Interrelation between gut microbiota and bronchial asthma



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Abstract

This article is a review of indigenous and foreign literature concerning the influence of the quantitative and qualitative composition of intestinal microbiota, as well as certain metabolites of bacteria-commensals, on the manifestation of bronchial asthma. This topic is particularly relevant nowadays due to the widespread overuse of antibiotic therapy, and additionally, the availability of possible ways to prevent the manifestation of this disease if the influence of the microbiota on the pathogenesis of bronchial asthma is detected. Bronchial asthma is a chronic disease of the respiratory tract with insufficiently studied etiology and pathogenesis. Many authors suggest a significant contribution of intestinal microbiota to the etiology of this pathology. The existence of a gut-lung axis, through which bacterial metabolites influence airway sensibilization, has been proven. Certainly, forming this connection in childhood plays an important role.

Of particular interest is the question of the influence of antibiotic therapy on pregnant women and young children at the risk of bronchial asthma, a relationship confirmed in many studies. However, despite the large number of articles, the use of probiotics for the treatment and prevention of this disease is still debatable.

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About the authors

Anastasia M. Potaman

Federal State Budgetary Educational Institution of Higher Education Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation

Author for correspondence.
Email: mpsakura@yandex.ru
ORCID iD: 0009-0001-5433-1783

студент

Russian Federation, 6-8 L’va Tolstogo street, 197022, Saint – Petersburg, Russia

Polina A. Pyatysheva

Federal State Budgetary Educational Institution of Higher Education Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation

Email: polina.pyatysheva@gmail.com
ORCID iD: 0009-0003-1079-2558

студент

Russian Federation

Ksenia A. Plotnikova

Federal State Budgetary Educational Institution of Higher Education Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation

Email: missis.plotnikova-xiusha@yandex.ru
ORCID iD: 0009-0008-3045-8764

студент

Russian Federation

Maria-Mishel M. Kobak

Saint-Petersburg State Pediatric Medical University

Email: mariamishelkobak@gmail.com
ORCID iD: 0009-0006-2683-8348
SPIN-code: 4955-4997

студент

Russian Federation

Ahmed R. Abdusalamov

Kirov Military medical academy

Email: abdusalamoff.13@mail.ru
ORCID iD: 0009-0005-0652-1469
SPIN-code: 7907-3271

студент

Russian Federation

Kirill P. Raevskiy

Kirov Military medical academy

Email: raevskiykirill17@gmail.com
ORCID iD: 0000-0002-9939-3443
SPIN-code: 9133-3802
Scopus Author ID: 57768476700

ординатор второго года обучения по специальности "Кардиология"

Russian Federation

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