Medical Journal of the Russian Federation

Peer-review bimonthly academic medical journal. 


The journal founded in 1937 is intended for physicians of all specialties, healthcare professionals, drug developers and regulators, researchers of scientific, medical and educational organizations. Being the central national place for medical data publications, the journal primarily covers the practical issues of diagnosis and treatment of diseases, as well as information on the most important and actual theoretical and practical aspects of health care and medical science.

Readers will find in this journal the most relevance and actual reviews, lectures and original study articles that have priority for Russian national healthcare system and deserve to be published.




Articles types

  • reviews
  • systematic reviews and metaanalyses
  • original research
  • clinical case reports and series
  • letters to the editor
  • short communications
  • clinial practice guidelines

APC, Publication & Distribution

  • Bimonthly issues (6 times a year)
  • Continuoulsly publications online (Online First)
  • Hybrid Access (Open Access articles published with CC BY-NC-ND 4.0 License)
  • articles in English & Russian
  • Article submission charge


  • Russian Science Citation Index (on WoS)
  • CrossRef
  • Google Scholar
  • Ulrich’s International Periodicals Directory
  • WorldCat


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Vol 29, No 4 (2023)

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Original Research Articles

Early detection of the risk of cognitive disorders
Mashkova I.Y., Dmitrieva E.V., Krikova A.V., Aleschkina G.A., Bardenshteyn L.M.

BACKGROUND: Cognitive disorders are a relevant problem in an aging population. Research shows a wide range of data on the prevalence of cognitive disorders in the general population. Thus, more studies on the prevalence of cognitive disorders and assessment of the risks of their development are necessary, which will determine the burden on the regional healthcare system.

AIM: To examine the prevalence of cognitive impairment in an outpatient multidisciplinary clinic setting and determine the risk ratios for cognitive deficits in different age groups.

MATERIALS AND METHODS: The Montreal Cognitive Assessment Scale was used in the screening of people aged 45–90 years.

RESULTS: Cognitive dysfunction was noted in 20.0% of patients in the group aged 45–59 years, 33.1% in the group aged 60–74 years, and 79.6% in the group aged 75–90 years. The average results on the assessment of cognitive functions of persons aged 45–59 (27.1±0.3) and 60–74 (26.2±0.2) years corresponded to the norm, and the value in persons aged 75–90 (23.6±0.3) years was below the norm. In groups aged 60–74 and 75–90 years, the prevalence of cognitive dysfunction was comparable between men and women. Cognitive impairments in men aged 45–59 years were recorded 2.5 times more often than that in women. The risk of cognitive disorders in the second group (aged 60–74 years) relative to that in the first group (aged 45–59 years) is insignificant (relative risk [RR], 1.21). In the third group (aged 75–90 years), the probability of cognitive disorders is significantly higher than that in the second group (RR=2.40) and nearly five times higher than that in the first group (RR=4.86).

CONCLUSION: Sex- and age-stratified screening indicators for assessing cognitive functions and the RRs of developing cognitive disorders in older age groups make it possible to plan for diagnostic, therapeutic, and preventive measures in mental health.

Medical Journal of the Russian Federation. 2023;29(4):255-264
pages 255-264 views
Pharmacoepidemiological analysis of the consumption of antibacterial drugs for the treatment of patients with nosocomial infections associated with previous hospitalization in multidisciplinary hospitals in the Tomsk region
Perfileva D.Y., Miroshnichenko A.G., Perfilev V.Y., Kulikov E.S., Boykov V.A., Nesterovich S.V., Zima A.P.

BACKGROUND: Healthcare-associated infections (HAIs) are one of the common complications associated with patients’ stay in a medical organization. An urgent practical problem is the choice of antibiotic therapy for the treatment of patients with nosocomial infections because these infections are caused by antibiotic-resistant strains. HAIs associated with previous hospitalization (HAPH) manifest in patients after discharge from the hospital, and their risk of isolating resistant strains often remains unrecognized by specialists. Thus, more studies are required to examine the structure of HAPH pathogens and patterns of consumption of antibacterial drugs for the treatment of HAPH to further determine antibiotic therapy in these patients.

