Russian Medicine

Peer-review bimonthly academic medical journal. 

 

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The journal founded in 1937 is intended for physicians of all specialties, healthcare professionals, drug developers and regulators, researchers of scientific, medical and educational organizations. Being the central national place for medical data publications, the journal primarily covers the practical issues of diagnosis and treatment of diseases, as well as information on the most important and actual theoretical and practical aspects of health care and medical science.

Readers will find in this journal the most relevance and actual reviews, lectures and original study articles that have priority for Russian national healthcare system and deserve to be published.

Articles types

  • reviews
  • systematic reviews and metaanalyses
  • original research
  • clinical case reports and series
  • letters to the editor
  • short communications
  • clinial practice guidelines

 

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  • Bimonthly issues (6 times a year)
  • Continuoulsly publications online (Online First)
  • Hybrid Access (Open Access articles published with CC BY-NC-ND 4.0 License)
  • articles in English & Russian
  • Article submission charge

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  • Russian Science Citation Index (on WoS)
  • CrossRef
  • Google Scholar
  • Ulrich’s International Periodicals Directory
  • Dimensions

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Current Issue

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Vol 30, No 3 (2024)

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Original Research Articles

Medico-demographic and medico-social determinants of the birth rate of the population in the Chechen Republic
Shapovalova M.A., Ezhaev A.V., Yaroslavtsev A.S., Perepechkin A.N., Abramova D.A., Abdullaeva A.S., Saprykin G.A.
Abstract

BACKGROUND: Over the years, the birth rate in Russia has decreased due to a transformation in the family structure, a change in attitudes toward marriage and family, and economic and social reasons. The ratio of fertility and mortality determines the population reproduction regime, changing economic development and national security conditions. The analysis and assessment of the birth rate in the Chechen Republic is crucial because the results can be used to formulate a system of demographic policy measures considering national traditions of matrimonial behavior.

AIM: To develop recommendations for increasing the birth rate of the population in the Chechen Republic as a territory with strong traditions of the priority of family values.

MATERIALS AND METHODS: The study was conducted based on official statistics of the Chechen Republic for 2010–2021 and a sociological survey of mothers.

RESULTS: Medical and demographic processes in the territory of the Chechen Republic had a general unfavorable trend in the 12-year period from 2010 to 2021. The only positive aspect that can be considered is a threefold decrease in the birth rate in the same period among mothers aged >40 years, as older mothers carry a large burden of chronic pathology, causing a risk to the health of newborns.

CONCLUSION: Negative stable trends in age-specific decline in fertility in the reproductive period among women in the Chechen Republic indicated the unfavorable demographic situation in Russia, despite the priority of family values and stable traditions of large families. The reserves for improving the demographic situation in the region are hidden in the need for systematic information support for families to use their rights to state benefits aimed at protecting motherhood and childhood, monitoring and evaluating the effectiveness of these measures.

Russian Medicine. 2024;30(3):208-217
pages 208-217 views
Facial nerve neuropathy during the COVID-19 pandemic: clinical features, acupuncture treatment approaches
Andreeva G.O., Odinak M.M., Litvinenko E.V., Lobzin V.Y., Shishkina E.V.
Abstract

BACKGROUND: Facial nerve neuropathy (FNN) is a common mononeuropathy in the general stage of development of the peripheral nervous system. During the novel coronavirus disease (COVID-19) pandemic, the incidence of facial neuropathy increased from 1.3% in 2019 to 3.5% in 2020. Acute isolated neuropathy of the facial nerve may be the first and only manifestation of various infectious diseases, including COVID-19. Several experts showed that the mechanisms of facial neuropathy development after a coronavirus infection is associated with neuroinflammation.

Accepted therapeutic algorithms do not always lead to the expected results. Acupuncture potentially plays a key role in the treatment of this disease. In several cases, its superiority over drug treatment for FNN has been noted. No Russian studies on the treatment of post-COVID FNN were found.

AIM: This study aimed to study the clinical features of the course of FNN after COVID-19, develop reflexology approaches to treatment, and compare the course of FNN between patients with a history of coronavirus infection and those without a history of COVID-19 infection.

MATERIALS AND METHODS: The study group (after COVID-19) consisted of 16 patients with FNN (13 men, 3 women). The comparison group included 21 patients with FNN without a history of COVID-19 (15 men, 6 women). For a comprehensive patient assessment, clinical, neurological, and electroneuromyographic examination data were used.

RESULTS: The treatment results of 16 patients with FNN that developed up to 12 weeks after suffering from COVID-19 were analyzed. The onset of the disease was accompanied by an arterial hypertension episode, which was observed for the first time in two patients. Nerve fiber damage was mixed and severe (>52%). The dynamics of clinical and electrophysiological parameters in the study group (after COVID-19) were significantly slower compared to that of the group without a history of COVID.

