Assessment of the carcinogenic risk for the population of Ulan-Ude

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Introduction. Oncological pathology has a high medical and social significance, so it is important to study the conditions of its formation. The aim of the study was to evaluate the cumulative carcinogenic risk for the population of the administrative center of the Republic of Buryatia (Ulan-Ude).

Material and methods. The identification of the carcinogenic hazard caused by the entry of chemical ingredients into the ambient air was carried out in 2005-2015. The exposure assessment is based on long-term average annual concentrations of carcinogens in the air, drinking water, food. Indices of comparative carcinogenic hazard (HCR) and individual carcinogenic risk (ICR) are calculated.

Results. The huge engineering enterprises are sources of several substances with carcinogenic effects (formaldehyde, chrome VI, cadmium, niсkel, epichlorohydrin, etc.).The individual carcinogenic risk for residents of Ulan-Ude is included in the range unacceptable for the general population. The main pathway for chemical agents to enter the body is inhalation (79%). The greatest contribution to the total individual carcinogenic risk on admission from the air was made by formaldehyde, chromium VI and Benz(a)pyrene. Priority carcinogens coming from drinking water and food are arsenic, cadmium, lead.

Conclusion. Results of the assessment of individual carcinogenic risk in Ulan-Ude indicate an unacceptable level of the impact on the population. The assessment has a number of uncertainties, which determines the need to further improve the monitoring system for carcinogenic hazards.

Sobre autores

N. Efimova

East-Siberian Institute of Medical and Ecological Research

Autor responsável pela correspondência
Email: noemail@neicon.ru
ORCID ID: 0000-0001-7218-2147
Rússia

S. Khankharev

The Federal Service for Supervision of Consumer Rights Protection and Human Welfare for the Republic of Buryatia

Email: noemail@neicon.ru
Rússia

Vladimir Motorov

East-Siberian Institute of Medical and Ecological Research

Email: motorov.vova@gmail.com

MD, post-graduate student of the East-Siberian Institute of Medical and Ecological Research.

e-mail: motorov.vova@gmail.com

Rússia

E. Madeeva

The Federal Service for Supervision of Consumer Rights Protection and Human Welfare for the Republic of Buryatia

