Unveiling the Molecular Basis of Comorbidity of Atherosclerosis and Aortic Aneurysm at the Cellular and Molecular Levels

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Abstract

Aortic aneurysm (AA) and atherosclerosis (AS) are characterized by ambiguous comorbid relationships between them. This review discusses the molecular mechanisms of formation of these pathologies caused by heterogeneity, plasticity, intercellular interactions, embryonic origin and regional specificity of arterial cells, revealed using the approach of single-cell transcriptomics in humans and in model animals. The importance of interplay of genetic and environmental factors that determine the functional state of blood vessels and the development of pathology through dynamic changes in the cellular composition of arteries within the framework of an ontogenetically regulated spatio-temporal continuum is emphasized, which creates conditions for the formation of comorbidity between diseases. Understanding the key molecular mechanisms underlying the comorbidity of AA and AS is important for the development of new therapeutic strategies for these pathological conditions.

About the authors

A. N. Kucher

Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences

Author for correspondence.
Email: maria.nazarenko@medgenetics.ru
Tomsk, 634050 Russia

M. S. Nazarenko

Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: maria.nazarenko@medgenetics.ru
Tomsk, 634050 Russia

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