Pharmacoepidemiological analysis of the consumption of antibacterial drugs for the treatment of patients with nosocomial infections associated with previous hospitalization in multidisciplinary hospitals in the Tomsk region
- Authors: Perfileva D.Y.1, Miroshnichenko A.G.2, Perfilev V.Y.1, Kulikov E.S.1, Boykov V.A.1, Nesterovich S.V.1, Zima A.P.1
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Affiliations:
- Siberian State Medical University
- South Ural State Medical University
- Issue: Vol 29, No 4 (2023)
- Pages: 265-276
- Section: Original Research Articles
- URL: https://medjrf.com/0869-2106/article/view/408572
- DOI: https://doi.org/10.17816/medjrf408572
- ID: 408572
Cite item
Abstract
BACKGROUND: Healthcare-associated infections (HAIs) are one of the common complications associated with patients’ stay in a medical organization. An urgent practical problem is the choice of antibiotic therapy for the treatment of patients with nosocomial infections because these infections are caused by antibiotic-resistant strains. HAIs associated with previous hospitalization (HAPH) manifest in patients after discharge from the hospital, and their risk of isolating resistant strains often remains unrecognized by specialists. Thus, more studies are required to examine the structure of HAPH pathogens and patterns of consumption of antibacterial drugs for the treatment of HAPH to further determine antibiotic therapy in these patients.
AIMS: To analyze the use of antibiotic therapy for the treatment of HAPH with known etiological agents and the level of antibiotic resistance.
MATERIALS AND METHODS: The study analyzed the results of a multicenter descriptive retrospective study based on the Clinics Siberian State Medical University and the State Clinical Hospital No. B.I. Alperovich (Tomsk). A total of 108 HAPH cases were examined according to the medical records of inpatients (Form 003/y). For pharmacoepidemiological analysis, the anatomical therapeutic chemical/defined daily dose (DDD) methodology was used, and antibiotic intake was assessed using the number of established daily doses. The etiological structure of HSV microorganisms was evaluated using the AMRcloud online platform. Quantitative and qualitative indicators were presented as shares (%) and absolute numbers.
RESULTS: In total, 116 isolates from patients with HAPH were assessed. Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli were the dominant pathogens causing HAPH in the overall distribution of pathogens. For the treatment of these patients, a wide range of drugs was used, including 13 groups of antibiotics. In most cases, the parenteral route of drug administration was used: intravenous route, 56.0%; intramuscular, 28.0%; and oral, 16.0%. The DDD analysis showed that antibiotic intake for the treatment of patients with HAPH was 137.8 NDDD/100 bed-days; surgical infection, 48.2 NDDD/100 bed-days (35.0%); and pneumonia, 89.6 NDDD/100 bed-days (65.0%). Cephalosporins were the most commonly used group of antibiotics for both surgical infection and pneumonia, mainly third-generation cephalosporins.
CONCLUSION: Etiological agents of HAPH are phenotypically similar to nosocomial strains. Among antibacterial drugs, cephalosporins and fluoroquinolones were mainly consumed, and HAPH isolates had unfavorable resistance profiles to these drugs.
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About the authors
Daria Yu. Perfileva
Siberian State Medical University
Email: perfileva.dy@ssmu.ru
ORCID iD: 0000-0002-1168-7405
SPIN-code: 6217-4710
ResearcherId: AAC-2941-2021
Russian Federation, Moscow tract, 2, 634050 Tomsk
Alexander G. Miroshnichenko
South Ural State Medical University
Email: ag.miro@yandex.ru
ORCID iD: 0000-0003-4035-8341
SPIN-code: 8176-3150
MD, dr. sci. (med.), associate professor
Russian Federation, 64 Vorovskogo street, 454092 ChelyabinskVyacheslav Yu. Perfilev
Siberian State Medical University
Email: p.v.yu@mail.ru
ORCID iD: 0000-0001-6958-6423
SPIN-code: 7463-1850
MD, cand. sci. (med.)
Russian Federation, Moscow tract, 2, 634050 TomskEvgeny S. Kulikov
Siberian State Medical University
Email: kulikov.es@ssmu.ru
ORCID iD: 0000-0002-0088-9204
SPIN-code: 9934-1476
MD, dr. sci. (med.), associate professor
Russian Federation, Moscow tract, 2, 634050 TomskVadim A. Boykov
Siberian State Medical University
Email: boykov85@mail.ru
ORCID iD: 0000-0001-7532-7102
SPIN-code: 9747-9288
MD, dr. sci. (med.), associate professor
Russian Federation, Moscow tract, 2, 634050 TomskSofia V. Nesterovich
Siberian State Medical University
Email: snesterovich@mail.ru
ORCID iD: 0000-0003-2098-2964
SPIN-code: 1814-1577
MD, cand. sci. (med.)