AIMS: To analyze the use of antibiotic therapy for the treatment of HAPH with known etiological agents and the level of antibiotic resistance.

MATERIALS AND METHODS: The study analyzed the results of a multicenter descriptive retrospective study based on the Clinics Siberian State Medical University and the State Clinical Hospital No. B.I. Alperovich (Tomsk). A total of 108 HAPH cases were examined according to the medical records of inpatients (Form 003/y). For pharmacoepidemiological analysis, the anatomical therapeutic chemical/defined daily dose (DDD) methodology was used, and antibiotic intake was assessed using the number of established daily doses. The etiological structure of HSV microorganisms was evaluated using the AMRcloud online platform. Quantitative and qualitative indicators were presented as shares (%) and absolute numbers.

RESULTS: In total, 116 isolates from patients with HAPH were assessed. Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli were the dominant pathogens causing HAPH in the overall distribution of pathogens. For the treatment of these patients, a wide range of drugs was used, including 13 groups of antibiotics. In most cases, the parenteral route of drug administration was used: intravenous route, 56.0%; intramuscular, 28.0%; and oral, 16.0%. The DDD analysis showed that antibiotic intake for the treatment of patients with HAPH was 137.8 NDDD/100 bed-days; surgical infection, 48.2 NDDD/100 bed-days (35.0%); and pneumonia, 89.6 NDDD/100 bed-days (65.0%). Cephalosporins were the most commonly used group of antibiotics for both surgical infection and pneumonia, mainly third-generation cephalosporins.

CONCLUSION: Etiological agents of HAPH are phenotypically similar to nosocomial strains. Among antibacterial drugs, cephalosporins and fluoroquinolones were mainly consumed, and HAPH isolates had unfavorable resistance profiles to these drugs.

Medical Journal of the Russian Federation. 2023;29(4):265-276
pages 265-276 views
Effect of post-COVID syndrome on the quality of life of patients with allergic rhinitis and eosinophilic phenotype of chronic polyposis rhinosinusitis
Korkmazov M.Y., Lengina M.A., Korkmazov A.M., Kravchenko A.Y.

BACKGROUND. An urgent issue of modern medicine is the study of the quality of life of people with post-COVID syndrome. Particular emphasis is placed on patients with various forms of allergic rhinitis associated with comorbid conditions such as polyposis rhinosinusitis. These diseases are still common and tend to increase. In this context, the study of the effect of conservative methods of treatment of allergic rhinitis and polyposis rhinosinus on the quality of life of patients will improve the effectiveness of the therapy.

 AIMS: To assess the impact of post-COVID syndrome on the quality of life of patients with various forms of allergic rhinitis and eosinophilic phenotype of chronic polyposis rhinosinusitis and to determine the effectiveness of conservative therapy.

MATERIALS AND METHODS: In the period from May to December 2021, a study was conducted on the quality of life in the treatment of 62 patients against the background of post-covid syndrome, of which 32 patients suffered from polypous rhinosinusitis and 30 patients with allergic rhinitis. The disease of coronavirus infection was registered 2-3 months before the visit to the otorhinolaryngologist. The comparison groups included 65 people, including 33 patients with polypous rhinosinusitis and 32 with various forms of allergic rhinitis. The Russian version of the standard SF-36 questionnaire was used to collect anamnesis. A visual analogue scale was used to measure the intensity of rhinological symptoms. All patients were examined three times: before treatment, 1 and 3 months after the course of therapy.

RESULTS: A comparative analysis of the quality of life indicators of patients with various forms of allergic rhinitis and polyposis rhinosinusitis showed a direct dependence on the condition of patients after a coronavirus infection. 

CONCLUSIONS: The use of the assessment of quality of life indicators at the stages of treatment of patients with various forms of allergic rhinitis and polypous rhinosinusitis against the background of post-covid syndrome makes it possible to determine the effectiveness of conservative therapy and timely adjust the treatment.

Medical Journal of the Russian Federation. 2023;29(4):277-290
pages 277-290 views
Clinical and immunological parameters of dental status in children with type 1 diabetes mellitus
Kiselnikova L.P., Gutnik A.A., Ostrovskaya I.G., Malanchuk I.I., Laptev D.N.

