SLEEP DISTURBANCE. FROM INSONALITY TO DEPRESSION. FROM ANIMALS TO HUMANS



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Abstract

The review presents data on the pathophysiology of sleep disorders and the epidemiology of this disease. Current data from clinical studies and the results of meta-analyses are presented, showing the key factors in the influence of sleep deprivation on the human body. A close connection between sleep disorders and depressive disorders has been shown. The role of sleep deprivation as one of the methods of depression therapy is discussed. Sleep deprivation models in laboratory animals are presented and classified. Examples of behavioral disorders of animals and biochemical markers after using various sleep deprivation techniques are given. The prospects for further preclinical research in the field of sleep pathology are shown.

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About the authors

Denis Borozdenko

The Russian National Research Medical University named after N.I. Pirogov Institute of Pharmacy and Medical Chemistry

Author for correspondence.
Email: borozdenko@phystech.edu
ORCID iD: 0000-0002-6797-9722
Scopus Author ID: 55185198400

ассистент кафедры фармакологии ИФМХ

Russian Federation, 117997, Russian Federation, Moscow, st. Ostrovityanova, 1

Vladislav Yankovsky

The Russian National Research Medical University named after N.I. Pirogov Institute of Pharmacy and Medical Chemistry

Email: vld.s.yan567@gmail.com
ORCID iD: 0009-0002-3337-9048

Студент

Russian Federation, 117997, Russian Federation, Moscow, st. Ostrovityanova, 1

Vadim V. Negrebetsky

N.I. Pirogov Russian National Research Medical University

Email: nmr_rsmu@yahoo.com
ORCID iD: 0000-0001-6852-8942

MD, Cand. Sci. (Chem.), Professor

Russian Federation, 1 Ostrovityanova str., 117997, Moscow

References

  1. Jerome M Siegel, Chapter 10 - REM Sleep, Principles and Practice of Sleep Medicine (Fourth Edition), WB Saunders, 2005; 120-135, ISBN 9780721607979, https://doi.org/10.1016/B0-72-160797-7/50017-3.
  2. Patel AK, Reddy V, Shumway KR, et al. Physiology, Sleep Stages. [Updated 2022 Sep 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526132/
  3. Payne JD, Schacter DL, Propper RE, Huang LW, Wamsley EJ, Tucker MA, Walker MP, Stickgold R. The role of sleep in false memory formation. Neurobiol Learn Mem. 2009 Oct;92(3):327-34. doi: 10.1016/j.nlm.2009.03.007. Epub 2009 Apr 5. PMID: 19348959; PMCID: PMC2789473.
  4. Gandhi MH, Emmady PD. Physiology, K Complex. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32491401.
  5. Partch, Carrie L et al. “Molecular architecture of the mammalian circadian clock.” Trends in cell biology vol. 24,2 (2014): 90-9. doi: 10.1016/j.tcb.2013.07.002
  6. Rosenwasser AM, Turek FW. Neurobiology of Circadian Rhythm Regulation. Sleep Med Clin. 2015 Dec;10(4):403-12. doi: 10.1016/j.jsmc.2015.08.003. Epub 2015 Sep 11. PMID: 26568118.
  7. Brunner DP, Dijk DJ, Borbély AA. Repeated partial sleep deprivation progressively changes in EEG during sleep and wakefulness. Sleep. 1993 Feb;16(2):100-13. doi: 10.1093/sleep/16.2.100. PMID: 8446828.
  8. Kerkhof GA. Epidemiology of sleep and sleep disorders in The Netherlands. Sleep Med. 2017 Feb;30:229-239. doi: 10.1016/j.sleep.2016.09.015. Epub 2016 Nov 5. PMID: 28215254.
