New pharmacological effects of caripazim

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Abstract

The effects of a proteolytic enzyme found in papaya milk juice (caripazim) on the rate of lymphatic drainage of tissues and the pharmacokinetics of cefotaxime were studied in experiments on rabbits and mice. During the study, caripazim was administered to experimental animals, and the rate of removal of Evans blue from the mesentery of mice, as well as the concentration of cefotaxime over time in the blood plasma of rabbits and the blood plasma, intestinal tissues, and livers of mice, after 1.5 and 24 h of antibiotic administration following injection of caripazim, were determined. Thus, the lymphostimulatory properties of caripazim were revealed. Its preliminary administration increased the concentration of cefotaxime in the blood plasma of rabbits in comparison with single administration of an antibiotic at all points of the study (1.5, 3, 4.5, 6, 8, 12, and 24 h). This coincides with the data from the study of the level of antibiotic in the blood plasma of mice. Administration of cefotaxime after injection of caripazim leads to an increase in its content in the intestinal tissue, after both 1.5 and 24 h, but does not affect at the accumulation of the antibiotic in the liver. The concentration ratio «liver tissue / blood» in mice in the main group was significantly lower than that in the control group, both 1.5 and 24 h into the experiment, which indirectly indicates a decrease in hepatic antibiotic extraction. The data obtained indicates that caripazim has the properties of an endolymphatic conductor.

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About the authors

German V. Kukushkin

N.I.Pirogov Russian National Research Medical University

Author for correspondence.
Email: exampl@mail.ru
ORCID iD: 0000-0002-5845-588X

MD, PhD, Professor

Russian Federation, 117997, Moscow

Marina V. Zhuravleva

Scientific Centre for Expert Evaluation of Medicinal Products; I.M.Sechenov First Moscow State Medical University (Sechenovsky University)