BACKGROUND: Destructive processes in the pancreas in type 1 diabetes mellitus alter oral homeostasis. The first signs of a change in dental health in type 1 diabetes mellitus are pastosity of the oral mucosa and hyposalivation, which causes dental plaque formation. Many researchers note the high prevalence of periodontal disease in patients with type 1 diabetes mellitus.

AIM: To examine the dental status, cytokine profile, and specific factors of oral immunological protection in children with type 1 diabetes mellitus.

MATERIALS AND METHODS: Two groups of children aged 6–17 years were examined. The main group (n=53) included patients with type 1 diabetes mellitus, whereas the comparison group (n=30) included children without somatic pathologies. The study analyzed the results of a clinical examination of patients, including an assessment of the intensity of caries, oral hygiene, and periodontal status, and results of an immunological examination of the oral fluid, including the level of cytokines (interleukin (IL)-1β, tumor necrosis factor-α, IL-4, and IL-10) and immunoglobulins (IgA, IgG, and IgM).

RESULTS: Both groups had satisfactory levels of oral hygiene, and the extent of plaque formation on the proximal surfaces of the teeth was unacceptable. The prevalence of chronic catarrhal gingivitis was higher in the main group. An immunological study showed that both groups had pro-inflammatory cytokine imbalance in the oral fluid, and the levels of these cytokines are higher in the main group. The levels of immunoglobulins in the oral fluid were also different: the levels of IgA and IgM in the saliva of the main group were 1.1 and 1.2 times higher, and the IgG level was 1.25 times lower.

CONCLUSION: The high prevalence of periodontal disease in children with type 1 diabetes mellitus was associated with poor oral hygiene and carbohydrate metabolism. Patients with type 1 diabetes mellitus showed a pronounced imbalance of oral immunological protection factors. With worsening compensation of carbohydrate metabolism, immunological changes in the oral cavity became more pronounced.

Medical Journal of the Russian Federation. 2023;29(4):291-299
pages 291-299 views
Substantiation of the method of local deep hypothermia for the relief of synovitis of the knee joint in patients with osteoarthritis
Tereshenkov V.P., Shevelev O.A., Zagorodniy N.V., Khodorovich N.A., Akhpashev A.A.

BACKGROUND: In patients with osteoarthritis, the long course of synovitis changes the nature of the inflammatory process, it becomes more resistant and resistant to a number of therapeutic techniques. In the arsenal of a practicing doctor, there are no reliable and affordable therapeutic methods that reliably provide relief of synovitis in the knee joint and objectively monitor the effectiveness of the therapy. Among the numerous methods of application in the treatment of diseases and injuries of the musculoskeletal system, low-molecular technologies with anti-inflammatory and analgesic effects are distinguished. One of these methods is local deep hypothermia.

AIM: To substantiate the use of different low-temperature modes of local deep hypothermia in patients with knee osteoarthritis aggravated by synovitis, to study clinical efficacy and safety.

MATERIALS AND METHODS: The study included 90 patients with osteoarthritis of the knee joints, burdened with synovitis. To determine the therapeutic parameters of local deep hypothermia, all patients were divided into three groups of 30 people. The effectiveness of the performed local deep hypothermia was assessed by the dynamics of the algofunctional Leken index, the intensity of joint pain on a 100-point Visual Analogue Scale (VAS) in millimeters and a decrease in the need for nonsteroidal anti-inflammatory drugs (NSAIDs).

RESULTS: Technical and clinical parameters have been developed for carrying out the local deep hypothermia technique: area, cooling depth, rate of heat removal from the joint, duration of reproduction and number of procedures. Against the background of the performed local deep hypothermia, patients in three groups showed significant positive dynamics on the VAS and algofunctional Leken index, and in all three groups the difference between the initial and final values of these parameters was statistically significant (p <0.001). The use of local deep hypothermia allowed a significant part of patients to refuse to take NSAIDs, or to reduce the need to 50 mg and take episodically according to need. In our study, we did not record a recurrence of synovitis in all three groups during the first 3 months, which was 100%. After 12 months, the duration of remission in group I was 10.0%, in group II patients — 73.3% and in group III patients — 86.6%.

