Assessment of the efficiency of prevention of chronic fluorine intoxication with Rhodiola Rosea L. adaptogen

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Introduction. Fluorine and its compounds are industrial pollutants that cause the development of chronic fluorine intoxication (CFI) during long-term intake. It has been shown that in CFI there are disturbances in metabolic processes and morphological changes in various organs. Therefore, the search for organ protective prevention and correction of damage caused by CFI remains relevant in occupational health and medicine. The perspective direction is the assessment of the possibility of prevention and correction of CFI related disorders by means of the remedies of plant origin possessing adaptogenic action, one of which is Rhodiola Rosea L.

The objective of the research. To evaluate the effectiveness of organ protective prevention of chronic fluoride intoxication with an adaptogenic drug-containing Rhodiola Rosea L in the experiment conditions

Material and methods. The work was carried out on 45 white male rats weighing 200-250 g. Animals were divided into groups of 15 animals: control rats; rats with chronic exposure to sodium fluoride (NaF) for 12 weeks; rats who received NaF solution while administering of Rhodiola Rosea L. extract. Determination of biochemical indices of metabolism in blood serum and histologic studies of the organs (liver and kidneys) were performed.

Results. The use of an adaptogenic drug-containing Rhodiola Rosea L. was shown to be effective in preventing the disorders caused by chronic exposure to fluorine compounds, since it normalizes oxidative metabolism in tissues, reduces the manifestation of degenerative, dystrophic and necrotic changes in the liver and kidneys, restores the synthetic and detoxication functions of the liver, and also preserves the homeostatic function of the kidneys.

Conclusion. The use of an adaptogenic drug-containing Rhodiola Rosea L. for the prevention of damage caused by the chronic effects of fluorine compounds on the body is effective.

作者简介

N. Mikhailova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk Institute (Branch Campus) of Kemerovo State University

编辑信件的主要联系方式.
Email: noemail@neicon.ru
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Anna Zhukova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk Institute (Branch Campus) of Kemerovo State University

Email: nyura_g@mail.ru
ORCID iD: 0000-0002-4797-7842

MD, Ph.D., DSci., head of the Laboratory of molecular-genetic and experimental researches, Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation.

e-mail: nyura_g@mail.ru

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L. Gorokhova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk Institute (Branch Campus) of Kemerovo State University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0545-631X
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M. Bugaeva

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: noemail@neicon.ru
ORCID iD: 0000-0003-3692-2616
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T. Yadykina

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: noemail@neicon.ru
ORCID iD: 0000-0001-7008-1035
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A. Kiseleva

Novokuznetsk Clinical Oncology Dispensary

Email: noemail@neicon.ru
俄罗斯联邦

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