A clinical case of the novel coronavirus (COVID-19) reinfection in a health care worker

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Abstract

The peculiarities of immune responses to a novel coronavirus infection (COVID-19) and the possibility of reinfection due to the variability of humoral immunity are currently under discussion. This article presents a case of COVID-19 reinfection in a health care worker.

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About the authors

Irina V. Kovtyukh

Federal State Budgetary Institution of Healthcare Central Clinical Hospital of the Russian Academy of Sciences

Author for correspondence.
Email: ivkovtuh@mail.ru
ORCID iD: 0000-0002-9176-1889
Russian Federation, 1A Litovsky Boulevard, 117593, Moscow

Gennady E. Gendlin

N.I. Pirogov Russian National Research Medical University

Email: rgmut2@mail.ru
ORCID iD: 0000-0002-7846-1611

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Igor G. Nikitin

N.I. Pirogov Russian National Research Medical University

Email: igor.nikitin.65@mail.ru
ORCID iD: 0000-0003-1699-0881

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Ekaterina V. Kabirova

City clinical hospital №24

Email: bazamarsa@mail.ru
Russian Federation, Mosсow

Olga Yu. Markina

City clinical hospital №24

Email: o.u@gmail.com
Russian Federation, Mosсow

References

  1. Roy S. COVID-19 Reinfection: Myth or Truth? SN Compr Clin Med. 2020:1–4. doi: 10.1007/s42399-020-00335-8
  2. Law SK, Leung AWN, Xu C. Is reinfection possible after recovery from COVID-19? Hong Kong Med J. 2020;26(3):264–265.
  3. Falahi S, Kenarkoohi A. COVID-19 reinfection: prolonged shedding or true reinfection? New Microbes New Infect. 2020;38:100812. doi: 10.1016/j.nmni.2020.100812
  4. Khoshkam Z, Aftabi Y, Stenvinkel P, et al. Recovery scenario and immunity in COVID-19 disease: A new strategy to predict the potential of reinfection. J Adv Res. 2021; 31:49-60. doi: 10.1016/J.jare.2020.12.013
  5. Kang H, Wang Y, Tong Z, Liu X. Retest positive for SARS-CoV-2 RNA of “recovered” patients with COVID-19: Persistence, sampling issues, or re-infection? J Med Virol. 2020;92(11):2263–2265.
  6. SeyedAlinaghi S, Oliaei S, Kianzad S, et al. Reinfection risk of novel coronavirus (COVID-19): A systematic review of current evidence. World J Virol. 2020;9(5):79–90.
  7. Tao W, Wang X, Zhang G, et al. Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection. Protein Cell. 2021;12(3):230–235.
  8. Wu F, Zhang W, Zhang L, et al. Discontinuation of antiviral drugs may be the reason for recovered COVID-19 patients testing positive again. Br J Hosp Med (Lond). 2020;81(4):1–2.
  9. Kang H, Wang Y, Tong Z, Liu X. Retest positive for SARS-CoV-2 RNA of “recovered” patients with COVID-19: Persistence, sampling issues, or re-infection? J Med Virol. 2020;92(11):2263–2265.
  10. Piri SM, Edalatfar M, Shool S, et al. A systematic review on the recurrence of SARS-CoV-2 virus: frequency, risk factors, and possible explanations. Infect Dis (Lond). 2021;(Jan 28):1–10. doi: 10.1080/23744235.2020.1871066
  11. Alizargar J. Risk of reactivation or reinfection of novel coronavirus (COVID-19). J Formos Med Assoc. 2020;119(6):1123. doi: 10.1016/j.jfma.2020.04.013
  12. Gousseff M, Penot P, Gallay L, et al. Clinical recurrences of COVID-19 symptoms after recovery: Viral relapse, reinfection or inflammatory rebound? J Infect. 2020;81(5):816–846.
  13. Arafkas M, Khosrawipour T, Kocbach P, et al. Current meta-analysis does not support the possibility of COVID-19 reinfections. J Med Virol. 2021;93(3):1599–1604.
  14. Madan M, Kunal S. COVID-19 reinfection or relapse: an intriguing dilemma. Clin Rheumatol. 2020;39(11):3189. doi: 10.1007/s10067-020-05427-3
  15. He F, Luo Q, Lei M, et al. Successful recovery of recurrence of positive SARS-CoV-2 RNA in COVID-19 patient with systemic lupus erythematosus: a case report and review. Clin Rheumatol. 2020;39(9):2803–2810.
  16. Jabbari P, Rezaei N. With Risk of Reinfection, Is COVID-19 Here to Stay? Disaster Med Public Health Prep. 2020;14(4):e33. doi: 10.1017/dmp.2020.274
  17. Parry J. Covid-19: Hong Kong scientists report first confirmed case of reinfection. BMJ. 2020;370:m3340. doi: 10.1136/bmj.m3340
  18. West J, Everden S, Nikitas N. A case of COVID-19 reinfection in the UK. Clin Med (Lond). 2021;21(1):e52-e53. doi: 10.7861/clinmed.2020-0912
  19. Iwasaki A. What reinfections mean for COVID-19. Lancet Infect Dis. 2021;21(1):3–5.
  20. Nachmias V, Fusman R, Mann S, Koren G. The first case of documented Covid-19 reinfection in Israel. IDCases. 2020;22:e00970. doi: 10.1016/j.idcr.2020.e00970
  21. Duggan NM, Ludy SM, Shannon BC, et al. Is novel coronavirus 2019 reinfection possible? Interpreting dynamic SARS-CoV-2 test results. Am J Emerg Med. 2021;39:256 e251-256 e253. doi: 10.1016/j.ajem.2020.06.079
  22. Bonifacio LP, Pereira APS, Araujo D, et al. Are SARS-CoV-2 reinfection and Covid-19 recurrence possible? a case report from Brazil. Rev Soc Bras Med Trop. 2020;53:e20200619. doi: 10.1590/0037-8682-0619-2020
  23. Pal R, Banerjee M. Are people with uncontrolled diabetes mellitus at high risk of reinfections with COVID-19? Prim Care Diabetes. 2021;15(1):18–20.
  24. Torres DA, Ribeiro L, Riello A, et al. Reinfection of COVID-19 after 3 months with a distinct and more aggressive clinical presentation: Case report. J Med Virol. 2021;93(4):1857–1859.
  25. Azam M, Sulistiana R, Ratnawati M, et al. Recurrent SARS-CoV-2 RNA positivity after COVID-19: a systematic review and meta-analysis. Sci Rep. 2020;10(1):20692. doi: 10.1038/s41598-020-77739-y

Supplementary files

Supplementary Files
Action
1. Fig. 1. Thoracic computed tomography of patient K. in the first episode of the disease.

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2. Fig. 2. Dynamics of SARS-CoV-2 (nCoV IgG) antibodies after the first episode of the disease.

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