DIACYLGLYCERIDES AS NUTRITION COMPONENTS OR PRECURSORS OF CARCINOGENS: A CRITICAL VIEW ON AN AMBULAR QUESTION



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Abstract

Obesity is recognized as a non-infectious epidemic worldwide. Metabolic disorders associated with the accumulation of adipose tissue lead to the progression of obesity-associated diabetes mellitus and cardiovascular diseases. Diet is one of the components of treatment of the diseases associated with obesity. The most commonly used diets are caloric restriction by reducing fat in the diet. Over the past few decades, there have been many attempts to use diacylglycerol (DAG) as components of dietary oils. This was due to the ability of DAG to suppress the accumulation of visceral fat, to reduce postprandial levels of triacylglycerol and cholesterol, and glucose in the blood serum. However, in 2009 it was found that when oil was processed at high temperatures during physical refining, DAG-enriched oil had the highest levels of potentially harmful glycidol esters (GE) compared to conventional refined fats and oils. The study of the negative effects of GE has prompted the food industry, which has traditionally used oil, to focus on strategies to prevent or mitigate these effects by changing the refining process or modifying deodorization equipment to reduce or eliminate process contaminants.

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About the authors

Andrey V. Budnevsky

Voronezh State Medical University named after N.N. Burdenko

Email: budnev@list.ru
ORCID iD: 0000-0002-1171-2746
SPIN-code: 7381-0612
ResearcherId: L-7459-2016

MD, PhD, ScD, Professor, Head of the Department of Faculty Therapy, Vice-Rector for Scientific and Innovation Activities 

Russian Federation, 10, Studencheskaya st., Voronezh, 394036, Russia

Evgeniy S. Ovsyannikov

Voronezh State Medical University named after N.N. Burdenko

Email: ovses@yandex.ru
ORCID iD: 0000-0002-8545-6255
SPIN-code: 7999-0433

MD, PhD, ScD, Professor, Department of Faculty therapy

Russian Federation, 10, Studencheskaya st., Voronezh, 394036, Russia

Valery I. Popov

Voronezh State Medical University named after N.N. Burdenko

Email: 9038504004@mail.ru
ORCID iD: 0000-0001-5386-9082
SPIN-code: 8896-9019

MD, PhD, ScD, Corresponding Member of RAS, Professor, Head of the Department of General Hygiene

Russian Federation, 10, Studencheskaya st., Voronezh, 394036, Russia

Elena S. Drobysheva

Voronezh State Medical University named after N.N. Burdenko

Email: e.drobysheva76@mail.ru
ORCID iD: 0000-0003-2132-8374
SPIN-code: 5342-2742

MD, PhD, Associate professor, Department of Faculty Therapy

Russian Federation, 10, Studencheskaya st., Voronezh, 394036, Russia

Sofia N. Feigelman

Voronezh State Medical University named after N.N. Burdenko

Author for correspondence.
Email: s.feygelman@gmail.com
ORCID iD: 0000-0003-4128-6044
SPIN-code: 1645-1203

Assistant, Department of Faculty Therapy

Russian Federation, 10, Studencheskaya st., Voronezh, 394036, Russia

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