New pharmacological effects of caripazim

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The effects of a proteolytic enzyme found in papaya milk juice (caripazim) on the rate of lymphatic drainage of tissues and the pharmacokinetics of cefotaxime were studied in experiments on rabbits and mice. During the study, caripazim was administered to experimental animals, and the rate of removal of Evans blue from the mesentery of mice, as well as the concentration of cefotaxime over time in the blood plasma of rabbits and the blood plasma, intestinal tissues, and livers of mice, after 1.5 and 24 h of antibiotic administration following injection of caripazim, were determined. Thus, the lymphostimulatory properties of caripazim were revealed. Its preliminary administration increased the concentration of cefotaxime in the blood plasma of rabbits in comparison with single administration of an antibiotic at all points of the study (1.5, 3, 4.5, 6, 8, 12, and 24 h). This coincides with the data from the study of the level of antibiotic in the blood plasma of mice. Administration of cefotaxime after injection of caripazim leads to an increase in its content in the intestinal tissue, after both 1.5 and 24 h, but does not affect at the accumulation of the antibiotic in the liver. The concentration ratio «liver tissue / blood» in mice in the main group was significantly lower than that in the control group, both 1.5 and 24 h into the experiment, which indirectly indicates a decrease in hepatic antibiotic extraction. The data obtained indicates that caripazim has the properties of an endolymphatic conductor.

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German V. Kukushkin

N.I.Pirogov Russian National Research Medical University

Author for correspondence.
ORCID iD: 0000-0002-5845-588X

MD, PhD, Professor

Russian Federation, 117997, Moscow

Marina V. Zhuravleva

Scientific Centre for Expert Evaluation of Medicinal Products; I.M.Sechenov First Moscow State Medical University (Sechenovsky University)

ORCID iD: 0000-0002-9198-8661

MD, PhD, DSc, Professor

Russian Federation, 127051, Moscow; 119991, Moscow

Lyudmila P. Sviridkina

Hunninen management compani

ORCID iD: 0000-0002-4537-7456

MD, PhD, DSc, Professor

Russian Federation, 119049, Moscow

Dmitry E. Yurov

N.I.Pirogov Russian National Research Medical University

ORCID iD: 0000-0003-0178-8736


Russian Federation, 117997, Moscow


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