Protective Roles and Therapeutic Effects of Gallic Acid in the Treatment of Cardiovascular Diseases: Current Trends and Future Directions


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Cardiovascular diseases (CVDs) are serious life-threatening illnesses and significant problematic issues for public health having a heavy economic burden on all society worldwide. The high incidence of these diseases as well as high mortality rates make them the leading causes of death and disability. Therefore, finding novel and more effective therapeutic methods is urgently required. Gallic acid, an herbal medicine with numerous biological properties, has been utilized in the treatment of various diseases for thousands of years. It has been demonstrated that gallic acid possesses pharmacological potential in regulating several molecular and cellular processes such as apoptosis and autophagy. Moreover, gallic acid has been investigated in the treatment of CVDs both in vivo and in vitro. Herein, we aimed to review the available evidence on the therapeutic application of gallic acid for CVDs including myocardial ischemia-reperfusion injury and infarction, drug-induced cardiotoxicity, hypertension, cardiac fibrosis, and heart failure, with a focus on underlying mechanisms.

Об авторах

Zahra Momeni

, Kurdistan University of Medical Sciences

Email: info@benthamscience.net

Sepideh Danesh

Research Hub Institute, Tehran University of Medical Sciences

Email: info@benthamscience.net

Mahsa Ahmadpour

Research Hub Institute,, Tehran University of Medical Sciences

Email: info@benthamscience.net

Reza Eshraghi

School of Medicine, Kashan University of Medical Sciences

Email: info@benthamscience.net

Tahereh Farkhondeh

Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences

Email: info@benthamscience.net

Mohammad Pourhanifeh

Research Hub Institute, Tehran University of Medical Sciences

Автор, ответственный за переписку.
Email: info@benthamscience.net

Saeed Samarghandian

, University of Neyshabur Healthy Ageing Research Centre, Neyshabur University of Medical Sciences

Автор, ответственный за переписку.
Email: info@benthamscience.net

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