Adaptive reactivity of cerebral energy metabolism in individuals with vibration disease and diabetes mellitus type 2

Introduction. Knowledge of adaptation options on the example of the reactivity of cerebral energy metabolism (CEM) under stress is important for determining the features of the development of vibration disease in the comorbid course of diabetes mellitus type 2 (DM2), the success of recovery in the rehabilitation period.

Objective of the study was adaptation options using the example of cerebral energy metabolism reactivity under stress in individuals with vibration disease caused by the simultaneous effect of local and general vibration (SLGV) and type 2 diabetes mellitus.

Materials and methods. Features of adaptation under stress were studied by the method of neuroenergy mapping with the measurement of the level of constant potential (DC-potential level). Groups were formed: I (n = 94) — patients with SLGV, II (n = 38) — with comorbid pathology (SLGV and DM 2), III (n = 39) — with DM2.

Results. More than 60% of all examined patients were established to be characterized by a rigid response to physical and emotional stress. Adequate CEM recovery reaction in the posthyperventilation period in the predominant number of cases was observed only in group I. In patients of group II, perverse (39%) and rigid (32%) reactions of recovery of DC-potential level were more common, group III — perverted and excessive response (33 % and 28%, respectively), characterizing the disorder of physiological adaptation in the presence of DM2.

Limitations. The limitations of the work are presented in the form of a brief description of working conditions, lack of study of the impact of industrial noise on cerebral hemodynamics, insufficient depth of the study of foreign literature materials on the issue under study.

Conclusion. The comorbid course SLGV and DM2 causes a persistent impairment of adaptation to stress, which is confirmed by the rigidity of the DC-potential level in response to hyperventilation, quick verbal response test, and the inadequacy of response during the restoration of neuroenergy exchange in the posthyperventilation period.

Compliance with ethical standards. Examination of patients was carried out in accordance with the ethical standard of the Declaration of Helsinki of the world association “Ethical principles for conducting scientific medical research involving humans”, as amended in 2000. and “Rules of Clinical Practice in the Russian Federation”, approved by the Order of the Ministry of Health of the Russian Federation No. 266 dated 06/19/2003. All examined signed an informed consent to participate in the study and there is a conclusion of the local ethical committee (LEC) (protocol No. 5 dated 11/14/2012).

Contribution:
Shevchenko O.I. — formed the concept and design of the study, developed a study plan, formed a common base, collected and analyzed data on NEC, wrote and designed an article, formulated conclusions;
Lakhman O.L. — took part in the formation of the concept of the study, took part in editing the article.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: April 14, 2023 / Accepted: June 7, 2023 / Published: July 30, 2023