Humus acids are promising compounds for the creation of new antimicrobial drugs

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Abstract

Infectious diseases are still the leading causes of morbidity and mortality worldwide, which prompts the need to prioritize research and development of new antimicrobial drugs with high pharmacological activity and favorable safety profile. One of the key directions in this field is the study of the potential of natural compounds, such as humus acids. Recent studies have shown that humus acids can exhibit multidirectional activity against various microorganisms and demonstrate synergistic pharmacological interaction with other drugs.

This review aimed to present a generalized and systematic analysis of currently available information on the known pharmacological effects and possible mechanisms of the antibacterial, antiviral, and antifungal activities of humus acids.

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About the authors

Nikita S. Benderskii

Rostov State Medical University

Author for correspondence.
Email: cornance@yandex.ru
ORCID iD: 0000-0002-7636-1684
SPIN-code: 5966-0480

resident physician

Russian Federation, 29 Nakhichevansky Lane, 344022 Rostov-on-Don

Zahar S. Popov

Kuban State Medical University

Email: 23zahar@mail.ru
ORCID iD: 0000-0002-5956-1289
SPIN-code: 6574-6076

student

Russian Federation, Krasnodar

Darya A. Popova

Rostov State Medical University

Email: dr.darya_popova@rambler.ru
ORCID iD: 0000-0001-9193-1684

student

Russian Federation, Rostov-on-Don

Elena L. Movchan

Rostov State Medical University

Email: elena.kirgeeva@yandex.ru
ORCID iD: 0009-0007-4838-9165

student

Russian Federation, Rostov-on-Don

Elizabeth A. Anuchina

Rostov State Medical University

Email: anuchina.elizavetaa@mail.ru
ORCID iD: 0009-0007-0156-881X

student

Russian Federation, Rostov-on-Don

Valeria S. Shiryaeva

Rostov State Medical University

Email: valerytokareva@yandex.ru
ORCID iD: 0009-0005-2632-5959

student

Russian Federation, Rostov-on-Don

Julia V. Kozlovtseva

Rostov State Medical University

Email: julia.kozlovtseva@yandex.ru
ORCID iD: 0009-0008-6315-4230

student

Russian Federation, Rostov-on-Don

Maria A. Noskova

Rostov State Medical University

Email: maria08.98@mail.ru
ORCID iD: 0009-0009-6783-0707

student

Russian Federation, Rostov-on-Don

Diana S. Uzdenova

Rostov State Medical University

Email: holmesamanda147@gmail.ru
ORCID iD: 0009-0003-2895-0382

student

Russian Federation, Rostov-on-Don

Elena V. Gantsgorn

Rostov State Medical University

Email: gantsgorn@inbox.ru
ORCID iD: 0000-0003-0627-8372
SPIN-code: 4797-6070

MD, Cand. Sci. (Med.), associate professor

Russian Federation, Rostov-on-Don

Oksana M. Kudelina

Rostov State Medical University

Email: kuomi81@mail.ru
ORCID iD: 0000-0003-3889-345X
SPIN-code: 2750-8743

MD, Cand. Sci. (Med.)

Russian Federation, Rostov-on-Don

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