CONCLUSION: FNN that develops after COVID-19 is characterized by severe nerve fibers damage and a long course. Reflexology is an effective and safe method as part of complex therapy.

Russian Medicine. 2024;30(3):218-227
pages 218-227 views
Scientific rationale for the indicators of biological urine monitoring in adolescents in Kazan City
Gizatullina D.Z., Akberov D.R., Gazieva T.I., Valeeva E.R., Stepanova N.V.
Abstract

BACKGROUND: Biomonitoring is crucial for assessing the level of pollution in a population, identifying risks and studying the impact of changes in technology. Knowledge of the reference values of trace elements in biological material is critical in comparing exposed with non-exposed groups and accurate. The control values of trace elements are crucial for ensuring public health and occupational safety.

AIM: To study and analyze concentrations of priority chemical pollutants in the urine of adolescents aged 14–17 years in three zones in Kazan City and determine reference values for this age group.

MATERIALS AND METHODS: The concentration of elements in urine of 276 adolescents aged 14–17 years was measured by inductively coupled plasma mass spectrometry.

RESULTS: The upper 95 percentiles and their confidence intervals (RV95) were determined, which established the upper limit of the current background exposure to adolescents for 12 biomarkers, interpreted as “conditional” reference values for this age group. The following reference values for adolescents in Kazan City were obtained: Al, 12.80 µg/L; Cr, 1.02 µg/L; Mn, 3.53 µg/L; Hg, 0.65 µg/L; Cu, 110.91 µg/L, and Ni, 8.72 µg/L. In adolescents, the highest level of exceedance over background values was observed in zones 1 and 2 (Kirovsky and Privolzhsky Districts): Al exceeded by 1.4 times, Cr by 1.3 times in zone 1 (Kirovsky District), Mn by 1.5 times, Hg by 1.3 times, and Cu by 1.14 times in zone 2 (Privolzhsky district).The results are of interest for further analysis and identification of interrelations in the territory of the Republic of Tatarstan, Russia, where exposure levels may vary between regions or separate subgroups living in the same territory.

CONCLUSION: Research in the field of biomonitoring in Kazan established the levels of exposure to toxic elements among the studied population and provided means for comparing exposure for further research by population groups by age, sex, and ethnicity. Moreover, biomonitoring results can be used to determine research priorities, measure exposure trends over time, and verify effectiveness of individual measures to combat pollution and other measures in the field of the environment and public health. The study presents modern technologies for assessing exposure to chemical pollutants using human biomonitoring methods and demonstrates its advantages.

Russian Medicine. 2024;30(3):228-237
pages 228-237 views
Comprehensive assessment of the accuracy of heart rate determination with the personal wearable device
Tikhomirov L.I., Vasil’ev L.M., Tachkin D.V., Khovaeva Y.B., Prokopenko T.I., Moiseenko N.P., Ermachkova L.V., Kirillov A.O.
Abstract

BACKGROUND: Increased resting heart rate (HR) is an independent risk factor for overall mortality, sudden cardiac death, and death from cardiovascular diseases (CVD) and a worsening factor for CVD patients’ prognosis. Moreover, HR is easy to measure and monitor independently using various devices. The accuracy of personal wearable devices used in assessing HR should be investigated.

AIM: To evaluate the accuracy of HR determination with the personal wearable device (PWD).

MATERIALS AND METHODS: An open, observational, single-center study was performed. Participants underwent physical examination, electrocardiography, HR recording using PWD, and electrocardiography Holter monitoring (HMECG). For each participant, the study duration was 14 days. The reliability of HR measured in everyday life was assessed using the PWD in comparison with HMECG as the “gold” standard. For statistical analysis, Microsoft Excel 2016 and STATISTICA 10.0 software were used. To assess the reliability of HR measured in everyday life using PWD in relation to HMECG, the hypothesis of the equality of average HR values measured by both methods was tested, a correlation analysis of time series of HR values was conducted, and Bland–Altman plots were used to visualize differences in HR values.

RESULTS: The study involved 45 healthy individuals (22 men, 49.24±6.47 years). HR data were obtained over a 24-hour period, including the subjects' routine working day. The results demonstrated good convergence between data on HR using PWD and HMECG. The relative error in determining the HR of PWD did not exceed 3.2%. The smallest relative error was recorded at night and early morning hours (0.3÷1.1%). During the daytime it was slightly higher — from 2.0 to 3.2%. A significantly high positive correlation was obtained between HR recorded using both devices, both at night (MCorrP from 0.75 to 0.85; p <0.001) and during daytime (MCorrP from 0.77 to 0.85; p <0.001).

