Prevention of carbohydrate metabolism disorders in rats by florotannins complex of the marine brown alga Sargassum pallidum under acute alcohol impact
Sprygin V.G., Fomenko S.E., Kushnerova N.F.
Abstract
It is shown that the complex of florotannins isolated from the marine brown alga Sargassum pallidum protects the pool of the oxidized form of NAD+-NADP+ from depletion during acute alcohol impact. Restoration of NAD+/NADH ratio provided preservation of redox potential in liver, necessary level of oxidized forms of metabolites of lactate dehydrogenase and glycerol-3-phosphate dehydrogenase shuttle cycles for maintenance of reactions of aerobic glycolysis and gluconeogenesis, pentose phosphate cycle, promoted prevention of tissue hypoxia and normalization of blood glucose level. This provides a basis for recommending the use of florotannin complexes as a prophylactic agent to attenuate the toxic effects of ethanol.