Interrelation between gut microbiota and bronchial asthma

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Bronchial asthma is a chronic disease of the respiratory tract, and its etiology and pathogenesis have not been studied adequately. Many authors suggest that intestinal microbiota significantly contributed to its etiology. The existence of a gut–lung connection, through which bacterial metabolites influence airway sensibilization, has been proven. Certainly, the formation of this connection in childhood is important. This study provides a review of indigenous and foreign studies concerning the influence of the quantitative and qualitative compositions of intestinal microbiota and certain metabolites of commensals on the manifestation of bronchial asthma. This topic is relevant because of the widespread overuse of antibiotic therapy and the availability of possible ways to prevent the development of bronchial asthma if the influence of the microbiota on its pathogenesis is detected.

This study also tried to examine the influence of antibiotic therapy on pregnant women and young children at risk of bronchial asthma, a relationship confirmed in many studies. Despite the large number of studies, the use of probiotics for the treatment and prevention of this disease is still debatable.

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作者简介

Anastasia Potaman

Academician I.P. Pavlov First St. Petersburg State Medical University

编辑信件的主要联系方式.
Email: mpsakura@yandex.ru
ORCID iD: 0009-0001-5433-1783
俄罗斯联邦, Saint Petersburg

Polina Pyatysheva

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: polina.pyatysheva@gmail.com
ORCID iD: 0009-0003-1079-2558
俄罗斯联邦, Saint Petersburg

Ksenia Plotnikova

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: missis.plotnikova-xiusha@yandex.ru
ORCID iD: 0009-0008-3045-8764
俄罗斯联邦, Saint Petersburg

Maria-Mishel Kobak

St. Petersburg State Pediatric Medical University

Email: mariamishelkobak@gmail.com
ORCID iD: 0009-0006-2683-8348
SPIN 代码: 4955-4997
俄罗斯联邦, Saint Petersburg

Ahmed Abdusalamov

Military Medical Academy named after S.M. Kirov

Email: abdusalamoff.13@mail.ru
ORCID iD: 0009-0005-0652-1469
SPIN 代码: 7907-3271
俄罗斯联邦, Saint Petersburg

Kirill Raevskiy

Military Medical Academy named after S.M. Kirov

Email: raevskiykirill17@gmail.com
ORCID iD: 0000-0002-9939-3443
SPIN 代码: 9133-3802
俄罗斯联邦, Saint Petersburg

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