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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Russian Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0869-2106</issn><issn publication-format="electronic">2412-9100</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">83030</article-id><article-id pub-id-type="doi">10.17816/0869-2106-2021-27-5-465-472</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical medicine</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клиническая медицина</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Analysis of morphological changes in gallbladder walls after endoscopic bile duct decompression</article-title><trans-title-group xml:lang="ru"><trans-title>Анализ морфологических изменений стенки желчного пузыря у пациентов после эндоскопического декомпрессионного вмешательства на желчных протоках</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4230-8033</contrib-id><contrib-id contrib-id-type="spin">8917-7732</contrib-id><name-alternatives><name xml:lang="en"><surname>Shabunin</surname><given-names>Alexey V.</given-names></name><name xml:lang="ru"><surname>Шабунин</surname><given-names>Алексей Васильевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor, Corresponding member of the Russian Academy of Sciences</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, член-корр. РАН</p></bio><email>info@botkinmoscow.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0335-1204</contrib-id><contrib-id contrib-id-type="spin">9554-5553</contrib-id><name-alternatives><name xml:lang="en"><surname>Tavobilov</surname><given-names>Mikhail M.</given-names></name><name xml:lang="ru"><surname>Тавобилов</surname><given-names>Михаил Михайлович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), assistant professor</p></bio><bio xml:lang="ru"><p>д.м.н., доцент</p></bio><email>botkintmm@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5142-1302</contrib-id><contrib-id contrib-id-type="spin">9877-4166</contrib-id><name-alternatives><name xml:lang="en"><surname>Karpov</surname><given-names>Alexey A.</given-names></name><name xml:lang="ru"><surname>Карпов</surname><given-names>Алексей Андреевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>botkin.karpov@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4996-5025</contrib-id><name-alternatives><name xml:lang="en"><surname>Ozerova</surname><given-names>Darya S.</given-names></name><name xml:lang="ru"><surname>Озерова</surname><given-names>Дарья Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>surgeon emergency department №75, graduate student of Surgery Department RMACPS</p></bio><bio xml:lang="ru"><p>врач-хирург отделения экстренной хирургической помощи №75, очный аспирант кафедры хирургии Российской медицинской академии непрерывного профессионального образования</p></bio><email>ozerova311@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Botkin Hospital</institution></aff><aff><institution xml:lang="ru">Городская клиническая больница им. С.П. Боткина</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education</institution></aff><aff><institution xml:lang="ru">Российская медицинская академия непрерывного профессионального образования</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2021</year></pub-date><volume>27</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>465</fpage><lpage>472</lpage><history><date date-type="received" iso-8601-date="2021-10-11"><day>11</day><month>10</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Эко-Вектор"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2024-09-15"/></permissions><self-uri xlink:href="https://medjrf.com/0869-2106/article/view/83030">https://medjrf.com/0869-2106/article/view/83030</self-uri><abstract xml:lang="en"><p><bold><italic>BACKGROUND</italic></bold><italic>:</italic> In patients who have undergone retrograde endoscopic choledocholithoextraction, technical difficulties are frequently encountered when performing laparoscopic cholecystectomy, which is associated with the development of destructive changes in the gallbladder wall. However, no studies on the assessment of morphological changes occurring in the gallbladder wall at different terms after endoscopic retrograde bile duct interventions are currently available in the literature. The relevance and insufficient knowledge of the research area prompted this study.</p> <p><bold><italic>AIM</italic></bold><italic>:</italic> This study aimed to determine the optimal terms of laparoscopic cholecystectomy after endoscopic bile duct decompression performed for cholelithiasis complicated by choledocholithiasis based on morphological changes in the gallbladder wall.</p> <p><bold><italic>MATERIALS AND METHODS</italic></bold><italic>:</italic> A comparative analysis of the pathological examination of 198 gallbladders removed surgically on different days after endoscopic bile duct decompression performed for cholelithiasis complicated by choledocholithiasis is presented.</p> <p><bold><italic>RESULTS</italic></bold><italic>:</italic> In group 1, cholecystectomy after endoscopic bile duct decompression was performed on days 1–3. Gallbladder wall changes were observed in 10 (12.8%) patients. In group 2, cholecystectomy was performed on days 4–7. Inflammatory changes were revealed in 13 (37.1%) preparations. Pathological examination of the surgical specimens of the patients in group 3 who underwent cholecystectomy on days 14–30 revealed changes in the gallbladder wall in 48 (56.4%) cases.</p> <p><bold><italic>CONCLUSIONS</italic></bold><italic>:</italic> Laparoscopic cholecystectomy after endoscopic bile duct decompression within the first 72 h is the most optimal.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование</bold>. Зачастую при выполнении лапароскопической холецистэктомии у пациентов, перенесших ретроградную эндоскопическую холедохолитоэкстракцию, возникают технические сложности, что связано с развитием деструктивных изменений в желчном пузыре. Однако в литературе на сегодняшний день отсутствуют исследования по оценке морфологических изменений, происходящих в стенке желчного пузыря на разных сроках после эндоскопического ретроградного вмешательства на желчных протоках. Актуальность темы и ее малоизученность побудили нас к проведению данного исследования.</p> <p><bold>Цель</bold> — определить оптимальные сроки выполнения лапароскопической холецистэктомии после эндоскопического декомпрессионного вмешательства на желчных протоках, выполняемого по поводу желчнокаменной болезни, осложненной холедохолитиазом, в зависимости от морфологических изменений, возникающих в стенке желчного пузыря.</p> <p><bold>Материалы и методы</bold>. Представлен сравнительный анализ патологоанатомического исследования 198 желчных пузырей, удаленных оперативным путем на разные сутки после эндоскопического декомпрессионного вмешательства на желчных протоках, выполняемого по поводу желчнокаменной болезни, осложненной холедохолитиазом.</p> <p><bold>Результаты</bold>. В 1-й группе холецистэктомия после эндоскопического декомпрессионного вмешательства на желчных протоках выполнялась на 1–3-е сутки. Изменения в стенки желчного пузыря были отмечены у 10 (12,8%) пациентов. Во 2-й группе холецистэктомия была выполнена на 4–7-е сутки. Изменения воспалительного характера были обнаружены в 13 (37,1%) препаратах. При патологоанатомическом исследовании операционного материала 3-й группы пациентов, которым холецистэктомию выполнили на 14–30-е сутки, изменения в стенке желчного пузыря были отмечены в 48 (56,4%) случаях.</p> <p><bold>Заключение</bold>. Наиболее оптимальным является выполнение лапароскопической холецистэктомии после эндоскопического декомпрессионного вмешательства на желчных протоках в течение первых 72 ч.</p></trans-abstract><kwd-group xml:lang="en"><kwd>gallbladder morphology</kwd><kwd>complicated cholelithiasis</kwd><kwd>endoscopic bile duct drainage</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>морфология желчного пузыря</kwd><kwd>осложненная форма желчнокаменной болезни</kwd><kwd>эндоскопическое дренирующее вмешательство на желчных протоках</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Aboulian A, Chan T, Yaghoubian A, et al. Early cholecystectomy safely decreases hospital stay in patients with mild gallstone pancreatitis: a randomized prospective study. 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