  9. Perotta B, Arantes-Costa FM, Enns SC, Figueiro-Filho EA, Paro H, Santos IS, Lorenzi-Filho G, Martins MA, Tempski PZ. Sleepiness, sleep deprivation, quality of life, mental symptoms and perception of academic environment in medical students. BMC Med Educ. 2021 Feb 17;21(1):111. doi: 10.1186/s12909-021-02544-8. PMID: 33596885; PMCID: PMC7890911.
  10. Seoane HA, Moschetto L, Orliacq F, Orliacq J, Serrano E, Cazenave MI, Vigo DE, Perez-Lloret S. Sleep disruption in medicine students and its relationship with impaired academic performance: A systematic review and meta-analysis. Sleep Med Rev. 2020 Oct;53:101333. doi: 10.1016/j.smrv.2020.101333. Epub 2020 May 15. PMID: 32485517.
  11. Tomaso CC, Johnson AB, Nelson TD. The effect of sleep deprivation and restriction on mood, emotion, and emotion regulation: three meta-analyses in one. Sleep. 2021 Jun 11;44(6):zsaa289. doi: 10.1093/sleep/zsaa289. PMID: 33367799; PMCID: PMC8193556
  12. Köhler CA, Freitas TH, Maes M, de Andrade NQ, Liu CS, Fernandes BS, Stubbs B, Solmi M, Veronese N, Herrmann N, Raison CL, Miller BJ, Lanctôt KL, Carvalho AF. Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies. Acta Psychiatr Scand. 2017 May;135(5):373-387. doi: 10.1111/acps.12698. Epub 2017 Jan 25. PMID: 28122130.
  13. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctôt KL. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010 Mar 1;67(5):446-57. doi: 10.1016/j.biopsych.2009.09.033. Epub 2009 Dec 16. PMID: 20015486.
  14. Liu Y, Ho RC, Mak A. Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. J Affect Disord. 2012 Aug;139(3):230-9. doi: 10.1016/j.jad.2011.08.003. Epub 2011 Aug 26. PMID: 21872339.
  15. Kim YK, Won E. The influence of stress on neuroinflammation and alterations in brain structure and function in major depressive disorder. Behav Brain Res. 2017 Jun 30;329:6-11. doi: 10.1016/j.bbr.2017.04.020. Epub 2017 Apr 22. PMID: 28442354.
  16. Belmaker RH, Agam G. Major depressive disorder. N Engl J Med. 2008 Jan 3;358(1):55-68. doi: 10.1056/NEJMra073096. PMID: 18172175.
  17. Asberg M, Thorén P, Träskman L, Bertilsson L, Ringberger V. "Serotonin depression"--a biochemical subgroup within the affective disorders? Science. 1976 Feb 6;191(4226):478-80. doi: 10.1126/science.1246632. PMID: 1246632.
  18. Mulinari S. Monoamine theories of depression: historical impact on biomedical research. J Hist Neurosci. 2012;21(4):366-92. doi: 10.1080/0964704X.2011.623917. PMID: 22947380.
  19. Stahl SM, Lee-Zimmerman C, Cartwright S, Morrissette DA. Serotonergic drugs for depression and beyond. Curr Drug Targets. 2013 May 1;14(5):578-85. doi: 10.2174/1389450111314050007. PMID: 23531115.
  20. March JS, Silva S, Petrycki S, Curry J, Wells K, Fairbank J, Burns B, Domino M, McNulty S, Vitiello B, Severe J. The Treatment for Adolescents With Depression Study (TADS): long-term effectiveness and safety outcomes. Arch Gen Psychiatry. 2007 Oct;64(10):1132-43. doi: 10.1001/archpsyc.64.10.1132. Erratum in: Arch Gen Psychiatry. 2008 Jan;65(1):101. PMID: 17909125.
