Some aspects of pharmacological support with antidysrhythmic drugs

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A high level of morbidity and mortality from cardiovascular diseases remains prevalent in the Russian Federation, despite a decreasing trend that emerged in recent years. Rhythm and conduction disorders play an essential role in the thanatogenesis of cardiovascular pathology, which determines the medical and social significance of their pharmacotherapy. This is indicated by the stable demand for antidysrhythmic drugs from both the state and the population. This is evidenced by high levels of public procurements and retail sales of “drugs for the treatment of cardiovascular diseases,” since patients take this drug group for a long time and often permanently. Our marketing analysis of the antidysrhythmic drugs market used current open data from the State Register of Medicines and the State Register of Maximum Selling Prices and available analytical data. It showed that from 54.5% (metoprolol drugs) to 100% (procainamide drugs) of the market share is occupied by generic drugs made in Russia. The presented analysis confirms the assumption of a significant increase in the share of generic drugs in public procurements. This is associated with the implementation of the drug safety program for vital and essential drugs and the optimization of costs by the state. A priority of the state drug policy in Russia is to monitor the effectiveness and safety throughout its entire life cycle. Moreover, particular importance should be given to the issue of interchangeability, which is regulated by Federal Law No. 1360 dated September 5, 2020, “On the Procedure for Determining the Interchangeability of Medicines for Medical Use.” The annual increase in the share of generic domestic antidysrhythmic drugs on the market poses the problem of selecting the most efficient and safe approach to pharmacotherapy for practicing specialists. The solution may be to develop and implement open automated information systems for the safety profiles of the original and generic antidysrhythmic drugs.

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About the authors

Vladimir V. Archipov

Scientific Centre for Expert Evaluation of Medicinal Product

ORCID iD: 0000-0002-1441-3418

 MD, Dr. Sci. (Med.)

Russian Federation, 8/2 Petrovsky Boulevard, 127051, Moscow

Yuliya R. Bolsunovskaya

Scientific Centre for Expert Evaluation of Medicinal Product

Author for correspondence.
ORCID iD: 0000-0002-8721-0005
Russian Federation, 8/2 Petrovsky Boulevard, 127051, Moscow


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Supplementary files

Supplementary Files
1. Fig. 1. Holders of registration certificates for antidysrhythmic drugs (%).

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2. Fig. 2. Positions (1–20) of the drug “Concor” in the monthly schedule of pharmacy sales in 2018 and 2019.

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