Влияние антидепрессантов на массу тела: механизмы, клинические последствия и стратегии контроля
- Авторы: Байрамалов В.А., Даутова В.А., Бахарева М.Д., Завгородняя-Марьямс А.С., Алыева Л.Р., Исмиханов М.М., Газизова А.И., Зорина Н.А., Малинина Я.А., Ведерникова В.В., Мельник Р.К., Маляр Э.И., Шамсутдинова А.Р., Кичева Б.М., Гулиева Н.Б.
- Раздел: Обзоры
- Статья получена: 01.03.2025
- Статья одобрена: 09.04.2025
- URL: https://medjrf.com/0869-2106/article/view/675281
- DOI: https://doi.org/10.17816/medjrf675281
- ID: 675281
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Аннотация
Депрессия и ожирение являются распространёнными заболеваниями, оказывающими значительное влияние на качество жизни и общественное здоровье. В последние десятилетия отмечается рост распространённости депрессии, сопровождающийся увеличением потребления антидепрессантов. Однако, несмотря на доказанную эффективность антидепрессантов, одним из их значительных побочных эффектов является увеличение массы тела, что может усугублять течение ожирения и метаболических нарушений у пациентов. В настоящем обзоре рассматриваются механизмы, лежащие в основе влияния антидепрессантов на массу тела, включая нейромедиаторные, воспалительные и генетические факторы. Анализируются различия в метаболическом профиле различных классов антидепрессантов, с акцентом на селективные ингибиторы обратного захвата серотонина, ингибиторы обратного захвата серотонина и норадреналина, норадренергические и специфические серотонинергические антидепрессанты, трициклические антидепрессанты и ингибиторы моноаминоксидазы. Рассматриваются возможные стратегии контроля массы тела, включая модификацию фармакотерапии, поведенческие вмешательства, фармакологическую коррекцию и бариатрическую хирургию. Подчёркивается необходимость персонализированного подхода при выборе антидепрессантов и разработки интегрированных стратегий ведения пациентов с депрессией и ожирением.
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Об авторах
Вячеслав Аркадьевич Байрамалов
Автор, ответственный за переписку.
Email: chirach726@gmail.com
ORCID iD: 0009-0003-5626-1752
Россия
Вилена Альфредовна Даутова
Email: vilench9@gmail.com
ORCID iD: 0009-0005-7211-4263
Мария Денисовна Бахарева
Email: bakha.mashereva@gmail.com
ORCID iD: 0009-0005-3197-4769
Александра Сергеевна Завгородняя-Марьямс
Email: zavgar_m7686@mail.ru
ORCID iD: 0009-0005-4413-4750
Лала Рахмановна Алыева
Email: lala.alyeva@bk.ru
ORCID iD: 0009-0000-5745-0764
Мурад Мизамиевич Исмиханов
Email: ismikhanov.murad@bk.ru
ORCID iD: 0009-0007-2887-290X
Алина Ильгизовна Газизова
Email: G.alina17@icloud.com
ORCID iD: 0009-0006-2427-9546
Нелли Александровна Зорина
Email: zorinanelly@mail.ru
ORCID iD: 0009-0005-4017-1087
Яна Андреевна Малинина
Email: yanamalinin4@yandex.ru
ORCID iD: 0009-0004-3991-4165
Владислава Владиславовна Ведерникова
Email: vladavedernicova@gmail.com
ORCID iD: 0009-0008-4148-1310
Роман Константинович Мельник
Email: romelnyk3@gmail.com
ORCID iD: 0009-0008-3319-6405
Элина Игоревна Маляр
Email: elinamalyar@yandex.ru
ORCID iD: 0009-0009-2181-092X
Айгиза Римовна Шамсутдинова
Email: rimovna49@gmail.com
ORCID iD: 0009-0005-9849-2764
Бэлла Мухамедовна Кичева
Email: bellkicheva@mail.ru
ORCID iD: 0009-0000-0922-2521
Нармин Балазаир кызы Гулиева
Email: narmin.gulieva28@mail.ru
ORCID iD: 0009-0009-1394-942X
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