STRUCTURAL AND FUNCTIONAL CHANGES IN THE RIGHT HEART IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME



如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Obstructive Sleep Apnea Syndrome (OSAS) is a widely prevalent condition in the global population. Despite its relatively short history of study, sufficient convincing data has accumulated regarding its negative impact on the cardiovascular system. However, the condition of the right heart chambers and the development of pulmonary hypertension in this patient cohort often remain outside the focus of attention due to disturbances in the hemodynamics of the small circulatory loop. Diagnosing right heart involvement in patients with obstructive sleep apnea syndrome is a complex task due to the absence of specific clinical features and the multimorbidity of such patients.

The aim of this review article is to demonstrate the results of original studies and meta-analyses dedicated to examining the structural and functional parameters of the right heart chambers, and to attempt to highlight the multifaceted nature of diagnosing pulmonary hypertension in patients with OSAS.

The literature review was conducted using medical abstract databases: PubMed (MEDLINE), ScienceDirect, and eLibrary.RU.

全文:

受限制的访问

作者简介

Anton Karasev

Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation; Moscow City Clinical Hospital 52

编辑信件的主要联系方式.
Email: akara95_2010@mail.ru
ORCID iD: 0000-0002-3863-6755
SPIN 代码: 2656-1420

PhD, Assistant of the Department of General Therapy of the Institute of Professional Development of the Federal State Autonomous Educational Institution of Higher Education, Russian National Research Medical University named after N.I. Pirogov of the Ministry of Health of the Russian Federation (Pirogov University), Physician of Functional Diagnostics of the Department of Ultrasound and Functional Diagnostics of the State Budgetary Institution "City Clinical Hospital 52

俄罗斯联邦, 1 bldg. Ostrovityanova ulitsa, Moscow 117513 Russia; 3 Pehotnaya ulitsa, Moscow, Russia, 123182

Natalia Poteshkina

Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation; Moscow City Clinical Hospital 52

Email: nat-pa@yandex.ru
ORCID iD: 0000-0001-9803-2139
SPIN 代码: 2863-4840
Scopus 作者 ID: 8434921700

MD, Dr. Sci. (Medicine), professor, Head of the Department of General Therapy, Institute of Professional Development, Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation (Pirogov University), Cardiologist, Cardiology Department, City Clinical Hospital No. 52

俄罗斯联邦, 1 bldg. Ostrovityanova ulitsa, Moscow 117513 Russia; 3 Pehotnaya ulitsa, Moscow, Russia, 123182

