Biological Therapies for Pediatric Atopic Dermatitis - A Review


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Atopic dermatitis (AD) is the most frequent chronic-recurrent inflammatory skin disease in the pediatric age. It has a complex and multifactorial pathogenesis: the two key actors are im- paired skin barrier function and immune system dysregulation, which represent the main targets of AD therapy. Monoclonal antibodies have revolutionized the management of moderate-to-severe AD, by selective inhibition of key cytokines in the pathogenetic process. For this reason, there is great interest in exploring AD pathogenetic mechanisms to develop new therapeutic strategies. This review aims to summarize the most recent scientific evidence on available and future biologi- cal therapies for the treatment of pediatric AD, emphasizing the molecular mechanisms underlying their action.

Sobre autores

Giulia Milano

Division of Pediatrics, Department of Health Sciences,, Università del Piemonte Orientale

Email: info@benthamscience.net

Stefano Forestieri

School of Pediatrics, University of Cagliari

Email: info@benthamscience.net

Micol Tedeschi

Pediatric Unit, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences,, University of Pavia

Email: info@benthamscience.net

Amelia Licari

Pediatric Unit, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia

Autor responsável pela correspondência
Email: info@benthamscience.net

Valeria Brazzelli

Department of Clinical-Surgical, Diagnostic and Pediatric Science, University of Pavia

Email: info@benthamscience.net

Gian Marseglia

Pediatric Unit, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia

Email: info@benthamscience.net

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