Email: exampl@mail.ru
ORCID iD: 0000-0002-9198-8661

MD, PhD, DSc, Professor

Russian Federation, 127051, Moscow; 119991, Moscow

Lyudmila P. Sviridkina

Hunninen management compani

Email: exampl@mail.ru
ORCID iD: 0000-0002-4537-7456

MD, PhD, DSc, Professor

Russian Federation, 119049, Moscow

Dmitry E. Yurov

N.I.Pirogov Russian National Research Medical University

Email: exampl@mail.ru
ORCID iD: 0000-0003-0178-8736

MD, PhD

Russian Federation, 117997, Moscow

References

  1. Package insert for the medicine caripazim [Instruktsiya po primeneniyu preparata karipazim]. Available at: http://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=ecdf0662-d2c2-4f9f-ad90-98bf4506abcf&t= (accessed 23 June 2019) (in Russian)
  2. Penjiyev A.M., Abdullaev A. Scientific review: efficiency of proteolytic enzymes of papaya in medical practice. Nauka. Mysl’. 2016; 6(7-1): 228-51. (in Russian)
  3. Milind P., Gurditta. Basketful benefits of papaya. Int Res J Pharm. 2011; 2(7): 6-12.
  4. Mahmood A., Sidik K., Salmah I. Wound healing activity of Carica papaya L. aqueous extract in rats. Int J Mol Med Adv Sci. 2005; 1(4): 398-401.
  5. Owoyele B.V., Adebukola O.M., Funmilayo A.A., Soladoye A.O. Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharmacology. 2008; 16(4): 168-73. doi: 10.1007/s10787-008-7008-0.
  6. Doughari J.H., Elmahmood A.M., Manzara S. Studies on the antibacterial activity of root extracts of Carica papaya L. Afr J Microbiol Res. 2007; 1(3): 37-41.
  7. Nwinyi O.C., Abikoye B.A. Antifungal effects of pawpaw seeds extracts and papain on post harvest Carica papaya L. fruit rot. Afr J Agric Res. 2010; 5(12): 1531-5.
  8. Sarker S.K., Begum N., Mondal D., Siddique Md.A., Rashid M.A. In vitro study of antiamoebic effect of methanolic extract of mature seeds of Carica papaya on trophozoites of Entamoeba histolytica. Bangladesh J Pharmacol. 2010; 5(1): 45-7. doi: 10.3329/bjp.v5i1.5003.
  9. Ahmad N., Fazal H., Ayaz M., Abbasi B.H., Mohammad I., Fazal L. Dengue fever treatment with Carica papaya leaves extracts. Asian Pac J Trop Biomed. 2011; 1(4): 330–3. doi: 10.1016/S2221-1691(11)60055-5.
  10. Adeneye A.A., Olagunju J.A. Preliminary hypoglycemic and hypolipidemic activities of aqueous seed extract of Carica papaya Linn. in Wistar rats. Biol Med (Aligarh). 2009; 1(1): 1–10.
  11. Srikanth G., Manohar Babu S., Kavitha C.H.N., Bhanoji Rao M.E., Vyaykumar N., Pradeep C.H. Studies on in-vitro antioxidant activities of Carica papaya aqueous leaf extract. Res J Pharm Biol Chem Sci. 2010; 1(2): 59–65.
  12. Koffi N., Marie-Solange T., Emma A.A., Noel Z.G. Ethnobotanical study of plants used to reat arterial hypertension in traditional medicine, by abbey and Krobou population of Agboville (Cote d’ivoire). Eur J Sci Res. 2009; 35(1): 85–98.
  13. Wright C.I., Van-Buren L., Kroner C.I., Koning M.M. Herbal medicines as diuretics: a review of the scientific evidence. J Ethnopharmacol. 2007; 114(1): 1-31. doi: 10.1016/j.jep.2007.07.023.
  14. Olagunju J.A., Adeneye A.A., Fagbohunka B.S., Bisuga N.A. Nephroprotective activities of the aqueous seed extract of Carica papaya Linn. in carbon tetrachloride induced renal injured Wistar rats: a dose- and time-dependent study. Biol Med (Aligarh). 2009; 1(1): 11–9.
  15. Otsuki N., Dang N.H., Kumagai E., Kondo A., Iwata S., Morimoto C. Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol. 2010; 127(3): 760-7. doi: 10.1016/j.jep.2009.11.024.
  16. Kutuzov I.A., Naydin V.L., Novikov Yu.O. Caripazim electrophoresis and manual therapy in the complex treatment of lumbosacral radicular syndromes. Manual’naya terapiya. 2002; (4): 57-8. (in Russian)
  17. Abdygulova I.B., Abitova G.K., Alymkulov R.D. Caripazim-electrophoresis in complex ire aim ent of the lumbar intervertebral disks hernia. Zdravookhranenie Kyrgyzstana. 2006; (2): 109–11. (in Russian)
  18. Beidik O.V., Stepukhovich C.V., Nemalaev S.A., Antonova T.N., Sakkala X.M.F., Borodulin V.B. Experience of administering proteolytic enzymes in treatment of degenerative dystrophic disorders of the locomotor system. Vestnik Volgogradskogo gosudarstvennogo meditsinskogo universiteta. 2007; (2): 50-3. (in Russian)
  19. Margania T.Kh., Abshilava D.S., Tsiskaridze A.R. The effectiveness of the drug Karipazim for discogenic radiculopathy of the lower back: the results of a blinded placebo control study. Líki Ukraí̈ni. 2009; (9): 122-6. (in Russian)
  20. Pasieshvili L.M., Bobro L.N. The experience of the drug papainus using in the complex treatment of patients with osteoarthrosis and comorbid gastropathology. Krymskiy terapevticheskiy zhurnal. 2012; (1): 83-7. (in Russian)
  21. Beidick O.V., Antonova T.N., Stepoukhovich S.P., Sakkalla Kh., Nemaliayev S.A., Mandrov D.V. The experience of Caripazim preparation use in treatment of the locomotor system degenerative diseases. Geniy ortopedii. 2007; (2): 76-8. (in Russian)
  22. Volchegorskiy I.A., Dolgushin I.I., Kolesnikov O.L., Tseylikman V.E. Experimental modeling and laboratory assessment of adaptive body reactions. [Eksperimental’noe modelirovanie i laboratornaya otsenka adaptivnykh reaktsiy organizma]. Chelyabinsk: Izdatel’stvo Chelyabinskogo gosudarstvennogo pedagogicheskogo universiteta; 2000. (in Russian)

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