Biology BulletinBiology BulletinИзвестия Российской академии наук. Серия биологическая1026-34703034-5367The Russian Academy of Sciences68990310.31857/S1026347025050086ФИЗИОЛОГИЯ ЖИВОТНЫХ И ЧЕЛОВЕКАResearch ArticleBioinformatic and behavioral analysis of Pannexin 1 involvement in cutaneous perception in miceБиоинформатический и поведенческий анализ участия Паннексина 1 в кожной чувствительности у мышейKiryukhinaO. O.КирюхинаО. О.
Russian Federation
kcyu@yandex.ruTarasovaO. S.ТарасоваО. С.
Russian Federation
kcyu@yandex.ruPanchinYu. V.ПанчинЮ. В.
Russian Federation
kcyu@yandex.ruA.A. Kharkevich Institute for Information Transmission Problems, Russian Academy of SciencesИнститут проблем передачи информации им. А.А. Харкевича, Российская академия наукInstitute of Biomedical Problems, Russian Academy of SciencesИнститут медико-биологических проблем, Российская академия наукMoscow State University named after M.V. LomonosovМосковский государственный университет имени М.В. ЛомоносоваResearch Institute of Physical Chemistry and Biology named after A.N. BelozerskyНИИ ФХБ им. А.Н. Белозерского0409202555725792608202526082025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://medjrf.com/1026-3470/article/view/689903

To reveal new functions of pannexin 1 in the mouse nervous system, cell types with the most pronounced expression of the gene encoding this protein were identified by bioinformatic analysis. It turned out that sensory neurons PSNP3 and PSNP6 of the dorsal root ganglia have the highest expression levels of Panx1, as well as high expression of purinoreceptor p2rx3, and other genes associated with the perception of pain and skin itch. The scratch reflex induced by compound 48/80 was suppressed in Panx1 knockout mice compared to wild-type mice, confirming the involvement of Panx1 in the purinergic regulation of sensory nerve fibers responsible for itch perception.

Для выявления новых функций паннексина 1 в нервной системе мыши путем биоинформатического анализа идентифицировали типы клеток с наиболее выраженной экспрессией гена, кодирующего этот белок. Оказалось, что чувствительные нейроны PSNP3 и PSNP6 ганглиев дорсальных корешков обладают наиболее высокими уровнями экспрессии Panx1, а также высокими уровнями экспрессии пуринорецептора p2rx3 и других генов, связанных с восприятием кожного зуда. Чесательный рефлекс, индуцированный веществом 48/80, был подавлен у мышей с нокаутом гена Panx1 по сравнению с диким типом, что подтверждает участие Panx1 в пуринергической регуляции нервных волокон, ответственных за восприятие зуда.

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