Amyloid cardiomyopathy in the elderly: clinical options, difficulties in diagnosis and treatment

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This article analyzes the frequency and features of cardiac amyloidosis in the elderly. The morphology and pathogenesis of amyloid cardiomyopathy are presented. The features of the clinical picture of the heart and aortic lesions in systemic and local variants of amyloidosis are analyzed. Polymorbidity in older people, which complicates the diagnosis of cardiac amyloidosis and leads to a delay in treatment, is reviewed. The diagnostic methods of various types of cardiac amyloidosis are evaluated. Modern trends in the treatment of amyloidosis are presented.

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About the authors

Ol’ga A. Ettinger

N.I.Pirogov Russian National Research Medical University

Author for correspondence.
ORCID iD: 0000-0002-1237-3731


Russian Federation, 117997, Moscow

Gennadiy E. Gendlin

N.I.Pirogov Russian National Research Medical University

ORCID iD: 0000-0002-7846-1611

MD, PhD, DSc, Professor

Russian Federation, 117997, Moscow

Elena A. Stepanova

V.M. Buyanov Moscow City Clinical Hospital; Russian Medical Academy of Continuing Professional Education

ORCID iD: 0000-0001-7760-5858

врач-патологоанатом; ассистент кафедры патологической анатомии 

Russian Federation, 115056, Moscow; 125993, Moscow

Irina I. Ganieva

V.M. Buyanov Moscow City Clinical Hospital

ORCID iD: 0000-0002-2429-1629


Russian Federation, 115056, Moscow

Svetlana V. Borisovskaya

N.I.Pirogov Russian National Research Medical University; V.M. Buyanov Moscow City Clinical Hospital

ORCID iD: 0000-0002-9365-1472


Russian Federation, 117997,Moscow; 115056, Moscow

Il’ya G. Fedorov

N.I.Pirogov Russian National Research Medical University; V.M. Buyanov Moscow City Clinical Hospital



Russian Federation, 117997, Moscow; 115056, Moscow

Igor’ G. Nikitin

N.I.Pirogov Russian National Research Medical University; Medical and Rehabilitation Center

ORCID iD: 0000-0003-1699-0881

MD, PhD, DSc, Professor

Russian Federation, 125367, Moscow


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Supplementary files

Supplementary Files
1. Fig. 1. Pseudo-infarction ECG changes in a 71-year-old patient with AKMP.

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2. Figure 2. Echocardiogram of a patient with AL-amyloidosis, severe pseudohypertrophy of the left ventricle.

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3. Fig. 3. Electrocardiogram of a patient of 80 years with AKMP. QRS low voltage in limb leads and chest leads, LV wall thickness - 1.6 cm.

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4. Fig. 4. Deposits of amyloid in the atrium. Stained with hematoxylin and eosin (A) and Congo red in a bright field (B). SW × 20.

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5. Fig. 5. Deposits of amyloid in the atrium. Congo red stain, polarization microscopy. SW × 20.

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6. Fig. 6. Deposits of amyloid in the myocardium of the left ventricle. Stained with hematoxylin and eosin (A), Congo red - light (B) and polarization (C) microscopy. SW × 20.

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7. Fig. 7. Deposits of amyloid in the thyroid gland. Congo red stain - light (A) and polarization (B) microscopy. SW × 20.

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Регистрационный номер и дата принятия решения о регистрации СМИ: 01016 от 19.07.1995 г
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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