  21. Abolfazli R, Hosseini M, Ghanizadeh A, Ghaleiha A, Tabrizi M, Raznahan M, Golalizadeh M, Akhondzadeh S. Double-blind randomized parallel-group clinical trial of efficacy of the combination fluoxetine plus modafinil versus fluoxetine plus placebo in the treatment of major depression. Depress Anxiety. 2011 Apr;28(4):297-302. doi: 10.1002/da.20801. Epub 2011 Feb 24. PMID: 21456039.
  22. Joseph DN, Whirledge S. Stress and the HPA Axis: Balancing Homeostasis and Fertility. Int J Mol Sci. 2017 Oct 24;18(10):2224. doi: 10.3390/ijms18102224. PMID: 29064426; PMCID: PMC5666903.
  23. Packard AE, Egan AE, Ulrich-Lai YM. HPA Axis Interactions with Behavioral Systems. Compr Physiol. 2016 Sep 15;6(4):1897-1934. doi: 10.1002/cphy.c150042. PMID: 27783863; PMCID: PMC7219962.
  24. Spencer RL, Deak T. A users guide to HPA axis research. Physiol Behav. 2017 Sep 1;178:43-65. doi: 10.1016/j.physbeh.2016.11.014. Epub 2016 Nov 18. PMID: 27871862; PMCID: PMC5451309.
  25. Zajkowska Z, Gullett N, Walsh A, Zonca V, Pedersen GA, Souza L, Kieling C, Fisher HL, Kohrt BA, Mondelli V. Cortisol and development of depression in adolescence and young adulthood - a systematic review and meta-analysis. Psychoneuroendocrinology. 2022 Feb;136:105625. doi: 10.1016/j.psyneuen.2021.105625. Epub 2021 Dec 8. PMID: 34920399; PMCID: PMC8783058.
  26. Li X, Wu T, Yu Z, Li T, Zhang J, Zhang Z, Cai M, Zhang W, Xiang J, Cai D. Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis. Biomed Pharmacother. 2018 Apr;100:394-406. doi: 10.1016/j.biopha.2018.01.137. Epub 2018 Feb 16. PMID: 29454288.
  27. Kv A, Madhana RM, Js IC, Lahkar M, Sinha S, Naidu VGM. Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice. Behav Brain Res. 2018 May 15;344:73-84. doi: 10.1016/j.bbr.2018.02.009. Epub 2018 Feb 13. Erratum in: Behav Brain Res. 2019 Feb 1;359:973-974. PMID: 29452193.]
  28. Roberts RE, Duong HT. The prospective association between sleep deprivation and depression among adolescents. Sleep. 2014 Feb 1;37(2):239-44. doi: 10.5665/sleep.3388. PMID: 24497652; PMCID: PMC3900610.
  29. Dong L, Xie Y, Zou X. Association between sleep duration and depression in US adults: A cross-sectional study. J Affect Disord. 2022 Jan 1;296:183-188. doi: 10.1016/j.jad.2021.09.075. Epub 2021 Sep 28. PMID: 34607059.
  30. Kupfer DJ, Foster FG. Interval between onset of sleep and rapid-eye-movement sleep as an indicator of depression. Lancet. 1972 Sep 30;2(7779):684-6. doi: 10.1016/s0140-6736(72)92090-9. PMID: 4115821.
  31. Zarcone VP Jr, Benson KL. Increased REM eye movement density in self-rated depression. Psychiatry Res. 1983 Jan;8(1):65-71. doi: 10.1016/0165-1781(83)90140-3. PMID: 6572989.
  32. Crișan CA, Milhem Z, Stretea R, Țața IM, Cherecheș RM, Micluția IV. A Narrative Review on REM Sleep Deprivation: A Promising Non-Pharmaceutical Alternative for Treating Endogenous Depression. J Pers Med. 2023 Feb 10;13(2):306. doi: 10.3390/jpm13020306. PMID: 36836540; PMCID: PMC9960519.
  33. Benca RM, Obermeyer WH, Thisted RA, Gillin JC. Sleep and psychiatric disorders. A meta-analysis. Arch Gen Psychiatry. 1992 Aug;49(8):651-68; discussion 669-70. doi: 10.1001/archpsyc.1992.01820080059010. PMID: 1386215.
  34. Landsness EC, Goldstein MR, Peterson MJ, Tononi G, Benca RM. Antidepressant effects of selective slow wave sleep deprivation in major depression: a high-density EEG investigation. J Psychiatr Res. 2011 Aug;45(8):1019-26. doi: 10.1016/j.jpsychires.2011.02.003. Epub 2011 Mar 11. PMID: 21397252; PMCID: PMC3119746.
