Amino catalysts in the synthesis of cross-linked silicone diclofenac-containing composites
- Авторлар: Farmazyan Z.M.1, Atabekyan M.L.1, Akobyan E.A.1, Topuzyan V.O.1, Arakelova E.R.2, Grigoryan S.L.2, Grigoryan S.G.1
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Мекемелер:
- Scientific and Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- National Polytechnic University of Armenia
- Шығарылым: Том 94, № 8 (2024)
- Беттер: 913-928
- Бөлім: Articles
- URL: https://medjrf.com/0044-460X/article/view/667348
- DOI: https://doi.org/10.31857/S0044460X24080051
- EDN: https://elibrary.ru/SBRGUA
- ID: 667348
Дәйексөз келтіру
Аннотация
Low molecular mono- and diamines (3-aminopropyltriethoxysilane, hexamethylenediamine, 1,4-diaminobutane), and high molecular weight polydimethylsiloxane with terminal amine groups were studied as catalysts in the synthesis of cross-linked composite films based on polydimethylsiloxane with terminal hydroxyl groups, tetraethoxysilane a cross-linking agent and containing sodium diclofenac as a physiologically active compound. Polyethylene glycol PEG200 was used as a hydrophilizing component for the hydrophobic silicone matrix. The chemical structure of amine catalysts and polyethylene glycol presence have significant effect on structure and properties of the composites, thereby determining the kinetics and degree of prolonged release of diclofenac from the films.
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Авторлар туралы
Z. Farmazyan
Scientific and Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: grigstepan@yahoo.com
ORCID iD: 0000-0001-9841-5586
Institute of Fine Organic Chemistry named after A. L. Mnjoyan
Армения, Yerevan, 0014M. Atabekyan
Scientific and Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: grigstepan@yahoo.com
ORCID iD: 0000-0002-5265-5469
Institute of Fine Organic Chemistry named after A. L. Mnjoyan
Армения, Yerevan, 0014E. Akobyan
Scientific and Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: grigstepan@yahoo.com
ORCID iD: 0000-0003-2409-1894
Institute of Fine Organic Chemistry named after A. L. Mnjoyan
Армения, Yerevan, 0014V. Topuzyan
Scientific and Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: grigstepan@yahoo.com
ORCID iD: 0000-0002-1721-1993
Institute of Fine Organic Chemistry named after A. L. Mnjoyan
Армения, Yerevan, 0014E. Arakelova
National Polytechnic University of Armenia
Email: grigstepan@yahoo.com
ORCID iD: 0000-0001-6640-8998
Армения, Yerevan, 0009
S. Grigoryan
National Polytechnic University of Armenia
Email: grigstepan@yahoo.com
ORCID iD: 0000-0001-6342-4060
Армения, Yerevan, 0009
S. Grigoryan
Scientific and Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Хат алмасуға жауапты Автор.
Email: grigstepan@yahoo.com
ORCID iD: 0000-0002-7193-9803
Institute of Fine Organic Chemistry named after A. L. Mnjoyan
Армения, Yerevan, 0014Әдебиет тізімі
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