参考

  1. Platon A.L., Stelea C.G., Boișteanu O. et al. An Update on Obstructive Sleep Apnea Syndrome-A Literature Review. Medicina (Kaunas). 2023;59(8):1459. doi.org:10.3390/medicina59081459.
  2. Sarkar P., Mukherjee S., Chai-Coetzer C.L. et al. The epidemiology of obstructive sleep apnoea and cardiovascular disease. J Thorac Dis. 2018;10(Suppl 34):4189-4200. doi.org:10.21037/jtd.2018.12.56.
  3. Jayesh S.R., Bhat W.M. Mandibular advancement device for obstructive sleep apnea: An overview. J Pharm Bioallied Sci. 2015;7(Suppl 1):223-225. doi.org:10.4103/0975-7406.155915.
  4. Horvath C.M., Fisser C,. Floras J.S. et al. Nocturnal Cardiac Arrhythmias in Heart Failure With Obstructive and Central Sleep Apnea. Chest. 2024;166(6):1546-1556.
  5. doi.org:10.1016/j.chest.2024.08.003.
  6. Wang G., Miao H., Hao W. et al. Association of obstructive sleep apnoea with long-term cardiovascular events in patients with acute coronary syndrome with or without hypertension: insight from the OSA-ACS project. BMJ Open Respir Res. 2023;10(1):e001662.
  7. doi.org:10.1136/bmjresp-2023-001662.
  8. Ionin V.A., Pavlova V.A., Baranova E.I. Obstructive sleep apnea syndrome and cardiovascular diseases: from diagnosis to personalized therapy (part 2). Russian Journal for Personalized Medicine. 2022;2(2):54-62. doi.org:10.18705/2782-3806-2022-2-2-54-62. EDN CMFHOS.
  9. Heilbrunn E.S., Ssentongo P., Chinchilli V.M. et al. Sudden death in individuals with obstructive sleep apnoea: a systematic review and meta-analysis. BMJ Open Respir Res. 2021;8(1):e000656.
  10. doi.org:10.1136/bmjresp-2020-000656
  11. Hao W., Wang X., Fan J. et al. Association between apnea-hypopnea index and coronary artery calcification: a systematic review and meta-analysis. Ann Med. 2021;53(1):302-317. doi: 10.1080/07853890.2021.1875137
  12. Tung P., Levitzky Y.S., Wang R. et al. Obstructive and Central Sleep Apnea and the Risk of Incident Atrial Fibrillation in a Community Cohort of Men and Women. J Am Heart Assoc. 2017;6(7):e004500. doi.org:10.1161/JAHA.116.004500.
  13. Pearse S.G., Cowie M.R. Sleep-disordered breathing in heart failure. Eur J Heart Fail. 2016;18(4):353-61. doi.org:10.1002/ejhf.492.
  14. Read N., Jennings C., Hare A. Obstructive sleep apnoea-hypopnoea syndrome. Emerg Top Life Sci. 2023;7(5):467-476. doi.org:10.1042/ETLS20180939.
  15. Bonsignore M.R., Marrone O., Insalaco G. et al. The cardiovascular effects of obstructive sleep apnoeas: analysis of pathogenic mechanisms. Eur Respir J. 1994;7(4):786-805. doi.org: 10.1183/09031936.94.07040786.
  16. Tsipis A., Petropoulou E. Echocardiography in the Evaluation of the Right Heart. US Cardiol. 2022;16:e08. doi.org:10.15420/usc.2021.03.
  17. Balcan B., Akdeniz B., Peker Y., The Turcosact Collaborators. Obstructive Sleep Apnea and Pulmonary Hypertension: A Chicken-and-Egg Relationship. J Clin Med. 2024;13(10):2961. doi.org:10.3390/jcm13102961.
  18. Harańczyk M., Konieczyńska M., Płazak W. Endothelial dysfunction in obstructive sleep apnea patients. Sleep Breath. 2022;26(1):231-242. doi.org:10.1007/s11325-021-02382-4.
  19. Harańczyk M., Konieczyńska M., Płazak W. Influence of obstructive sleep apnea on right heart structure and function. Adv Respir Med. 2021;89(5):493-500. doi.org:10.5603/ARM.a2021.0095.
  20. Ibn Hadj Amor H., Touil I., Chebbi R. et al. Assessment of right ventricular remodeling and dysfunction in obstructive sleep apnea syndrome: a prospective monocentric study. Sleep Breath. 2022;26(2):663-674. doi.org:10.1007/s11325-021-02432-x.
  21. Maripov A., Mamazhakypov A., Sartmyrzaeva M. et al. Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis. Can Respir J. 2017;2017:1587865. doi.org:10.1155/2017/1587865.
  22. Vitarelli A., Terzano C., Saponara M. et al. Assessment of Right Ventricular Function in Obstructive Sleep Apnea Syndrome and Effects of Continuous Positive Airway Pressure Therapy: A Pilot Study. Can J Cardiol. 2015;31(7):823-831. doi.org: 10.1016/j.cjca.2015.01.029.
  23. D'Andrea A., Martone F., Liccardo B. et al. Acute and Chronic Effects of Noninvasive Ventilation on Left and Right Myocardial Function in Patients with Obstructive Sleep Apnea Syndrome: A Speckle Tracking Echocardiographic Study. Echocardiography. 2016;33(8):1144-55. doi.org:10.1111/echo.13225.
  24. Hammerstingl C., Schueler R., Wiesen M. et al. Effects of untreated obstructive sleep apnea on left and right ventricular myocardial function. Int J Cardiol. 2012;155(3):465-469.
  25. doi.org:10.1016/j.ijcard.2011.12.026.
  26. Macek P., Poręba M., Stachurska A. et al. Obstructive Sleep Apnea and Sleep Structure Assessed in Polysomnography and Right Ventricular Strain Parameters. Brain Sci. 2022;12(3):331.
  27. doi.org:10.3390/brainsci12030331.
  28. Li J., Lu C, Wang W., Gong K. et al. Assessment of right atrium dysfunction in patients with obstructive sleep apnea syndrome using velocity vector imaging. Cardiovasc Ultrasound. 2018;16(1):32.doi.org:10.1186/s12947-018-0150-y.
  29. Friedman S.E., Andrus B.W. Obesity and pulmonary hypertension: a review of pathophysiologic mechanisms. J Obes. 2012;2012:505274. doi.org:10.1155/2012/505274.
  30. Adir Y., Humbert M., Chaouat A. Sleep-related breathing disorders and pulmonary hypertension. Eur Respir J. 2021;57(1):2002258. doi.org:10.1183/13993003.02258-2020.
  31. Yeghiazarians Y., Jneid H., Tietjens J.R. et al. Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2021;144(3):e56-e67. doi: 10.1161/CIR.0000000000000988.
  32. Battaglia E., Compalati E., Mapelli L. et al. Pulmonary hypertension in patients affected by sleep-related breathing disorders: up to date from the literature. Minerva Med. 2024;115(6):671-688. doi.org: 10.23736/S0026-4806.24.09112-2.
  33. Minai O.A., Ricaurte B., Kaw R. et al. Frequency and impact of pulmonary hypertension in patients with obstructive sleep apnea syndrome. Am J Cardiol. 2009;104(9):1300-1306. doi.org: 10.1016/j.amjcard.2009.06.048. PMID:
  34. Yan L., Zhao Z., Zhao Q. et al. The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea. BMC Pulm Med. 2021;21(1):378.doi.org: 10.1186/s12890-021-01755-5.
  35. Akbari A., Raji H., Islampanah M. et al. Sleep apnea in pulmonary hypertension patients: a systematic review and meta-analysis sleep disorders and pulmonary hypertension. Sleep Breath. 2025;29(1):120. doi.org: 10.1007/s11325-025-03280-9.
  36. D., Wang T., Saunders NA. et al. Continuous positive airway pressure treatment improves pulmonary hemodynamics in patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2002;165(2):152-158. doi.org: 10.1164/ajrccm.165.2.2010092.
  37. Arias M.A., García-Río F., Alonso-Fernández A. et al. Pulmonary hypertension in obstructive sleep apnoea: effects of continuous positive airway pressure: a randomized, controlled cross-over study. Eur Heart J. 2006 May;27(9):1106-1113. doi.org:10.1093/eurheartj/ehi807.
  38. Imran T.F., Ghazipura M., Liu S. et al. Effect of continuous positive airway pressure treatment on pulmonary artery pressure in patients with isolated obstructive sleep apnea: a meta-analysis. Heart Fail Rev. 2016;21(5):591-598. doi.org:10.1007/s10741-016-9548-5

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Eco-Vector,


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия  ПИ № ФС 77 - 86296 от 11.12.2023 г. 
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80632 от 15.03.2021 г.