CONCLUSION: The accuracy comparison of 24-hour HR measurements by PWD showed that they were mostly within the acceptable error range (less than 3.2%). Future studies should include HR PWD assessment in patients with various diseases.

Russian Medicine. 2024;30(3):238-248
pages 238-248 views

Reviews

Diacylglycerides as nutrition components or precursors of carcinogens: a critical view on an ambular question
Budnevsky A.V., Ovsyannikov E.S., Popov V.I., Drobysheva E.S., Feigelman S.N.
Abstract

Obesity is considered as a noninfectious epidemic worldwide. Metabolic disorders associated with the accumulation of adipose tissue lead to obesity-associated diabetes mellitus and cardiovascular diseases. Diet is a component of treatment of diseases associated with obesity. The most commonly used diets are caloric restriction by reducing fat in the diet. Over the years, there have been several attempts to use diacylglycerol (DAG) as components of dietary oils owing to its ability to suppress the accumulation of visceral fat and reduce postprandial levels of triacylglycerol and cholesterol and glucose in the blood serum. However, in 2009, it was found that when oil was processed at high temperatures during physical refining, DAG-enriched oil had the highest levels of potentially harmful glycidyl esters compared to conventional refined fats and oils. The study of the negative effects of glycidyl esters has prompted the food industry, which has traditionally used oil, to focus on strategies in preventing or mitigating these effects by changing the refining process or modifying deodorization equipment to reduce or eliminate process contaminants.

Russian Medicine. 2024;30(3):249-259
pages 249-259 views
Right heart status in patients with COVID-19: a literature review
Karasev A.A., Poteshkina N.G., Lysenko M.A., Krylova N.S., Svanadze A.M., Maslova M.Y., Beloglazova I.P.
Abstract

The COVID-19 pandemic has placed unprecedented strain on healthcare worldwide. Considering that the main pathophysiological processes causing the severe and extremely severe course of the disease are COVID-19-associated pneumonia and hypercoagulation, the hemodynamics of pulmonary circulation and the right heart was of particular concern. Echocardiography has become the main method for assessing the condition of the right heart in COVID-19 patients, owing to its availability and speed of the investigation. However, echocardiographic assessment of the right heart is challenging, and data in the available literature are conflicting.

The functioning of the right parts of the heart regarding normality and in conditions of COVID-19 infection is shown. The results of studies aimed at assessing the structural, hemodynamic, and functional parameters of the right heart during the acute course of the disease and in the long-term period — from a month to a year — were studied. Currently, there is no consensus on the effect of COVID-19 on the condition of the right side of the heart in the long term and, accordingly, further monitoring of patients who have had COVID-19, especially severe and extremely severe cases, is required.

Russian Medicine. 2024;30(3):260-271
pages 260-271 views
Bile reflux after laparoscopic mini/one anastomosis gastric bypass: the problem and prevention
Vinnik Y.S., Chaykin A.A., Chaykin D.A., Teplyakova O.V., Yureva M.Y., Boyakova N.V., Vlasenko D.S., Bakhshyan V.A.
Abstract

Currently, laparoscopic mini-gastric bypass (LMGB) is a common bariatric surgical operation. One of the reasons for reoperations after LMGB is pathological bile reflux, which, in addition to a noticeable decrease in the quality of life of patients, poses a potential threat to the neoplastic processes in the stomach and esophagus.

This study aimed to systematize and analyze modern literature information on terminology, diagnosis and frequency of detection, pathophysiological significance, and methods of preventing bile reflux post-LMGB. Russian and English full-text studies on bile reflux after LMGB in the bibliographic databases of the Russian Science Citation Index, PubMed, Google Scholar, and ScienceDirect were analyzed.

The frequency of diagnosing bile reflux after LMGB varies from 2.0 to 57.9%, depending on the instrumental diagnostic methods used: flexible endoscopy, 24-hour pH impedance measurements, spectrophotometry of bilirubin in refluxate, and hepatobiliary scintigraphy. The pathogenetic effect of the contents of the small intestine on the mucous membrane of the stomach and esophagus after LMGB is noted because of the direct cytotoxic and receptor-mediated effects of bile acids. The safety of the main stages of LMGB (creation of a gastric pouch and formation of a single anastomosis) is currently being reviewed from the standpoint of minimizing the risk of developing bile reflux. Furthermore, novel techniques have been proposed to reduce the likelihood of intestinal contents entering the stomach and esophagus; however, their effectiveness remains controversial.