CONCLUSION: Local deep hypothermia improves the effectiveness of synovitis treatment and can be recommended as an independent method for the treatment of patients with osteoarthritis of the knee aggravated by synovitis. The recommended local deep hypothermia exposure is 90 min, which allows for the longest period of remission of synovitis in the knee joint.

Medical Journal of the Russian Federation. 2023;29(4):300-310
pages 300-310 views


Current insights into the role of miRNA-125 in cardiovascular disease: potential biological markers and therapeutic targets
Alieva A.M., Teplova N.V., Reznik E.V., Baikova I.E., Akhmedova M.F., Butenko A.V., Balagova B.Z., Modestova A.V., Kotikova I.A., Valiev R.K., Nikitin I.G.

Recently, miRNAs are being used as diagnostic markers for various pathological conditions. This review analyzed the main studies devoted to the role of miRNA-125 in the development of cardiovascular diseases. Members of the miRNA-125 family are involved in cell differentiation, proliferation, and apoptosis by targeting mRNAs associated with these cellular processes. This miRNA can enhance or inhibit pathological processes such as oncogenesis, muscle abnormalities, neurological disorders, and others. Members of the miRNA-125 family also influence the development and function of immune cells and are involved in immunological defense. Research shows that the miRNA-125 family is associated with cardiac development. They also play an important role in pathophysiological conditions of the cardiovascular system. However, the same miRNA-125 family members play different roles in different pathological processes. For example, miRNA-125b overexpression in cardiomyocytes can inhibit their apoptosis and inflammatory response. However, miRNA-125b is also a regulator of cardiac fibrosis; its overexpression in cardiac fibroblasts can enhance their proliferation. Therefore, in pathological conditions, miRNA-125b excess aggravates myocardial fibrosis and remodeling, destroys the original morphological structure of the heart, disrupts neovascularization processes, and aggravates apoptosis of cardiomyocytes in the damaged area. Thus, to avoid adverse reactions, the optimal dose and timing of therapeutic intervention using members of the miRNA-125 family, their inhibitors, and mimetics must be carefully determined. An expanded and accurate understanding of miRNA-125 functions in gene regulatory networks associated with cardiovascular pathology will enable the development of novel and innovative therapeutic strategies.

Medical Journal of the Russian Federation. 2023;29(4):311-324
pages 311-324 views
Biomarkers and prognostic models for severe COVID-19 in comparison with other etiologies of sepsis
Sсherbak S.G., Sarana A.M., Vologzhanin D.A., Golota A.S., Kamilova T.A., Makarenko S.V.

Severe COVID-19 shares pathophysiological, immunological, metabolic, and clinical features with classic bacterial sepsis. Patients with severe COVID-19 have sepsis-like manifestations, such as acute respiratory distress syndrome and multiple organ failure. However, research indicates that COVID-19 leads to acute respiratory distress syndrome and that septic syndrome is more fatal than septic syndrome of other etiologies. SARS-CoV-2 initially infects the lungs; however, in COVID-19-associated sepsis, the majority of deaths are caused by the subsequent involvement of multiple organs. Many patients who died because of COVID-19 died from sepsis, a life-threatening dysfunctional response to infection that is accompanied by respiratory and multiple organ failure.

Overlapping molecular characteristics are found in patients with severe COVID-19 and sepsis from all causes. Endotypes that reflect different etiologies of sepsis have been identified in patients with severe COVID-19. Whole-blood proteomics and transcriptomics are useful in identifying the pathogenetic mechanisms and multimolecular signatures of COVID-associated sepsis and other sepsis, which allow for the development of more specific criteria for early diagnosis, patient classification, and therapeutic choices.

The detection of sepsis endotypes in patients with COVID-19 implies that sepsis endotypes may be useful for clinical risk stratification in COVID-associated sepsis and the potential opportunity to treat these patients with targeted immunomodulatory therapies that can correct endotype-specific dysfunctional immune processes.

Medical Journal of the Russian Federation. 2023;29(4):325-348
pages 325-348 views

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