Rhinosinusitis in children with acute respiratory infection: quality of life and features of drug therapy

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Abstract

BACKGROUND: The relevance of the study is due to limited information on the impact of various forms of rhinosinusitis that have arisen against the background of acute respiratory infection on the quality of life of children and effective treatment methods.

AIM: To conduct a clinical assessment of the effect on the recovery time and quality of life in children with acute rhinosinusitis and exacerbation of polypous rhinosinusitis that occurred against the background of a respiratory infection, including antiviral drugs in complex treatment in the early stages.

MATERIALS AND METHODS: A simple controlled randomized comparative clinical trial was conducted, involving 74 children aged 15 to 18 years. The clinical efficacy and safety of the use of antiviral drugs in complex therapy, which are neuraminidase inhibitors on the 5th, 7th and 10th days of treatment, were evaluated in comparison with groups receiving pentanedioic acid imidazolylethanamide. The inclusion criterion was acute rhinosinusitis and exacerbation of chronic polypous rhinosinusitis against the background of acute respiratory infection. To establish the diagnosis, an examination of ENT organs, computed tomography of the nose and paranasal sinuses were performed, patients subjectively assessed clinical complaints and quality of life in the Russian version of the standard form of the SF-36 questionnaire.

RESULTS: Positive dynamics was noted in the early stages in the 2nd subgroup of the 1st group who took neuraminidase inhibitors in addition to complex therapy. Manifested by a decrease in the average score for VAS to 80.0%, difficulty in nasal breathing to 1.7 points on the 10th day of treatment, relative to those taking imidazolylethanamide pentanedioic acid, where there was a decrease in the average score for VAS by 22.4%, difficulty in nasal breathing to 2.54 points. A similar pattern was observed with nasal congestion, rhinorrhea, and quality of life indicators according to the SF-36 questionnaires.

CONCLUSION: Improvement of clinical symptoms and quality of life indicators at an earlier date in children with polypous rhinosinusitis and acute rhinosinusitis against the background of a previous respiratory infection with the inclusion of neuraminidase inhibitors in complex therapy confirmed higher efficacy.

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About the authors

Alexander A. Krivopalov

Saint Petersburg Research Institute of Ear, Throat, Nose and Speech; North-Western State Medical University named after I.I. Mechnikov

Email: krivopalov@list.ru
ORCID iD: 0000-0002-6047-4924
SPIN-code: 8135-9408

MD, Dr. Sci. (Medicine), associate professor

Russian Federation, Saint Petersburg; Saint Petersburg

Sergey V. Ryazantsev

North-Western State Medical University named after I.I. Mechnikov

Email: professor.ryazantsev@mail.ru
ORCID iD: 0000-0003-1710-3092
SPIN-code: 9902-7386

MD, Dr. Sci. (Medicine), professor

Russian Federation, Saint Petersburg

Musos Yu. Korkmazov

South Ural State Medical University

Author for correspondence.
Email: Korkmazov74@gmail.com
ORCID iD: 0000-0002-8642-0166
SPIN-code: 5592-9007

MD, Dr. Sci. (Medicine), professor

Russian Federation, Chelyabinsk

Arsen M. Korkmazov

South Ural State Medical University

Email: Korkmazov09@gmail.com
ORCID iD: 0000-0002-3981-9158
SPIN-code: 5456-8493

MD, Сand. Sci. (Medicine), associate professor

Russian Federation, Chelyabinsk

Maria A. Lengina

South Ural State Medical University

Email: Danilenko1910@mail.ru
ORCID iD: 0000-0002-8103-192X
SPIN-code: 9562-7956

MD, Сand. Sci. (Medicine), associate professor

Russian Federation, Chelyabinsk

Natalia V. Kornova

South Ural State Medical University

Email: versache-k@mail.ru
ORCID iD: 0000-0001-6077-2377
SPIN-code: 0953-7705

MD, Cand. Sci. (Medicine), associate professor

Russian Federation, Chelyabinsk

References

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Supplementary files

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2. Fig. 1. Difficulty of nasal breathing on the background of ongoing therapy according, points to VASH; * statistically significant differences from the corresponding indicators of the control group. The nonparametric Mann–Whitney criterion was used for calculations at a significance level р <0.05.

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3. Fig. 2. Dynamics of rhinorrhea reduction in patients on the background of ongoing therapy, points to VASH; * statistically significant differences from the corresponding indicators of the control group. The nonparametric Mann–Whitney criterion was used for calculations at a significance level р <0.05.

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4. Fig. 3. Assessment of the dynamics of nasal polyposis by staging according to Lund–Mackay; * statistically significant differences from the corresponding indicators of the control group. The nonparametric Mann–Whitney criterion was used for calculations at a significance level р <0.05.

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5. Fig. 4. The quality of life of group 1 patients before treatment and against the background of ongoing therapy; * statistically significant differences from the corresponding indicators of the control group. The nonparametric Mann–Whitney criterion was used for calculations at a significance level р <0.05. See text for designations.

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6. Fig. 5. The quality of life of group 2 patients before treatment and against the background of ongoing therapy; * statistically significant differences from the corresponding indicators of the control group. The nonparametric Mann–Whitney criterion was used for calculations at a significance level р <0.05. See text for designations.

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