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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Russian Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-2106</issn><issn publication-format="electronic">2412-9100</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">72262</article-id><article-id pub-id-type="doi">10.17816/0869-2106-2021-27-1-57-65</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Lectures</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Лекции</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Anticoagulant therapy in patients with atrial fibrillation: management of bleeding</article-title><trans-title-group xml:lang="ru"><trans-title>Антикоагулянтная терапия у больных с фибрилляцией предсердий: тактика в случае развития кровотечений</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8309-8231</contrib-id><name-alternatives><name xml:lang="en"><surname>Zotova</surname><given-names>Irina V.</given-names></name><name xml:lang="ru"><surname>Зотова</surname><given-names>Ирина Вячеславовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>irinazotova@bk.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Center for Individualized Prevention and Treatment of Arterial and Venous Thrombosis, City Clinical Hospital Nо 17</institution></aff><aff><institution xml:lang="ru">Центр индивидуализированной профилактики и лечения артериальных и венозных тромбозов, Городская клиническая больница № 17</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Central State Medical Academy of department of presidential affairs of Russian Federation</institution></aff><aff><institution xml:lang="ru">Центральная государственная медицинская академия Управления делами Президента Российской Федерации</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2021</year></pub-date><volume>27</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>57</fpage><lpage>65</lpage><history><date date-type="received" iso-8601-date="2021-06-27"><day>27</day><month>06</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-06-27"><day>27</day><month>06</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Эко-Вектор"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2024-06-29"/></permissions><self-uri xlink:href="https://medjrf.com/0869-2106/article/view/72262">https://medjrf.com/0869-2106/article/view/72262</self-uri><abstract xml:lang="en"><p>Bleeding is the most common complication of long-term anticoagulant therapy. For patients with atrial fibrillation, it is important to consider the balance of hemorrhagic and thromboembolic risks in the event of bleeding since unreasonable withdrawal of anticoagulants can worsen the prognosis. The management of patients with hemorrhagic complications is determined according to the severity of bleeding, type of anticoagulant taken, and presence of high thromboembolic risk factors. The paper presents the author’s protocol for the management of patients with atrial fibrillation and various types of hemorrhagic complications against the background of anticoagulant therapy.</p></abstract><trans-abstract xml:lang="ru"><p>Кровотечения являются наиболее частым осложнением длительной антикоагулянтной терапии. Для пациентов с фибрилляцией предсердий в случае развития кровотечений важно учитывать баланс геморрагического и тромбоэмболического рисков, так как необоснованная отмена антикоагулянтов может ухудшить прогноз. Тактика ведения пациентов с геморрагическими осложнениями определяется тяжестью кровотечения, типом принимаемого антикоагулянта и наличием факторов высокого тромбоэмболического риска. В статье приведен авторский протокол ведения больных с фибрилляцией предсердий и различными типами геморрагических осложнений на фоне антикоагулянтной терапии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>atrial fibrillation</kwd><kwd>warfarin</kwd><kwd>direct oral anticoagulants</kwd><kwd>bleeding</kwd><kwd>neutralization of the anticoagulant effect</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>варфарин</kwd><kwd>прямые оральные антикоагулянты</kwd><kwd>кровотечения</kwd><kwd>нейтрализация антикоагулянтного эффекта</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">scardio.ru [internet]. Atrial fibrillation and flutter. 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