  35. Hu B, Liu C, Mou T, Luo F, Lv T, Qian C, Zhang J, Ye M, Liu Z. Meta-Analysis of Sleep Deprivation Effects on Patients With Depression. Front Psychiatry. 2021 Nov 30;12:783091. doi: 10.3389/fpsyt.2021.783091. PMID: 34916978; PMCID: PMC8669147.
  36. Chai Y, Gehrman P, Yu M, Mao T, Deng Y, Rao J, Shi H, Quan P, Xu J, Zhang X, Lei H, Fang Z, Xu S, Boland E, Goldschmied JR, Barilla H, Goel N, Basner M, Thase ME, Sheline YI, Dinges DF, Detre JA, Zhang X, Rao H. Enhanced amygdala-cingulate connectivity associates with better mood in both healthy and depressive individuals after sleep deprivation. Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2214505120. doi: 10.1073/pnas.2214505120. Epub 2023 Jun 20. PMID: 37339227; PMCID: PMC10293819.
  37. Goldschmied JR, Boland E, Palermo E, Barilla H, Dinges DF, Detre JA, Basner M, Sheline YI, Rao H, Gehrman P. Antidepressant effects of acute sleep deprivation are reduced in highly controlled environments. J Affect Disord. 2023 Nov 1;340:412-419. doi: 10.1016/j.jad.2023.07.116. Epub 2023 Aug 6. PMID: 37553017; PMCID: PMC10528033.
  38. Berro LF, Santos R, Hollais AW, Wuo-Silva R, Fukushiro DF, Mári-Kawamoto E, Costa JM, Trombin TF, Patti CL, Grapiglia SB, Tufik S, Andersen ML, Frussa-Filho R. Acute total sleep deprivation potentiates cocaine-induced hyperlocomotion in mice. Neurosci Lett. 2014 Sep 5;579:130-3. doi: 10.1016/j.neulet.2014.07.028. Epub 2014 Jul 24. PMID: 25067829.
  39. Fenzl T, Romanowski CP, Flachskamm C, Honsberg K, Boll E, Hoehne A, Kimura M. Fully automated sleep deprivation in mice as a tool in sleep research. J Neurosci Methods. 2007 Nov 30;166(2):229-35. doi: 10.1016/j.jneumeth.2007.07.007. Epub 2007 Jul 24. Erratum in: J Neurosci Methods. 2008 May 15;170(1):179. PMID: 17825425.
  40. Rechtschaffen A, Gilliland MA, Bergmann BM, Winter JB. Physiological correlates of prolonged sleep deprivation in rats. Science. 1983 Jul 8;221(4606):182-4. doi: 10.1126/science.6857280. PMID: 6857280.
  41. Lopez-Rodriguez F, Kim J, Poland RE. Total sleep deprivation decreases immobility in the forced-swim test. Neuropsychopharmacology. 2004 Jun;29(6):1105-11. doi: 10.1038/sj.npp.1300406. PMID: 14970835.
  42. Rechtschaffen A, Bergmann BM. Sleep deprivation in the rat by the disk-over-water method. Behav Brain Res. 1995 Jul-Aug;69(1-2):55-63. doi: 10.1016/0166-4328(95)00020-t. PMID: 7546318.
  43. Franken P, Tobler I, Borbély AA. Effects of 12-h sleep deprivation and of 12-h cold exposure on sleep regulation and cortical temperature in the rat. Physiol Behav. 1993 Nov;54(5):885-94. doi: 10.1016/0031-9384(93)90297-s. PMID: 8248378.
  44. Lemons A, Saré RM, Beebe Smith C. Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling. J Vis Exp. 2018 Oct 11;(140):58150. doi: 10.3791/58150. PMID: 30371669; PMCID: PMC6235482.
  45. Cohen HB, Dement WC. Sleep: changes in threshold to electroconvulsive shock in rats after deprivation of "paradoxical" phase. Science. 1965 Dec 3;150(3701):1318-9. doi: 10.1126/science.150.3701.1318. PMID: 5857002.
  46. Mendelson WB, Guthrie RD, Frederick G, Wyatt RJ. The flower pot technique of rapid eye movement (REM) sleep deprivation. Pharmacol Biochem Behav. 1974 Jul-Aug;2(4):553-6. doi: 10.1016/0091-3057(74)90018-5. PMID: 4371007.
