Email this article Bronchial asthma and obesity: features of systemic inflammation depending on the time of onset of asthma symptoms
- Authors: Anikin D.1,2, Solovieva I.A.1,2, Demko I.V.1,2, Sobko E.A.1,2, Gordeeva N.V.1,2, Kraposhina A.Y.1,2
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Affiliations:
- Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
- Krasnoyarsk Clinical Regional Hospital
- Section: Original Research Articles
- Submitted: 13.12.2024
- Accepted: 22.08.2025
- Published: 28.09.2025
- URL: https://medjrf.com/0869-2106/article/view/642919
- DOI: https://doi.org/10.17816/medjrf642919
- ID: 642919
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Open Access
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Abstract
BACKGROUND: Bronchial asthma (BA) is a complex heterogeneous polyetiological chronic disease. Pathophysiological mechanisms of interaction between bronchial asthma and obesity are of interest.
AIMS: Evaluation of cytokine profile features in patients with bronchial asthma with obesity, depending on the time of asthma onset.
MATERIALS AND METHODS: During the study, 180 people were examined: 150 patients with BA of varying severity, who were divided into groups based on BMI: group 1 included patients with BA with BMI from 18.5 to 25 kg/m2 (n=52), group 2 included patients with BA with BMI from 30 to 35 kg/m2 (n=98), the control group consisted of 30 people. Further, patients with asthma and obesity were divided depending on the time of asthma onset into the «Obesity + BA» group and the «BA + Obesity» group with asthma history of about 10 years. During the study, the severity of bronchial asthma was assessed using AST and ACQ tests, spirography with a bronchodilator test was performed, venous blood was collected to determine the cytokine profile (tumor necrosis factor-α; interleukins-2, 4, 6, 8, 10, 17; interferon-INF-γ), markers of systemic inflammation (C-reactive protein, fibrinogen).
RESULTS: The phenotype of bronchial asthma in combination with obesity was characterized by a more severe course, worse disease control, while in the «Obesity + BA» group, more severe bronchial patency disorders were recorded. When analyzing the cytokine profile in the study groups, a significant imbalance of proinflammatory and anti-inflammatory cytokines was noted, which was most pronounced in the «Obesity + BA» group. According to the data obtained, it was noted that it is important to determine the ratio index of various cytokines with opposite activity (IL-2 / IL-4, IL-2 / IL-10, IL-8 / IL-10, IL-6 / IL-10, TNF-α / IL-10) to determine the severity of the inflammatory process and further treatment tactics for patients.
CONCLUSIONS: Obesity leads to the formation and maintenance of systemic inflammation in the body and is a negative aggravating factor in the development and progression of BA.
Full Text
About the authors
Dmitriy Anikin
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
Email: anikin27111994@mail.ru
ORCID iD: 0000-0002-1598-436X
assistant of Department of Hospital Therapy and Immunology with a Postgraduate Education Course; Pulmonologist of Department of Pulmonology
Russian Federation, KrasnoyarskIrina A. Solovieva
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
Email: acad-prorector@krasgmu.ru
ORCID iD: 0000-0002-1999-9534
Dr. med. habil., associate professor, professor of the Department of hospital therapy and immunology with a postgraduate education course
KrasnoyarskIrina V. Demko
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
Email: demko64@mail.ru
ORCID iD: 0000-0001-8982-5292
MD, professor of Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia, head of the pulmonary and allergological center of Regional clinical hospital (Krasnoyarsk)
Russian Federation, KrasnoyarskElena A. Sobko
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
Email: sobko29@mail.ru
ORCID iD: 0000-0002-9377-5213
MD, professor of Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia, head of the Department of allergology of Regional clinical hospital (Krasnoyarsk)
Russian Federation, KrasnoyarskNatalya V. Gordeeva
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
Email: natagorday@yandex.ru
ORCID iD: 0000-0002-0586-8349
PhD in Medicine, associate professor of the Department of hospital therapy and immunology with a postgraduate education course
KrasnoyarskAngelina Yu. Kraposhina
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
Author for correspondence.
Email: angelina-maria@inbox.ru
ORCID iD: 0000-0001-6896-877X
MD, PhD (Med.), Associate Professor of Department of Hospital Therapy and Immunology with a Postgraduate Education Course, Pulmonologist
Russian Federation, KrasnoyarskReferences
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