Mechanisms of the antimicrobial action of fatty acids (review)

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Among the diverse biological activities of fatty acids, the ability to kill or inhibit the growth of microorganisms can be distinguished. Despite the fact that the antibacterial mechanisms of fatty acids are not fully understood, the most common target of action is the cell membrane, where FAs mediate an increase in permeability and subsequent cell lysis, lead to disruption of the electron transport chain, uncoupling of oxidative phosphorylation, and inhibit enzymatic activity and nutrient intake. In addition to acting on cell membranes, FAs have the ability to disrupt the metabolic processes of microorganisms, inhibit DNA/RNA replication, and affect the expression of virulence genes. In addition, non-traditional mechanisms of the antimicrobial action of FAs are currently being described, such as inhibition of horizontal gene transfer, quorum sensing, and disruption of the efflux pump. The variety of antimicrobial mechanisms and a wide range of their activity determine the high biotechnological potential of fatty acids and make further studies of the mechanisms of action on biological systems relevant.

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Sobre autores

E. Obukhova

Petrozavodsk State University

Autor responsável pela correspondência
Email: Obyhova_elena@mail.ru
Rússia, Petrozavodsk, 185003

S. Murzina

Institute of Biology of the Karelian Research Center of the Russian Academy of Sciences

Email: murzina.svetlana@gmail.com
Rússia, Petrozavodsk, 185910

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