PULMONARY TUBERCULOSIS WITH MULTIPLE DRAG-RESISTANT M. TUBERCULOSIS IN PATIENTS WITH DIABETES MELLITUS

Abstract


The aim of the study was to study the clinical manifestations and effectiveness of treatment of pulmonary tuberculosis with multidrug-resistant (MDR M. tuberculosis (MTB) in patients with different types of diabetes mellitus (DM). 66 patients with pulmonary tuberculosis combined with type 1 diabetes mellitus and 48 patients with pulmonary tuberculosis combined with type 2 diabetes were examined. It was found that in patients with type 1 DM, MDR tuberculosis was more often observed in men under 40 years of age, in the form of infiltrative pulmonary tuberculosis with the presence of destruction in lung tissue up to 2 cm in diameter with positive sputum and acute intoxication. In patients with type 2 DM, MDR tuberculosis was more often observed in men over the age of 40 in the form of fibrous-cavernous tuberculosis with the presence of destruction in lung tissue larger than 2 cm in diameter, with positive sputum and moderately severe intoxication. The effectiveness of treatment for negativation sputum in the compared groups did not differ significantly and amounted to 71,2% and 64,7%, respectively. However, to close the caverns in the lung, the treatment was more effective in patients with type 1 diabetes, which is probably due to the peculiarities of the tuberculosis process in this category of patients.

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About the authors

O. G Komissarova

Central Tuberculosis Research Institute; N.I. Pirogov Russian National Research Medical University

107564, Moscow, Russian Federation; 117997, Moscow, Russian Federation

Rizvan Yu.O. Abdullaev

Central Tuberculosis Research Institute

Email: rizvan0403@yandex.ru
107564, Moscow, Russian Federation
doctor of medical science, professor, leading researcher “Central Tuberculosis Research Institute”, 107564, Moscow, Russian Federation

S. V Aleshina

Central Tuberculosis Research Institute

107564, Moscow, Russian Federation

V. V Romanov

Central Tuberculosis Research Institute

107564, Moscow, Russian Federation

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