  47. Youngblood BD, Zhou J, Smagin GN, Ryan DH, Harris RB. Sleep deprivation by the "flower pot" technique and spatial reference memory. Physiol Behav. 1997 Feb;61(2):249-56. doi: 10.1016/s0031-9384(96)00363-0. PMID: 9035255.
  48. Suchecki D, Duarte Palma B, Tufik S. Sleep rebound in animals deprived of paradoxical sleep by the modified multiple platform method. Brain Res. 2000 Sep 1;875(1-2):14-22. doi: 10.1016/s0006-8993(00)02531-2. PMID: 10967294.
  49. Machado RB, Hipólide DC, Benedito-Silva AA, Tufik S. Sleep deprivation induced by the modified multiple platform technique: quantification of sleep loss and recovery. Brain Res. 2004 Apr 9;1004(1-2):45-51. doi: 10.1016/j.brainres.2004.01.019. PMID: 15033418.
  50. Han C, Li F, Ma J, Liu Y, Li W, Mao Y, Song Y, Guo S, Liu J. Distinct behavioral and brain changes after different durations of the modified multiple platform method on rats: An animal model of central fatigue. PLoS One. 2017 May 11;12(5):e0176850. doi: 10.1371/journal.pone.0176850. PMID: 28493899; PMCID: PMC5426622.
  51. Shinomiya K, Shigemoto Y, Okuma C, Mio M, Kamei C. Effects of short-acting hypnotics on sleep latency in rats placed on grid suspended over water. Eur J Pharmacol. 2003 Jan 24;460(2-3):139-44. doi: 10.1016/s0014-2999(02)02915-1. PMID: 12559374.
  52. Utsu Y, Shinomiya K, Tokunaga S, Ohmori A, Kamei C. Effect of tandospirone on sleep latency in rats placed on a grid suspended over water. J Pharmacol Sci. 2007 Sep;105(1):112-6. doi: 10.1254/jphs.fp0070981. Epub 2007 Sep 8. PMID: 17827866.
  53. Chanana P, Kumar A. GABA-BZD Receptor Modulating Mechanism of Panax quinquefolius against 72-h Sleep Deprivation Induced Anxiety like Behavior: Possible Roles of Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation. Front Neurosci. 2016 Mar 7;10:84. doi: 10.3389/fnins.2016.00084. PMID: 27013946; PMCID: PMC4779932.
  54. Kumar A, Singh A. Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. Fundam Clin Pharmacol. 2009 Aug;23(4):439-48. doi: 10.1111/j.1472-8206.2009.00737.x. PMID: 19709322.
  55. Kumar A, Singh A. Protective effect of St. John's wort (Hypericum perforatum) extract on 72-hour sleep deprivation-induced anxiety-like behavior and oxidative damage in mice. Planta Med. 2007 Oct;73(13):1358-64. doi: 10.1055/s-2007-990234. Epub 2007 Oct 4. PMID: 17918039.
  56. Chen D, Zhang Y, Wang C, Wang X, Shi J, Zhang J, Guan W, Li B, Fan W. Modulation of hippocampal dopamine and synapse-related proteins by electroacupuncture improves memory deficit caused by sleep deprivation. Acupunct Med. 2020 Oct;38(5):343-351. doi: 10.1177/0964528420902147. Epub 2020 May 5. PMID: 32370535.
  57. da Silva Rocha-Lopes J, Machado RB, Suchecki D. Chronic REM Sleep Restriction in Juvenile Male Rats Induces Anxiety-Like Behavior and Alters Monoamine Systems in the Amygdala and Hippocampus. Mol Neurobiol. 2018 Apr;55(4):2884-2896. doi: 10.1007/s12035-017-0541-3. Epub 2017 Apr 28. PMID: 28455701.
  58. Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA, Benjamins JS, Muñoz-Manchado AB, Nagel M, Savage JE, Tiemeier H, White T; 23andMe Research Team; Tung JY, Hinds DA, Vacic V, Wang X, Sullivan PF, van der Sluis S, Polderman TJC, Smit AB, Hjerling-Leffler J, Van Someren EJW, Posthuma D. Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways. Nat Genet. 2019 Mar;51(3):394-403. doi: 10.1038/s41588-018-0333-3. Epub 2019 Feb 25. PMID: 30804565.
