Email this article The specific features of neurological disorders in Alzheimer's disease and vascular dementia
- Authors: Levin O.S.1, Gavrilova SI1, Zhdaneeva LV1, Levin OS1, Gavrilova SI1, Zhdaneyeva LV1
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- Issue: Vol 17, No 2 (2011)
- Pages: 14-18
- Section: Articles
- URL: https://medjrf.com/0869-2106/article/view/37888
- DOI: https://doi.org/10.17816/rmj37888
- ID: 37888
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Abstract
Alzheimer's disease (AD) is the most common degenerative disease among the elderly, which mainly manifests as progressive dementia. In late-stage disease, a high proportion of patients also develop motor disorders, the syndromal characteristics and differential diagnostic value of which remain inadequately studied. The study was undertaken to evaluate motor disorders in patients with AD in its various stages versus those with vascular dementia (VD).
Ninety patients with AD and 30 with VD were examined. The groups were matched for age and dementia severity. Neurological disorders were detectable in 79 (87.7%) and 30 (100%) patients with AD and VD, respectively. The most common conditions included akinetic-rigid syndrome (18.9% vs 6.7%), hypokinesia without rigidity (27.8% vs 46.7%), postural and kinetic tremor (8.9% vs 3.3%), primary walking and postural resistance disorders (12.2% vs 26.7%), pseudobulbar syndrome (76.6% vs 100%), stereotypy (45.6% vs 30%), and pyramidal syndrome (12.2% vs 66.7%). Seizures occurred only in AD (6.7%). Thus, akinetic-rigid syndrome, tremor, stereotypy, and seizures were more common in AD than in VD whereas hypokinesia without rigidity, primary walking and postural resistance disorders, pyramidal and pseudobulbar syndromes were significantly more frequently encountered in VD. In AD, neurological disorders manifested later (in the severer dementia stage) than those did in cerebrovascular disease.
Ninety patients with AD and 30 with VD were examined. The groups were matched for age and dementia severity. Neurological disorders were detectable in 79 (87.7%) and 30 (100%) patients with AD and VD, respectively. The most common conditions included akinetic-rigid syndrome (18.9% vs 6.7%), hypokinesia without rigidity (27.8% vs 46.7%), postural and kinetic tremor (8.9% vs 3.3%), primary walking and postural resistance disorders (12.2% vs 26.7%), pseudobulbar syndrome (76.6% vs 100%), stereotypy (45.6% vs 30%), and pyramidal syndrome (12.2% vs 66.7%). Seizures occurred only in AD (6.7%). Thus, akinetic-rigid syndrome, tremor, stereotypy, and seizures were more common in AD than in VD whereas hypokinesia without rigidity, primary walking and postural resistance disorders, pyramidal and pseudobulbar syndromes were significantly more frequently encountered in VD. In AD, neurological disorders manifested later (in the severer dementia stage) than those did in cerebrovascular disease.
About the authors
Oleg Semenovich Levin
S I Gavrilova
L V Zhdaneeva
O S Levin
S I Gavrilova
L V Zhdaneyeva
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