Resonance Electron Capture by 5-Methyluridine and 3'-Deoxythymidine Molecules

M. V. Muftakhov; Муфтахов М. В.; R. F. Tuktarov; Туктаров Р. Ф.

doi:10.31857/S0044453723050187

Resonance Electron Capture by 5-Methyluridine and 3'-Deoxythymidine Molecules

Authors: Muftakhov M.V.¹, Tuktarov R.F.¹
Affiliations:
1. Institute of Molecule and Crystal Physics, Ufa Federal Research Center, Russian Academy of Sciences
Issue: Vol 97, No 5 (2023)
Pages: 685-692
Section: СТРОЕНИЕ ВЕЩЕСТВА И КВАНТОВАЯ ХИМИЯ
Submitted: 27.02.2025
Published: 01.05.2023
URL: https://medjrf.com/0044-4537/article/view/668742
DOI: https://doi.org/10.31857/S0044453723050187
EDN: https://elibrary.ru/MSUPHF
ID: 668742

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Abstract
About the authors
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Abstract

Negative ion mass spectrometry is used to study processes of resonant electron attachment by 5‑methyluridine and 3'-deoxythymidine nucleoside molecules in the electron 0–14 eV range of energies. It is established that they are similar to those in nucleosides studied earlier (uridine, deoxyuridine, thymidine). The main channels of the fragmentation of molecular ions are revealed, and the absolute cross sections for the formation of fragment ions are determined. It is found that the intensity of the breaking the glycosidic bond in 3'-deoxythymidine in the region of low energies is two and a half orders of magnitude below the one in stavudine, testifying to the prospect of replacing the antiretroviral drug stavudine with 3'-deoxythymidine if radiation therapy is required for oncological diseases contracted as complications of HIV.

Keywords

resonant electron capture, negative ions, nucleosides, 5-methyluridine, 3'-deoxythymidine, antiretroviral medicines

About the authors

M. V. Muftakhov

Institute of Molecule and Crystal Physics, Ufa Federal Research Center, Russian Academy of Sciences

Email: LMSNI@anrb.ru
450075, Ufa, Russia

R. F. Tuktarov

Institute of Molecule and Crystal Physics, Ufa Federal Research Center, Russian Academy of Sciences

Author for correspondence.
Email: LMSNI@anrb.ru
450075, Ufa, Russia

References

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