电邮这篇文章 Bronchial asthma and obesity: features of systemic inflammation depending on the time of onset of asthma symptoms
- 作者: Anikin D.1,2, Solovieva I.A.1,2, Demko I.V.1,2, Sobko E.A.1,2, Gordeeva N.V.1,2, Kraposhina A.Y.1,2
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隶属关系:
- Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
- Krasnoyarsk Clinical Regional Hospital
- 栏目: Original Research Articles
- ##submission.dateSubmitted##: 13.12.2024
- ##submission.dateAccepted##: 22.08.2025
- ##submission.datePublished##: 28.09.2025
- URL: https://medjrf.com/0869-2106/article/view/642919
- DOI: https://doi.org/10.17816/medjrf642919
- ID: 642919
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BACKGROUND: Bronchial asthma (BA) is a complex heterogeneous polyetiological chronic disease. Pathophysiological mechanisms of interaction between bronchial asthma and obesity are of interest.
AIMS: Evaluation of cytokine profile features in patients with bronchial asthma with obesity, depending on the time of asthma onset.
MATERIALS AND METHODS: During the study, 180 people were examined: 150 patients with BA of varying severity, who were divided into groups based on BMI: group 1 included patients with BA with BMI from 18.5 to 25 kg/m2 (n=52), group 2 included patients with BA with BMI from 30 to 35 kg/m2 (n=98), the control group consisted of 30 people. Further, patients with asthma and obesity were divided depending on the time of asthma onset into the «Obesity + BA» group and the «BA + Obesity» group with asthma history of about 10 years. During the study, the severity of bronchial asthma was assessed using AST and ACQ tests, spirography with a bronchodilator test was performed, venous blood was collected to determine the cytokine profile (tumor necrosis factor-α; interleukins-2, 4, 6, 8, 10, 17; interferon-INF-γ), markers of systemic inflammation (C-reactive protein, fibrinogen).
RESULTS: The phenotype of bronchial asthma in combination with obesity was characterized by a more severe course, worse disease control, while in the «Obesity + BA» group, more severe bronchial patency disorders were recorded. When analyzing the cytokine profile in the study groups, a significant imbalance of proinflammatory and anti-inflammatory cytokines was noted, which was most pronounced in the «Obesity + BA» group. According to the data obtained, it was noted that it is important to determine the ratio index of various cytokines with opposite activity (IL-2 / IL-4, IL-2 / IL-10, IL-8 / IL-10, IL-6 / IL-10, TNF-α / IL-10) to determine the severity of the inflammatory process and further treatment tactics for patients.
CONCLUSIONS: Obesity leads to the formation and maintenance of systemic inflammation in the body and is a negative aggravating factor in the development and progression of BA.
全文:
作者简介
Dmitriy Anikin
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
Email: anikin27111994@mail.ru
ORCID iD: 0000-0002-1598-436X
assistant of Department of Hospital Therapy and Immunology with a Postgraduate Education Course; Pulmonologist of Department of Pulmonology
俄罗斯联邦, KrasnoyarskIrina Solovieva
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
Email: acad-prorector@krasgmu.ru
ORCID iD: 0000-0002-1999-9534
Dr. med. habil., associate professor, professor of the Department of hospital therapy and immunology with a postgraduate education course
KrasnoyarskIrina Demko
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
Email: demko64@mail.ru
ORCID iD: 0000-0001-8982-5292
MD, professor of Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia, head of the pulmonary and allergological center of Regional clinical hospital (Krasnoyarsk)
俄罗斯联邦, KrasnoyarskElena Sobko
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
Email: sobko29@mail.ru
ORCID iD: 0000-0002-9377-5213
MD, professor of Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of Russia, head of the Department of allergology of Regional clinical hospital (Krasnoyarsk)
俄罗斯联邦, KrasnoyarskNatalya Gordeeva
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
Email: natagorday@yandex.ru
ORCID iD: 0000-0002-0586-8349
PhD in Medicine, associate professor of the Department of hospital therapy and immunology with a postgraduate education course
KrasnoyarskAngelina Kraposhina
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Clinical Regional Hospital
编辑信件的主要联系方式.
Email: angelina-maria@inbox.ru
ORCID iD: 0000-0001-6896-877X
MD, PhD (Med.), Associate Professor of Department of Hospital Therapy and Immunology with a Postgraduate Education Course, Pulmonologist
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