Email: noemail@neicon.ru
ORCID ID: 0000-0003-4837-301X
Rússia

Bibliografia

  1. International Agency for Research on Cancer). 2013. IARC Scientific Publication No. 161. Air Pollution and Cancer. (Available at 21.03.2018. https://www.iarc.fr/en/publications/book​s/sp161/AirPollutionandCancer161.pdf ).
  2. NovikovS.M., ShashinaT.A., DodinaN.S, Kislitsyn V.A., VorobiovaL.M, Goryaev D.V. et al. Comparative assessment of the multimedia cancer health risks caused by contamination of the Krasnoyarsk krai regions’ environment. Gigiena i sanitarija. 2015; 2: 88-92. (inRussian)
  3. Gorjaev D.V., Tihonova I.V., Fedoreev R.V., Novikova I.I., ErofeevJu.V. Risks in the cancer expansion in population of the Krasnoyarsk territory. Vestnik ural’skoj medicinskoj akademicheskoj nauki. 2015; 2: 29-31. (in Russian)
  4. Chimitdorzhieva T.N. Malignant neoplasms in the population of Buryatia Republic. Rossijskij onkologicheskij zhurnal. 2013; 2: 42-46. (in Russian)
  5. Boloshinov A.B., Makarova L.V., Hanhareev S.S., Madeeva E.V., Chudinova O.N. condition of the problem and the prospect of decrease in risk to health of the population from pollution of atmospheric air in the Baikal region. Gigiena i sanitarija. 2007; 5:.24-6. (in Russian)
  6. Khankhareev S.S., Bagayeva E.E., Madeeva E.V., Tkacheva M.V., GovorinaYu.V. The management of atmospheric air quality based on health risk assessment methodology (on the example of Ulan-Ude the Republics of Buryatia). Zdorov’ye naseleniya i sreda obitaniya. 2013; 5 (242):7-9. (in Russian)
  7. Krewski D., Westphal M., Andersen M. E., Paoli G.M., Chiu W.A., Al-Zoughool M. et al. A framework for the next generation of risk science. Environ Health Persp. 2014; 122 (8): 796-805. https://doi.org/10.1289/ehp.1307260.
  8. Onishhenko G.G., Zajceva N.V., Maj I.V., Andreeva E.E. Cluster systematization of the parameters of sanitary and epidemiological welfare of the population in the regions of the Russian Federation and the federal cities. Analiz riska zdorovyu. 2016; 1(13): 4-14. (in Russian)
  9. R 2.1.10.1920-04 Human health risk assessment from environmental chemicals. M.: Federal’nyj centr Gossanjepidnadzora Rossii; 2004. (in Russian)
  10. Tarmaeva I. Ju., Efimova N.V., Vasilovskij A.M., Bogdanova O.G. Food security and health of the population of Eastern Siberia. Novosibirsk: Nauka; 2014. (in Russian)
  11. Efimova N.V., TarmaevaI.Ju., Bogdanova O.G. Evaluation of food contamination in the Republic of Buryatia. Gigiena i sanitarija. 2015; 94 (3): 93-96. (in Russian)
  12. Ageeva N. V., Katkova M. N., Ivanickaja M. V. Inhalation cancer risk assessment for the population of contaminated areas of the Chelyabinsk region. Radiacijai risk (Bjulleten’ Nacional’nogo radiacionno-jepidemiologicheskogo registra). 2013; 22(1): 26-35. (in Russian)
  13. Chuenkova G.A., Karelin A.O., Askarov R.A., Askarova Z.F. Evaluation of the air pollution health risk for the population of the city of Ufa. Gigiena i sanitarija. 2015; 94 (3): 24-9. (in Russian)
  14. IARC. 2012. IARC monographs on the evaluation of carcinogenic risks to humans. Volume 100. A review of human carcinogens. Part F: chemical agents and related occupations. Lyon: International Agency for Research on Cancer.(Available at 01.05.2018. http://apps.who.int/bookorders/anglais/detart1.jsp?codlan=1&codcol=72&codcch=6100).
  15. EPA. Toxicological review of formaldehyde – inhalation assessment. Washington (DC): US Environmental Protection Agency. (Available at 01.05.2018 https://cfpub.epa.gov/ncea/iris2/chemicalLanding.cfm?substance_nmbr=419)
  16. Gentry P.R., Rodricks J.V., Turnbull D., Bachand A., Van L.C., Shipp A.M. et al. Formaldehyde exposure and leukemia: critical review and reevaluation of the results from a study that is the focus for evidence of biological plausibility. Crit Rev Toxicol. 2013; 43:661–670.
  17. Lan Q., Smith M.T., Tang X., Guo W., Vermeulen R., Ji Z., Hubbard A.E. et al. Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde. Carcinogenesis.2015;36:160–167.
  18. Mundt K., Dell L., Crawford L., 4th Gallagher A.E. Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013. Occup Environ Med. 2017; https://doi.org/10.1136/oemed-2016-104051 (Available at 10.05.2018. https://www.researchgate.net/scientific-contributions/2051106203)
  19. Klejn S.V., Vekovshinina S.A., Sboev A.S. Priority risk factors of drinking water and the related with it economical loss. Gigiena i sanitarija. 2016; 95(1):10-14. (in Russian)
  20. Thompson T., Fawell J., Kunikane S., Jackson, D., Appleyard S., Callan, P., Bartram J., Kingston P. Chemical safety of drinking-water: assessing priorities for risk management. Geneva: WHO, 2007. (Available at 08 01. 2018. http://www.ircwash.org/sites/default/files/WHO-2007-Chemical.pdf.).
  21. Mantha M., Yeary E., Trent J., Creed P.A., Kubachka K., Hanley T. et al. Estimating inorganic arsenic exposure from U.S. rice and total water intakes. Environ. Health Persp. 2017; 125. https://doi.org/10.1289/EHP418
  22. IARC. International agency for research on cancer. Agents Classified by the IARC Monographs. 2015.(Available at 08 01. 2018. http://monographs.iarc.fr/ENG/Classification).
  23. EWG Environmental Working Group. Chromium-6 in US tap water. 2010. (Available at 7.11.2015. http://www.ewg.org/research/chromium6-in-tap-water ).
  24. Naz A., Mishra B.K., Gupta S.K. Human health risk assessment of chromium in drinking water: a case study of Sukinda chromite mine, Odisha, India. Exposureand Health. 2016; 8 (2):253–264.
  25. Arsenic. WHO. 372. 2016. (Available at 12.01.2018http://who.int/mediacentre/factsheets/fs372/ru/)
  26. Satarug S., Swaddiwudhipong W., Ruangyuttikarn W., Nishijo M., Ruiz P. Modeling cadmium exposures in low - and high-exposure areas in Thailand. Environ Health Persp. 2013; 121: 531–536.
  27. Akerstrom M., Barregard L., Lundh T., Sallsten G. The relationship between cadmium in kidney and cadmium in urine and blood in an environmentally exposed population. Toxicol Appl Pharmacol. 2013; 268: 286–93.
  28. Arnich N., Sirot V., Rivière G., Jean J, Noël L., Guérin T., et al. Dietary exposure to trace elements and health risk assessment in the 2nd French Total Diet Study. Food Chem Toxicol. 2012; 50:2432-2449.
  29. Itoh H, Iwasaki M, Sawada N, Takachi R, Kasuga Y, Yokoyama S, et al. Dietary cadmium intake and breast cancer risk in Japanese women: a case – control study. Int. J. Hygiene Environ Health. 2014. 217(1): 70-7 https://doi.org/10.1016/j.ijheh.2013.03.010.
  30. Pope C.A. III, Burnett R.T., Thun M.J., Calle E.E., Krewski D., Ito K., et al. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA. 2002; 287: 1132–41.
  31. Raaschou-Nielsen O., Beelen R., Wang M., Hoek G., Andersen Z., Hoffmann B., et al. Particulate matter air pollution components and risk for lung cancer. EnvironInt. 2016; 87: 66–73.

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