The relationship between Crohn's disease and the intestinal microbiota in the elderly.Literary review.
- Authors: Vereschagina A.D.1, Shelyakina A.V.1, Smirnova T.K.1, Dulepova R.V.1, Borodkina L.V.1, Vladimirova V.S.1, Raevskii K.P.1
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Affiliations:
- North-Western State Medical University named after I.I.Mechnikov
- Section: Reviews
- Submitted: 26.03.2025
- Accepted: 05.06.2025
- Published: 17.06.2025
- URL: https://medjrf.com/0869-2106/article/view/677754
- DOI: https://doi.org/10.17816/medjrf677754
- ID: 677754
Cite item
Abstract
Crohn's disease (CD) is a chronic, recurrent inflammatory disease of the gastrointestinal tract that occurs against the background of a complex interaction between the immune system and the microbiota. In recent years, there has been an increase in the incidence of CD, especially among the young and elderly. This article examines current data on changes in the microbiota in patients with CD, with an emphasis on the elderly. This article analyzes the scientific literature over the past 5 years from the following scientific databases: Medline, PubMed Central, E-library, Cyberleninka. The study showed that dysbiosis of the intestinal microbiota, which is observed in most patients, leads to a decrease in the diversity of bacteria and an increase in pathogenic microorganisms, which is directly related to the worsening of the disease.
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About the authors
Alexandra Dmitrievna Vereschagina
North-Western State Medical University named after I.I.Mechnikov
Author for correspondence.
Email: alexver20010419@gmail.com
ORCID iD: 0009-0004-7880-8314
The 6th year student
Russian FederationAlina Vladimirovna Shelyakina
Email: shelyakinalina@yandex.ru
ORCID iD: 0009-0006-5932-3850
Tatyana Konstantinovna Smirnova
Email: frutany91@gmail.com
ORCID iD: 0009-0002-9568-1322
Regina Vladimirovna Dulepova
Email: reginakrrz@gmail.com
ORCID iD: 0009-0001-7145-4718
Lidia Vadimovna Borodkina
Email: borodkinalv00@mail.ru
ORCID iD: 0009-0003-2498-5182
Veronika Stanislavovna Vladimirova
Email: vladimirovav19@yandex.ru
ORCID iD: 0009-0000-2652-6279
Kirill Pavlovich Raevskii
Email: raevskiikp@my.msu.ru
ORCID iD: 0000-0002-9939-3443
References
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