Участие тандема «тучная клетка – нейрон» в регуляции работы сердца при сердечно-сосудистых патологиях

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Аннотация

Данный обзор посвящен изложению новых данных об участии тучных клеток (ТК) в регуляции работы сердца при развитии некоторых сердечно-сосудистых патологий. В норме содержание ТК в сердце невелико по сравнению с их количеством в барьерных тканях. Они отвечают за гомеостаз сердечной ткани и обеспечение взаимодействия органа с нервной и эндокринной системами на протяжении всей жизни организма.

Патологические процессы в сердце сопровождаются развитием реакции воспаления, в формировании всех этапов которой значительная роль принадлежит ТК. На фоне развития инфаркта миокарда, фибротического поражения сердца и атеросклероза сосудов число ТК существенно возрастает. Их вклад в патогенез заболевания неоднозначен, поскольку с одной стороны направлен на адаптацию ткани к повреждению, а с другой – лавинообразный синтез и высвобождение медиаторов из активированных ТК усугубляет течение процесса. В результате ТК меняют свой секреторный профиль, вмешиваются в реализацию функций сердца на фоне воспаления, но вместе с тем и модулируют афферентный поток информации от сердца и эфферентные влияния нервной системы. Слаженная работа системы теряет свою устойчивость, что может привести к тяжелым последствиям для жизнедеятельности всего организма.

Анализ современного состояния проблемы свидетельствует, что от функционального состояния ТК, их сложного взаимодействия с нервной системой зависит деятельность сердца как в норме, так и, особенно, на фоне развития патологических процессов.

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М. П. Морозова

Российский национальный исследовательский медицинский университет им. Н.И. Пирогова

Автор, ответственный за переписку.
Email: mormasha@gmail.com
Россия, Москва

А. Д. Куренкова

Институт регенеративной медицины, Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский университет)

Email: mormasha@gmail.com
Россия, Москва

Б. А. Умарова

Московский государственный университет им. М.В. Ломоносова

Email: mormasha@gmail.com
Россия, Москва

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2. Рис. 1. Взаимодействие кардиальных тучных клеток и нейронов. Условные обозначения: сплошными линиями указаны сигнальные соединения ТК, действующие на нейроны, а пунктирными – нейромедиаторы нейронов, активные в отношении кардиальных ТК.

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