Russian Medicine. 2024;30(3):272-284
pages 272-284 views
Comparison of the efficacy of paracetamol and ibuprofen for fever in children under 5 years of age
Abramov V.V., Maximov M.L., Romanov B.K., Shikaleva A.A.
Abstract

Fever accounts for a significant proportion of pediatric emergency consultations, with up to 40% of children under the age of five see a doctor for this condition. Fever is usually the result of acute respiratory viral infection, is short-lived and resolves on its own. However, in the hyperergic variant or with depletion of compensatory mechanisms, fever can be the cause of the development of pathological conditions. Therefore, timely and effective control of fever has always been a subject of interest to parents and pediatricians.

Current guidelines define fever above 38.5 °C as a condition in which the use of antipyretics is indicated. Paracetamol (acetaminophen) and ibuprofen are the most widely prescribed and available over-the-counter antipyretics in children. Despite the widespread use of these drugs, recommendations for the treatment of young children remain varied, leading to irrational use of antipyretics. Therefore, the aim of this review is to analyze existing clinical trials comparing paracetamol and ibuprofen to develop guidelines for pediatricians on the management of febrile pediatric patients.

Russian Medicine. 2024;30(3):285-294
pages 285-294 views
Use of humic acids in the treatment of genitourinary diseases
Benderskii N.S., Bolurova L.A., Yusupova N.R., Berezovskaya D.V., Popova E.E., Yakovlev G.G., Gaivorontsev M.V., Khodosenko Y.V., Dzhemoldinova I.E.
Abstract

Currently, diseases of the urogenital system has acquired medical and social importance. This is primarily due to the significant prevalence of this group of diseases in the structure of general morbidity, disability, and mortality and their frequent recurrence and effect on the somatic and emotional state of the patient. In addition to socio-demographic problems, urogenital disorders have significant economic consequences. The total annual costs of treating uronephrological diseases, including accompanying therapy, are estimated at 40 billion US dollars. However, according to expert forecasts, by 2030, the prevalence of this group of diseases is expected to increase by 25%, as well as direct costs of disease treatment and indirect costs associated with partial or total disability due to disease development and premature death.

Thus, searching for and developing new drugs for the treatment of diseases of the urogenital organs are crucial. Chemical compounds, potentially significant in this aspect, can be obtained by organic synthesis and isolated from natural sources. Thus, exploring the potential of natural compounds that have high biological activity and favorable safety profile is a significant reason to realize and address this issue. An interesting but understudied groups of natural compounds of plant origin are humic substances. Recent preclinical studies have shown that they are able to exert antitumor, nephroprotective, and diuretic effects and exhibit antibacterial and antifungal properties.

This review aimed to summarize and systematize currently available information on the known pharmacological effects and possible mechanisms of action of humic acids and the prospects for their use in the treatment and prevention of genitourinary diseases.

Russian Medicine. 2024;30(3):295-308
pages 295-308 views

Case reports

A clinical case of isolated non-compact left ventricular myocardium in a 29-year-old patient
Alieva A.M., Kovtyukh I.V., Teplova N.V., Voronkova K.V., Reznik E.V., Baykova I.E., Totolyan G.G., Timofeev V.T., Kotikova I.A., Nikitin I.G.
Abstract

BACKGROUND: Non-compact left ventricular myocardium is a rare heterogeneous pathology, which in the two-layer structure of the myocardium. There is no generally accepted definition of this form of pathology for both echocardiography and cardiac magnetic resonance imaging. Non-compact left ventricular myocardium can occur at any age and is often asymptomatic. Treatment of non-compact left ventricular myocardium is nonspecific and symptomatic.

DESCRIPTION: This study describes a clinical case of a young patient who was diagnosed with non-compact left ventricular myocardium. The disease debuted in the form of cardiac arrhythmia. Holter monitoring showed frequent ventricular extrasystole and atrioventricular block of the first and second degrees. Moreover, echocardiography revealed a decrease in global contractile function of the left ventricle. The diagnosis was made after magnetic resonance imaging of the heart, which revealed the presence of non-compact myocardium of the anterior, lateral, and inferior walls of the left ventricle in the apical and middle segments. Sustained rhythm disturbances were not induced in electrophysiological research by rapid and programmed stimulation. The patient was prescribed antiarrhythmic therapy, followed by echocardiography Holter monitoring. In the future, the patient needs regular monitoring by a cardiologist.

CONCLUSION: Non-compact left ventricular myocardium should be diagnosed at an early stage, so that life expectancy can be increased owing to timely treatment of heart failure and the use of oral anticoagulants, antiarrhythmic drugs, cardiac resynchronization therapy, cardioverter-defibrillator implantation, and heart transplantation when other treatment options are ineffective.

Russian Medicine. 2024;30(3):309-318
pages 309-318 views


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