential for advancing regenerative strategies toward predictable and long-term clinical outcomes. Overall, hydrogel-based systems and organoid models represent complementary and powerful tools that may significantly reshape future approaches in regenerative dentistry.

Сообщение о ретракции этой статьи опубликовано по ссылке https://doi.org/10.17816/medjrf714011

Регенеративная стоматология является активно развивающимся направлением, ориентированным на восстановление структуры и функции тканей зубочелюстной системы с использованием биологически обоснованных подходов. В числе наиболее перспективных стратегий особое внимание в последние годы уделяется гидрогелевым системам и органоидным моделям, которые позволяют воспроизводить ключевые характеристики нативной внеклеточной микросреды и обеспечивать контролируемое поведение клеток. В настоящем обзоре обобщены современные данные о разработке и применении гидрогелевых биоматериалов и органоидных технологий в тканевой инженерии зубов, с акцентом на их биологические основы, функциональные свойства и трансляционный потенциал. Гидрогели представляют собой универсальные биоматериалы, способные имитировать физические и биохимические параметры внеклеточного матрикса, создавая благоприятные условия для выживания клеток, их пролиферации и направленной дифференцировки. Современные функциональные, стимул-чувствительные и композитные гидрогели расширили возможности регенерации пульпы зуба, дентина, тканей пародонта и альвеолярной кости. Параллельно развитие органоидных моделей на основе стволовых клеток зубных и околозубных тканей позволило создать трехмерные системы, воспроизводящие ключевые этапы морфогенеза, что делает их ценными инструментами для изучения развития, моделирования заболеваний и скрининга лекарственных препаратов. Интеграция гидрогелевых платформ с органоидными технологиями открывает новые перспективы создания физиологически релевантных и персонализированных регенеративных конструкций. Несмотря на значительный прогресс, сохраняются ограничения, связанные с механической стабильностью, васкуляризацией, стандартизацией и клинической трансляцией данных подходов. Их преодоление является необходимым условием для внедрения инновационных регенеративных решений в клиническую стоматологическую практику.

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