  59. Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman JW, Winkelmann J; HUNT All In Sleep; Hveem K, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart JA, Brumpton B, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena R. Biological and clinical insights from genetics of insomnia symptoms. Nat Genet. 2019 Mar;51(3):387-393. doi: 10.1038/s41588-019-0361-7. Epub 2019 Feb 25. PMID: 30804566; PMCID: PMC6415688.
  60. Heninger GR, Delgado PL, Charney DS. The revised monoamine theory of depression: a modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans. Pharmacopsychiatry. 1996 Jan;29(1):2-11. doi: 10.1055/s-2007-979535. PMID: 8852528.
  61. Jeon SW, Kim YK. Neuroinflammation and cytokine abnormality in major depression: Cause or consequence in that illness? World J Psychiatry. 2016 Sep 22;6(3):283-93. doi: 10.5498/wjp.v6.i3.283. PMID: 27679767; PMCID: PMC5031928.
  62. Ramírez LA, Pérez-Padilla EA, García-Oscos F, Salgado H, Atzori M, Pineda JC. A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis. Biomedica. 2018 Sep 1;38(3):437-450. doi: 10.7705/biomedica.v38i3.3688. PMID: 30335249.
  63. Wang Z, Chen L, Zhang L, Wang X. Paradoxical sleep deprivation modulates depressive-like behaviors by regulating the MAOA levels in the amygdala and hippocampus. Brain Res. 2017 Jun 1;1664:17-24. doi: 10.1016/j.brainres.2017.03.022. Epub 2017 Mar 29. PMID: 28365314.
  64. Liang X, Hou Z, Chen L, Wang Y, Hua K, Sun Y. 睡眠剥夺对海马区单胺类神经递质、氨基酸代谢及小鼠行为的影响 [Effect of Sleep Deprivation on the Metabolism of Hippocampal Amino Acids and Monoamine Neurotransmitters in Mice and Their Behaviors]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 Nov 20;54(6):1139-1145. Chinese. doi: 10.12182/20231160203. PMID: 38162057; PMCID: PMC10752789.
  65. Axelsson J, Rehman JU, Akerstedt T, Ekman R, Miller GE, Höglund CO, Lekander M. Effects of sustained sleep restriction on mitogen-stimulated cytokines, chemokines and T helper 1/ T helper 2 balance in humans. PLoS One. 2013 Dec 11;8(12):e82291. doi: 10.1371/journal.pone.0082291. PMID: 24349251; PMCID: PMC3859577.
  66. Rico-Rosillo MG, Vega-Robledo GB. Sueño y sistema immune [Sleep and immune system]. Rev Alerg Mex. 2018 Apr-Jun;65(2):160-170. Spanish. doi: 10.29262/ram.v65i2.359. PMID: 29983013.
  67. Gonzalez-Castañeda RE, Galvez-Contreras AY, Martínez-Quezada CJ, Jauregui-Huerta F, Grcia-Estrada J, Ramos-Zuñiga R, Luquin S, Gonzalez-Perez O. Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice. Exp Anim. 2016;65(1):97-107. doi: 10.1538/expanim.15-0054. Epub 2015 Nov 6. PMID: 26548630; PMCID: PMC4783655.
  68. Xia M, Li Z, Li S, Liang S, Li X, Chen B, Zhang M, Dong C, Verkhratsky A, Guan D, Li B. Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT2B Receptors and Triggers Depressive-Like Behaviors via Stimulating P2X7 Receptors in Mice. Neurosci Bull. 2020 Nov;36(11):1259-1270. doi: 10.1007/s12264-020-00524-4. Epub 2020 Jun 6. PMID: 32506374; PMCID: PMC7674526.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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