Russian Federation, Moscow tract, 2, 634050 TomskAnastasia P. Zima
Siberian State Medical University
Author for correspondence.
Email: zima2302@gmail.com
ORCID iD: 0000-0002-9034-7264
SPIN-code: 5710-4547
MD, dr. sci. (med.), associate professor
Russian Federation, Moscow tract, 2, 634050 TomskReferences
- Safavi A, Molavynejad S, Rashidi M, et al. The effect of an infection control guideline on the incidence of ventilator-associated pneumonia in patients admitted to the intensive care units. BMC Infect Dis. 2023;23(1):198. doi: 10.1186/s12879-023-08151-w
- Morozov AM, Zhukov SV, Belyak MA, Stamenkovich AB. Assessment of economic losses due to the development of infection in the surgical intervention area. Manager Zdravoohranenia. 2022;1:54–60. (In Russ). doi: 10.21045/1811-0185-2022-1-54-60
- Gabrielyan NI, Sharapchenko SО, Kisil ОV, et al. Epidemiology issues in problem of antibiotic resistance of clinical pathogens. Medical alphabet. 2020;(34):6–8. (In Russ). doi: 10.33667/2078-5631-2020-34-6-8
- Polushin YuS, Shlyk IV. Can the efficacy of anti-bacterial therapy of nosocomial infections be enhanced? Messenger of Anesthesiology and Resuscitation. 2020;17(1):6–8. (In Russ). doi: 10.21292/2078-5658-2020-17-1-6-8
- Herrera S, Torralbo B, Herranz S, et al. Carriage of multidrug-resistant Gram-negative bacilli: duration and risk factors. Eur J Clin Microbiol Infect Dis. 2023;42(5):631–638. doi: 10.1007/s10096-023-04581-1
- Weiner-Lastinger LM, Abner S, Edwards JR, et al. Antimicrobial-resistant pathogens associated with adult healthcare-associated infections: summary of data reported to the National Healthcare Safety Network, 2015–2017. Infect Control Hosp Epidemiol. 2020;41(1):1–18. doi: 10.1017/ice.2019.296
- Yakovlev SV, Suvorova MP, Beloborodov VB, et al. Multicentre study of the prevalence and clinical value of hospital-acquired infections in emergency hospitals of Russia: ERGINI Study. Antibiotiki i Khimioterapiya. 2016;61(5-6):32–42. (In Russ).
- Voropaeva NM, Nemchenko UM, Grigorova EV, et al. Structure and antibiotic resistance of the main causative agents of infections associated with the provision of medical care. Epidemiology and Vaccinal Prevention. 2023;22(1):68–73. (In Russ). doi: 10.31631/2073-3046-2023-22-1-68-73
- Kuzmenkov AYu, Vinogradova AG, Trushin IV, et al. AMRmap — antibiotic resistance surveillance system in Russia. Clinical Microbiology and Antimicrobial Chemotherapy. 2021;23(2):198–204. (In Russ). doi: 10.36488/cmac.2021.2.198-204
- Olivares E, Badel-Berchoux S, Provot C, et al. Clinical impact of antibiotics for the treatment of Pseudomonas aeruginosa biofilm infections. Front Microbiol. 2020;10:2894. doi: 10.3389/fmicb.2019.02894
- Heidari R, Farajzadeh Sheikh A, Hashemzadeh M, et al. Antibiotic resistance, biofilm production ability and genetic diversity of carbapenem-resistant Pseudomonas aeruginosa strains isolated from nosocomial infections in southwestern Iran. Mol Biol Rep. 2022;49(5):3811–3822. doi: 10.1007/s11033-022-07225-3
- Yang X, Guo R, Zhang B, et al. Retrospective analysis of drug resistance characteristics and infection related risk factors of multidrug-resistant organisms (MDROs) isolated from the orthopedics department of a tertiary hospital. Sci Rep. 2023;13(1):2199. doi: 10.1038/s41598-023-28270-3
- Kishita M, Matsumura Y, Yamamoto M, et al. Increase in the frequency of community-acquired methicillin-resistant Staphylococcus aureus clones among inpatients of acute care hospitals in the Kyoto and Shiga regions, Japan. J Infect Chemother. 2023;29(5):458–463. doi: 10.1016/j.jiac.2023.01.013