电邮这篇文章 The neuroprotective properties of nerve growth factor adsorbed on poly(butyl) cyanoacrylate nanoparticles during experimental simulation of hemorrhagic stroke
- 作者: Khosravani M1, Rezayat SM1, Sarkar S1, Alyautdin RN1, Khosravani M1, Rezaiat SM1, Sarkar S1, Alyautdin RN1
-
隶属关系:
- 期: 卷 17, 编号 2 (2011)
- 页面: 27-30
- 栏目: Articles
- ##submission.dateSubmitted##: 21.07.2020
- ##submission.datePublished##: 15.04.2011
- URL: https://medjrf.com/0869-2106/article/view/37917
- DOI: https://doi.org/10.17816/rmj37917
- ID: 37917
如何引用文章
全文:
详细
The neuroprotective activity of nerve growth factor adsorbed on poly(butyl) cyanoacrylate nanoparticles was evaluated in rats with intracerebral posttraumatic hematoma - hemorrhagic stroke (HS) induced by brain tissue destruction in the internal capsular area. When re-administered intraperitoneally for 3 days, nerve growth factor (5 μ) adsorbed on poly(butyl) cyanoacrylate nanoparticles coated with polysorbate-80 attenuated HS-induced neurological deficit and coordination disorders, optimized rat orientative-exploratory behavior and motor activity, improved reproduction of a conditioned passive avoidance response, prevented the death of the animals, and diminished their weight loss. The findings suggest the potential neuroprotective effect of nerve growth factor (5 μ) adsorbed on polysorbate-80-coated poly(butyl) cyanoacrylate nanoparticles.
参考
- Аляутдин Р. Н. и др. // Вестн. НИИ молекул. мед. - 2003. - № 3. - С. 11-29.
- Гарибова Т. Л. // Эксперим. и клин. фармакол. - 2003. - Т. 66, № 3. - С. 13-16.
- Alyautdin R. N., Kreuter J., Ramge P. et al. // Pharm. Res. - 2003. - Vol. 20. - P. 409-416.
- Dafang Wu. // NeuroRx. - 2005. - Vol. 2, N 1. - P. 120- 128.
- Myron D. Ginsberg // Neuropharmacology. - 2008. - Vol. 55, N 3. - P. 363-389.
补充文件
